London Health Sciences Centre Research Institute Or Lawson Research Institute Of St. Joseph's

This study tests a new wearable device that gently removes extra fluid between dialysis sessions. Many dialysis patients struggle with rapid fluid removal during treatment, which can damage the heart and brain. The device aims to safely remove leftover fluid at home, reducing har…

This study looks at whether people who had carpal tunnel release surgery on both hands between 2010 and 2015 might have an undiagnosed heart condition called cardiac amyloidosis. The condition involves protein buildup that stiffens the heart. Participants aged 55 and older will g…

This study tests a new PET scanner designed specifically for the prostate. Researchers want to see if it can find prostate cancer more clearly than standard whole-body scans. About 25 men with known or suspected prostate cancer will get both a standard scan and the new scan, and …

This study aims to speed up Alzheimer's diagnosis by using blood tests, spinal taps, and brain scans. Researchers will compare a nurse-led screening tool to standard specialist appointments. About 200 people with mild memory problems will take part to see if the new approach redu…

This study tests whether Meta AI glasses, combined with the Be My Eyes network, can help people with permanent vision loss navigate better and reduce falls. Fifty participants with conditions like glaucoma or retinal disease will use the glasses for real-time scene descriptions a…

This study looks at whether meditation or a health education program can improve quality of life and mental health for people with irreversible age-related vision loss and their caregivers. About 150 participants (patients aged 60-85 and caregivers aged 18-85) will be assigned to…

This study will test a program called Facing Your Fears, which is a type of therapy that helps children with autism learn to cope with anxiety. The study includes 24 teenagers aged 12 to 18 who have both autism and an intellectual disability. The goal is to see if the program is …

This study tests whether a numbing injection near the cheekbone can control pain after tonsil removal in children, reducing the need for strong opioid painkillers. Sixty children aged 3 to 9 having tonsil surgery for sleep apnea will be randomly assigned to receive either the ner…

This study looks at whether people with epilepsy digest food and liquids differently before surgery, even after following standard fasting rules. Researchers will use a quick, painless ultrasound scan of the stomach in 30 adults with epilepsy scheduled for surgery. The goal is to…

This study looks at why some people have pain that lasts more than 3 months after chest surgery. Researchers will check blood samples from 60 adults before and after surgery to see if certain molecules (cytokines) and gene changes (DNA methylation) are linked to long-term pain. T…

This study looks at whether the bacteria in your gut can influence how well a knee replacement works. Researchers will compare the gut bacteria of 30 people with successful knee replacements to those who need a second surgery. The goal is to understand if differences in gut bacte…

This study looks at how desmopressin, a drug that helps blood clot, affects platelet function in 100 adults having heart surgery with a heart-lung machine. Researchers will use a special blood test called TEG6s to measure clotting at different times. The goal is to better underst…

This study looks at how well a current gentamicin dosing plan works for newborns up to 7 days old who have early-onset sepsis. Researchers will measure drug levels in the blood and check for kidney or hearing side effects. The goal is to confirm that giving the antibiotic less of…

This study looks at whether measuring the optic nerve sheath (the protective layer around the nerve at the back of the eye) using ultrasound can help predict delirium—sudden confusion or agitation—after heart surgery. Researchers will monitor 300 adults undergoing heart surgery a…