Radiation before chemo: a new strategy to fight High-Risk breast cancer?
NCT ID NCT03978663
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This trial is testing whether giving a small dose of targeted radiation to a part of the breast tumor before standard chemotherapy can help the immune system fight the cancer more effectively. The study includes 40 people with high-risk or locally advanced breast cancer. After radiation, participants receive standard chemotherapy and surgery, and researchers will check if the tumor disappears completely.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- stereotactic radiation therapy
- What this could lead to
- If it works, this could point toward a more effective treatment approach for high-risk breast cancer by using radiation to prime the immune system before chemotherapy.
- What could go wrong
- This is a small early-phase trial with only 40 participants, so results may not apply to all patients. The added radiation could cause side effects, and the benefit over standard care is not yet proven.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
London Regional Cancer Program
London, Ontario, Canada
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Other studies related to the condition(s) this trial covers.
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