London Health Sciences Centre Research Institute Or Lawson Research Institute Of St. Joseph's

This study tested a new, precise radiation treatment called SABR in 13 adults with metastatic cancer that had spread to more than 10 spots in the body. The goal was to see if it is safe and to find the best dose. Researchers hope this approach can better control cancer while caus…

This study tested giving focused radiation to the tumor area before breast cancer surgery, instead of the usual 5-6 weeks of radiation after surgery. 139 women with early-stage breast cancer received either one or three doses of this pre-surgery radiation. The goal was to see if …

This study tested whether virtual reality (VR) can reduce pain and distress in children with cancer during port-a-cath needle access. 84 children aged 5-17 who reported some fear before the procedure took part. Researchers measured their distress and pain levels during the needle…

This study examined health records of 5,000 older adults with low kidney function who started taking nortriptyline, an antidepressant. Researchers compared those on higher doses (over 10 mg/day) to those on a low dose (10 mg/day) to see if they had more emergency visits, hospital…

This study looked at 50,000 living kidney donors in Canada to see if they have a higher risk of heart problems or death later in life compared to similar people who didn't donate. Researchers used health records from 1992 to 2024 to track heart attacks, strokes, and deaths. The g…

This study looked at whether people who donate a kidney have a higher risk of breaking bones later in life. Researchers compared 50,000 kidney donors to similar non-donors using health records from three Canadian provinces. The goal is to help doctors and donors make informed dec…

This study looked at over 12,000 older adults (65+) with low kidney function to see if starting a higher dose (10 mg/day) of the antidepressant escitalopram is riskier than a lower dose (5 mg/day). The goal was to compare rates of hospitalization, emergency visits, or death withi…

This study looked at over 12,000 older adults (age 66+) with low kidney function who started taking lorazepam, a common anxiety medication. Researchers compared those taking higher doses (more than 1 mg per day) to those on lower doses (0.5-1 mg per day) to see if they had a high…

This study reviewed health records of 14,000 older adults (66+) with advanced chronic kidney disease who started taking tamsulosin, a drug for prostate issues. Researchers compared those on a higher dose (0.8 mg/day) to those on a lower dose (0.4 mg/day) to see if the higher dose…

This study looked at over 7,000 older adults (65+) with reduced kidney function to see if starting a higher dose (20 mg/day) of the antidepressant citalopram is riskier than a lower dose (10 mg/day). Researchers checked for hospital visits, emergency department visits, or death w…

This study looked at health records of 15,000 men to see if those who had laparoscopic pyeloplasty (a type of kidney surgery) were more likely to later need surgery for a hydrocele (fluid buildup in the scrotum). Researchers compared these men to similar men who did not have the …

This study looked at health records of 40,000 men in Ontario, Canada, to see if those who had kidney cancer surgery were more likely to develop a scrotal hydrocele (fluid-filled swelling) compared to men who didn't have the surgery. Researchers compared different surgical approac…

This study compared nearly 10,000 male kidney donors to similar non-donors to see if donating a kidney increases the chance of needing scrotal surgery years later. Researchers looked at hospital records and doctor bills to track surgeries for fluid collections in the scrotum. The…

This completed study looked at 1,100 older adults (65+) with advanced chronic kidney disease who started taking pramipexole, a drug for restless legs or Parkinson's. Researchers compared higher starting doses to a very low dose to see if there was a greater risk of hospitalizatio…

This study looked at 50,000 living kidney donors in Canada to see if they develop gout more often than similar people who did not donate a kidney. Researchers used health records to track gout diagnoses and related medications over many years. The goal is to help doctors and pote…

This study examined over 31,000 older adults (65+) with chronic kidney disease to see if starting a higher dose of the sleep medication trazodone (75-150 mg/day) increases the risk of hospitalization, emergency visits, or death within 30 days compared to a lower dose (25-75 mg/da…

This study looked at how the drug BYL719 changes certain proteins in head and neck cancer cells before surgery. Fifteen people with resectable head and neck cancer took BYL719 for a short time before their planned operation. Researchers compared tumor samples taken before and aft…

This study looked at whether starting a higher dose of two common antidepressants (venlafaxine and duloxetine) increases the chance of a serious event—like an emergency room visit, hospital stay, or death—within 30 days in older adults (66+) with chronic kidney disease. Researche…

This study reviewed health records of nearly 7,000 older adults (age 66+) with low kidney function to see if starting a higher dose (50 mg/day) of the antidepressant sertraline was riskier than a lower dose (25 mg/day). The researchers looked at whether people had to go to the ho…