London Health Sciences Centre Research Institute Or Lawson Research Institute Of St. Joseph's

This trial is testing if using a very precise, high-dose form of radiation on every visible tumor can help people with cancer that has spread to many places in the body. It will compare this aggressive radiation approach to standard care to see if it helps patients live longer, k…

This study is testing if giving the blood thinner heparin during a common heart test prevents a complication where the wrist artery used for access gets blocked. About 1,623 patients having a planned heart catheterization through the wrist will be randomly assigned to receive no …

This study is testing a new treatment sequence for high-risk breast cancer. It aims to see if giving a short, targeted radiation treatment along with an immune-boosting drug directly into the tumor can better prepare the body's immune system before starting standard chemotherapy.…

This study is testing a new digital app called VIRTUES, designed to help people manage various heart conditions from home. It will enroll 2000 participants across Canada to try seven core modules covering areas like blood pressure, cholesterol, and post-heart attack care. The mai…

This study is testing whether high-intensity exercise performed during kidney dialysis treatments can better protect the heart from damage. It will involve 15 patients on regular dialysis. Researchers will compare different exercise intensities to see which best prevents the temp…

This study is testing whether a fecal microbiome transplant (FMT) can help people with severe anorexia nervosa. Researchers will give FMT capsules to 20 participants to see if changing their gut bacteria improves their metabolism, immune system, and harmful thoughts about food an…

This study is testing whether using two surgical implants works better than one to fix broken thigh bones near the knee in older or medically fragile adults. It's a small, early study to see if a larger trial is possible and to check if the two-implant method is safe and helps pe…

This study aims to find the best surgical method for treating unstable ankle fractures in frail adults aged 60 and older. Researchers will compare two procedures: one is the current standard surgery (ORIF), and the other is a newer approach using a special nail (retrograde nailin…

This study is comparing two methods to control pain after total hip replacement surgery. It will test if a newer ultrasound-guided nerve block (called a PENG block) works as well as the current standard method, which is an injection of numbing medicine during surgery. The study a…

This study aims to find the best way to manage pain after a common type of minimally invasive lung surgery (VATS). Researchers are comparing two nerve-blocking techniques to see which one leads to a better overall recovery experience for patients in the first 24 hours after surge…

This study aims to understand when brain activity stops compared to when the heart stops in patients who are taken off life support. Researchers will monitor electrical brain activity in 158 ICU patients as they progress toward death. The goal is to gather evidence about brain fu…

This study aims to understand the biology of life-threatening conditions like sepsis and ARDS by observing 1,000 critically ill patients in the ICU. Researchers will collect blood and fluid samples to identify early biological signs that could lead to faster diagnosis and better …