New hope for hard-to-treat breast cancer: experimental combo shows promise

NCT ID NCT06449222

Ongoing Disease control Sponsor: BioNTech SE Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 01, 2026 · Updated 2 times

Summary

This study tests a new drug called BNT327, given with chemotherapy, for people with advanced triple-negative breast cancer that has spread. The goal is to see if the combination is safe and shrinks tumors. About 83 adults will take part, and the study is currently active but not recruiting new participants.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

breast cancer triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALLY ADVANCED BREAST CANCER METASTATIC TRIPLE NEGATIVE BREAST CANCERS TRIPLE NEGATIVE BREAST CANCER

Contacts and locations

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Locations

Baskent Universitesi Tip Fakultesi Adana Hastanesi

Adana, 01120, Turkey (Türkiye)
Beverly Hills Cancer Center

Beverly Hills, California, 90211, United States
Bezmialem Vakif Universitesi Tip Fakultesi Hastanesi

Istanbul, 34093, Turkey (Türkiye)
Bon Secours St. Francis Medical Center

Midlothian, Virginia, 23114, United States
Carle Foundation Hospital d/b/a Carle Cancer Center

Urbana, Illinois, 61801, United States
Edinburgh Cancer Centre-Western General Hospital

Edinburgh, EH4 2XU, United Kingdom
Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi

Istanbul, 34722, Turkey (Türkiye)
Hacettepe Universitesi Kanser Enstitusu

Ankara, 06100, Turkey (Türkiye)
HealthPartners Regions Specialty Clinics

Saint Louis Park, Minnesota, 55426, United States
Hull and East Yorkshire Hospitals NHS Trust - Castle Hill Hospital

Cottingham, HU16 5JQ, United Kingdom
Koc Universitesi Hastanesi (Koc University Hospital)

Istanbul, 34010, Turkey (Türkiye)
Medical Park Seyhan Hospital

Adana, 01230, Turkey (Türkiye)
Memorial Ankara Hospital

Ankara, 06520, Turkey (Türkiye)
Peninsula Oncology Centre

Frankston, 3199, Australia
Peter MacCallum Cancer Centre

Melbourne, 3050, Australia
Rocky Mountain Cancer Centers (RMCC)

Denver, Colorado, 80220, United States
Rutgers Cancer Institute of NJ (Rutgers, The State University of New Jersey)

New Brunswick, New Jersey, 08901, United States
SCRI Oncology Partners

Nashville, Tennessee, 37203, United States
Saint John's Health Center - John Wayne Cancer Institute (JWCI)

Santa Monica, California, 90404-2312, United States
Sakarya University - Faculty of Medicine

Adapazarı, 54290, Turkey (Türkiye)
Sarah Cannon Research Institute

London, W1G 6AD, United Kingdom
Sbu Dr.A.Y. Ankara Onkoloji SUAM

Ankara, 06100, Turkey (Türkiye)
St Bartholomew's Hospital - Barts Health NHS Trust

London, EC1A 7BE, United Kingdom
St James's University Hospital - Leeds Teaching Hospitals NHS Trust

Leeds, LS9 7TF, United Kingdom
Stanford University School of Medicine - Stanford Cancer Institute (SCI) - Stanford Women's Cancer Center

Palo Alto, California, 94304-2201, United States
Stony Brook University Hospital

Stony Brook, New York, 11794, United States
The West Clinic, P.C. d/b/a West Cancer Center

Germantown, Tennessee, 38138, United States
University College London Hospitals NHS Foundation Trust

London, W1T 7HA, United Kingdom
Valkyrie Clinical Trials

Los Angeles, California, 90067, United States
Yale University - Yale Cancer Center

New Haven, Connecticut, 06520, United States
Yeditepe University Hospital

Istanbul, 34755, Turkey (Türkiye)