London Health Sciences Centre Research Institute Or Lawson Research Institute Of St. Joseph's

This trial tested a new, shorter way to deliver radiation before breast cancer surgery. For early-stage breast cancer, standard radiation after surgery takes 5-6 weeks. This study compared giving just 1 dose versus 3 doses of targeted radiation *before* surgery to see if it could…

This study tested whether a precise, high-dose radiation technique called SABR is safe for people whose cancer has spread to more than 10 places in the body. It involved 13 patients with advanced metastatic cancer who had run out of standard treatment options. The main goal was t…

This study tested whether using virtual reality (VR) headsets could help reduce pain, fear, and distress for children with cancer during routine port-a-cath needle access. Port access is a common but often painful procedure where a needle is inserted through the skin to deliver m…

This study looked at whether starting older adults with reduced kidney function on a higher dose (50mg) of the antidepressant sertraline is riskier than starting on a lower dose (25mg). Researchers analyzed health records from over 6,800 adults aged 66+ in Canada who were newly p…

This study aimed to understand how a drug called BYL719 affects head and neck cancer tumors. Fifteen patients scheduled for surgery took the drug daily for two weeks before their operation. Researchers then compared tumor samples taken before and after the drug to see what biolog…

This study looked at the safety of two different starting doses of the antidepressant citalopram in adults aged 66 and older who have reduced kidney function. Researchers analyzed health records of over 7,000 people to see if starting on a 20mg daily dose led to more hospital vis…

This study looked at whether a higher dose of the prostate medication tamsulosin is riskier than a lower dose for older adults with advanced kidney disease. Researchers analyzed health records of 14,000 men in Ontario, Canada, comparing those who started on a high dose versus a s…

This study looked at whether men who had a specific kidney surgery (laparoscopic pyeloplasty) were more likely to later need surgery for a hydrocele, a fluid buildup in the scrotum. Researchers analyzed health records from over 15,000 men in Ontario, Canada, comparing those who h…

This study aims to find out if people who donate a kidney have a higher long-term risk of breaking bones, like hip or wrist fractures, compared to similar healthy people who did not donate. Researchers will review over 30 years of health records from 50,000 living kidney donors a…

This study looked at whether starting a higher dose of the anxiety/sleep medication lorazepam is riskier than a lower dose for older adults with poor kidney function. Researchers analyzed health records of over 12,000 people aged 66+ in Canada. They compared the chance of being h…

This study looked at the safety of two different starting doses of a common antidepressant, escitalopram, in adults over 65 with reduced kidney function. Researchers analyzed health records of over 12,000 people to see if starting on a 10 mg daily dose led to more hospital visits…

This study looked at whether starting a higher dose of the medication pramipexole is riskier than a lower dose for older adults with advanced kidney disease. Researchers analyzed health records of over 1,100 people in Canada to see if the higher dose was linked to more hospital v…

This study looked at whether starting a higher dose of the sleep and depression medication trazodone is riskier than a lower dose for older adults with reduced kidney function. Researchers analyzed health records of over 31,000 people aged 66 and older in Ontario. They compared t…

This study aims to understand the long-term heart health and survival of people who donate a kidney. Researchers will compare health records of 50,000 living kidney donors in Canada to a carefully matched group of healthy people who did not donate. The goal is to see if donors ha…

This study investigates whether men who donate a kidney through laparoscopic surgery have a higher long-term risk of needing scrotal surgery compared to similar men who didn't donate. Researchers analyzed health records of 9,878 men in Ontario, Canada, comparing about 800 kidney …