London Health Sciences Centre Research Institute Or Lawson Research Institute Of St. Joseph's

This study looks at whether using two implants instead of one to fix a broken thigh bone near the knee helps older or medically compromised adults recover better. About 44 participants will be randomly assigned to one of two treatments and followed for a year. The main goal is to…

This study tests whether giving heparin (a blood thinner) during heart catheterization through the wrist can prevent the wrist artery from closing up afterward. About 1,600 adults will be randomly assigned to receive no heparin, a low dose, or a high dose. The main goal is to see…

This study is for people with stage 2 or 3 breast cancer. It tests whether giving a special type of radiation (SBRT) and an immunotherapy drug (pembrolizumab) directly into the tumor before standard chemotherapy can help shrink the cancer more effectively. The goal is to see if t…

This study tests whether giving high-precision radiation (SABR) to every visible tumor can help people with 11 or more metastases live longer. About 138 adults with metastatic cancer will be randomly assigned to either standard care or SABR to all disease sites. The goal is to se…

This study tests a treatment called SMART, which uses movement and body awareness to help adults with PTSD. 80 participants will attend 8 sessions and complete assessments before, after, and 3 months later. The goal is to see if this approach reduces PTSD symptoms and improves bo…

This study compares two methods of pain relief for people having lung surgery with small incisions (VATS). One group gets a single nerve block, the other gets that block plus a continuous infusion through a small tube. The goal is to see if the combination leads to better recover…

This study tests if a nerve block (PENG block) works as well as the usual painkiller injection for hip replacement surgery. About 60 adults getting hip replacement will be randomly assigned to one of the two pain relief methods. Researchers will measure pain levels and muscle str…

This study looks at two different surgeries for unstable ankle fractures in frail adults aged 60 and older. One group gets ankle fusion, the other gets plates and screws. The goal is to see which surgery leads to better quality of life and less pain one year after the injury.

This study tests whether taking L-Carnitine by mouth can improve symptoms, heart function, and quality of life in people with heart failure who also have kidney problems. About 20 adults will take the supplement and be monitored for side effects and benefits. The goal is to see i…

This study watches brain activity in adults who are taken off life support in the ICU. Researchers want to learn exactly when the brain stops working compared to when the heart stops. About 158 patients will take part. The goal is to better understand the process of dying, not to…

This study is testing whether fecal microbiome transplants (FMT) can help people with anorexia nervosa by changing their gut bacteria. The researchers want to see if this treatment is safe and tolerable for 20 adults with anorexia. They will also look at how FMT affects thinking,…

This study watches 20 people on dialysis to see when they start drinking fluids after a session and how that affects weight gain between treatments. The goal is to understand if thirst right after dialysis leads to more fluid intake. This is an observation-only study, not a treat…

This study is observing 1,000 adults in the intensive care unit (ICU) to learn more about why some people get very sick from infections or injuries. Researchers will collect blood samples and health data to find early signs that could help diagnose serious conditions like sepsis …

This study is testing a digital app called VIRTUES to help people with heart conditions manage their health at home. The app provides personalized recommendations on medications, diet, exercise, and more. Researchers will enroll 2000 participants to use the app for one month and …

This study looks at whether high-intensity exercise done during hemodialysis (a treatment for kidney failure) can protect the heart from the stress of the procedure. Researchers will monitor heart function in 15 adults on dialysis. The goal is to see if more intense exercise offe…