LOCALLY ADVANCED BREAST CANCER
Clinical trials for LOCALLY ADVANCED BREAST CANCER explained in plain language.
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New drug combo shows promise against tough breast cancer
Disease control OngoingThis study tests whether adding the experimental drug onvansertib to standard chemotherapy (paclitaxel) is safe and effective for people with triple-negative breast cancer that has spread to other parts of the body. About 50 adults with advanced disease are participating. The goa…
Matched conditions: LOCALLY ADVANCED BREAST CANCER
Phase: PHASE1, PHASE2 • Sponsor: Antonio Giordano, MD • Aim: Disease control
Last updated May 17, 2026 02:06 UTC
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Radiation before chemo: a new immune booster for aggressive breast cancer?
Disease control OngoingThis study tests whether giving a small dose of targeted radiation to the tumor before standard chemotherapy can prime the immune system to better attack high-risk breast cancer. About 40 adults with locally advanced breast cancer will receive three radiation treatments, then pro…
Matched conditions: LOCALLY ADVANCED BREAST CANCER
Phase: NA • Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's • Aim: Disease control
Last updated May 17, 2026 02:00 UTC
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New drug RPH-051 takes on perjeta in battle against advanced breast cancer
Disease control OngoingThis study tests whether a new drug called RPH-051 works as well as the approved drug Perjeta when both are given with standard chemotherapy for HER2-positive breast cancer that has spread or cannot be removed by surgery. About 246 participants will receive either RPH-051 or Perj…
Matched conditions: LOCALLY ADVANCED BREAST CANCER
Phase: PHASE3 • Sponsor: R-Pharm • Aim: Disease control
Last updated May 13, 2026 16:00 UTC
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New combo therapy shows promise against aggressive breast cancer
Disease control OngoingThis study tests a new drug called BNT327, given with chemotherapy, for people with advanced triple-negative breast cancer. The goal is to see if the combination can shrink tumors and control the disease. About 83 adults will take part, and researchers will monitor side effects a…
Matched conditions: LOCALLY ADVANCED BREAST CANCER
Phase: PHASE2 • Sponsor: BioNTech SE • Aim: Disease control
Last updated Apr 23, 2026 12:44 UTC
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Can a simple biopsy spot hidden cancer after chemo?
Knowledge-focused OngoingThis study looks at how well sentinel lymph node biopsy finds leftover cancer cells after chemotherapy in women with locally advanced breast cancer. About 162 women who had chemotherapy and whose lymph nodes seemed cancer-free will get this biopsy. The goal is to see how often th…
Matched conditions: LOCALLY ADVANCED BREAST CANCER
Phase: NA • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Knowledge-focused
Last updated May 11, 2026 20:38 UTC