Radiation before chemo: a new strategy to fight High-Risk breast cancer?
NCT ID NCT03978663
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This trial is testing whether giving a small dose of targeted radiation to a part of the breast tumor before standard chemotherapy can help the immune system fight the cancer more effectively. The study includes 40 people with high-risk or locally advanced breast cancer. After radiation, participants receive standard chemotherapy and surgery, and researchers will check if the tumor disappears completely.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
stereotactic radiation therapy
What this could lead to
If it works, this could point toward a more effective treatment approach for high-risk breast cancer by using radiation to prime the immune system before chemotherapy.
What could go wrong
This is a small early-phase trial with only 40 participants, so results may not apply to all patients. The added radiation could cause side effects, and the benefit over standard care is not yet proven.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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London Regional Cancer Program
London, Ontario, Canada