London Health Sciences Centre Research Institute Or Lawson Research Institute Of St. Joseph's

This study tests if pirfenidone, a drug used for lung scarring, can safely slow scar buildup in the windpipe of people with idiopathic subglottic stenosis (iSGS). About 40 adults will receive either pirfenidone or a placebo for one year, alongside their usual steroid injections. …

This study tests a new wearable device that gently removes extra fluid between dialysis sessions. Many dialysis patients struggle with fluid buildup because standard treatments remove it too quickly, causing heart and brain damage. The device is worn at home for a few hours after…

This study looks for early signs of a heart condition called cardiac amyloidosis in people who have had carpal tunnel surgery on both hands. Researchers will use a special heart scan to check for abnormal protein buildup. The goal is to find the disease earlier so treatment can s…

This study tests a new PET scanner built specifically to image the prostate. Researchers want to see if it can detect prostate cancer more clearly than standard whole-body PET scans. About 25 men with known or suspected prostate cancer will receive both scans, and the images will…

This study tests a faster way to diagnose Alzheimer's disease using blood tests, spinal taps, and brain scans. It involves 200 people aged 50-90 with mild memory problems. The goal is to see if a nurse-led screening tool can help get a diagnosis in months instead of over a year.

This study tests whether using a personalized medicine clinic to tailor antidepressant doses can improve depressive symptoms. Researchers will enroll 200 adults with depression and track changes using a standard depression survey. The goal is to see if customizing medication base…

This study tests whether a device that gently stimulates a nerve in the ear (taVNS) can safely reduce chronic musculoskeletal pain in adults with cerebral palsy. Thirty-two participants will use either the active device or a sham (inactive) version at home for 30 days. Researcher…

This pilot study tests whether a small device that gently stimulates a nerve in the ear can safely reduce nerve pain in people with spinal cord injury. 32 adults will use the device at home for 30 days. The main goal is to see if the treatment is practical and well-tolerated, whi…

This study tests whether meditation or a health education program can improve quality of life and mental health for people with irreversible age-related vision loss and their caregivers. About 150 participants will be assigned to either meditation training or health classes, both…

This study tests whether Meta AI glasses, connected to the Be My Eyes network, can help people with permanent vision loss walk and move around more easily. The glasses describe scenes and objects in real time. Fifty participants will use the glasses and report changes in their qu…

This study tests whether a nerve block (injecting numbing medicine near the cheekbone) can control pain after tonsillectomy in children aged 3-9, reducing the need for opioids. Sixty kids having tonsil surgery for sleep apnea will be randomly assigned to get either the nerve bloc…

This pilot study will test whether a program called Facing Your Fears can help reduce anxiety in 24 children aged 12-18 who have both autism spectrum disorder and intellectual disability. The program uses cognitive behavioral therapy techniques like gradual exposure to feared sit…

This pilot study looks at whether it is safe to stop giving antibiotics after surgery for a burst (perforated) appendix. About 100 adults will be randomly assigned to receive either antibiotics or no antibiotics after their operation. The main goal is to see if a larger study is …

This study tests whether a structured, supervised exercise program can help adults recover from serious leg fractures. About 40 people who had surgery for a broken thigh or shin bone will either do the exercise program or get usual care. The main goal is to see if the program is …

This study looks at whether people with epilepsy digest food and liquids at a normal rate after following standard pre-surgery fasting rules. Researchers will use a quick, painless bedside ultrasound to check the stomach contents of 30 adults with epilepsy before their scheduled …

This study looks at whether measuring the optic nerve sheath (the covering of the nerve at the back of the eye) using ultrasound can help predict delirium—sudden confusion or agitation—after heart surgery. Researchers will monitor 300 adults before and after their operation. The …

This study looks at whether the bacteria in your gut (the gut microbiome) is different in people whose knee replacements fail versus those whose knees work well. Researchers will compare gut bacteria in 30 patients needing repeat knee surgery to those with successful implants. Th…

This study looks at how desmopressin, a drug that helps blood clot, affects platelet function in 100 adults undergoing heart surgery with a heart-lung machine. Researchers will use a special blood test called TEG6s to measure clotting at several time points before and after givin…

This pilot study looks at why some people develop chronic pain after chest surgery. Researchers will collect blood samples from 60 patients before and after surgery to measure certain molecules (cytokines) and check if changes in gene activity (epigenetics) are linked to long-ter…