London Health Sciences Centre Research Institute Or Lawson Research Institute Of St. Joseph's

This study tested giving focused radiation before breast cancer surgery instead of the usual 5-6 weeks after surgery. 139 women with early-stage breast cancer received either one or three doses of radiation before their lumpectomy. The goal was to see if this approach can prevent…

This study tested a new radiation technique called SABR in 13 adults with cancer that had spread to more than 10 spots in the body. The goal was to see if giving high-dose, precise radiation to all cancer sites is safe. Researchers looked for side effects and quality of life chan…

This study tested whether virtual reality (VR) can reduce pain and distress in children with cancer when they get a needle put into their port-a-cath. 84 children aged 5 to 17 were randomly assigned to use VR, an iPad, or no special distraction during the procedure. Researchers m…

This study looks at why people on dialysis for kidney failure often have dangerous heart rhythms. Researchers implanted a small heart monitor in 18 patients to track their heartbeats for up to three years. They also used CT scans and ultrasound to see if the dialysis procedure it…

This completed study looked at 5000 older adults (66+) with low kidney function who started taking the antidepressant nortriptyline. Researchers compared those taking more than 10 mg per day to those taking exactly 10 mg per day to see if higher doses increased the chance of an e…

This study looked at health records of 15,000 males in Ontario, Canada, to see if those who had laparoscopic pyeloplasty (a surgery to fix a blocked kidney) were more likely to later need surgery for a hydrocele (a fluid-filled sac in the scrotum). Researchers compared these pati…

This study reviewed health records of 40,000 men in Ontario, Canada, to see if those who had kidney cancer surgery (nephrectomy) were more likely to develop a hydrocele—a fluid-filled sac in the scrotum. Researchers compared men who had laparoscopic or open surgery to similar men…

This study examined whether starting a higher dose of two common antidepressants (venlafaxine and duloxetine) increases the risk of emergency visits, hospital stays, or death within 30 days in older adults with chronic kidney disease. Researchers analyzed health records from over…

This study looked at 50,000 living kidney donors in Canada to see if they are more likely to develop kidney stones years after donating, compared to similar people who never donated. Researchers used health records from 1992 to 2024 to track surgeries or hospital visits for kidne…

This study looked at whether people who donate a kidney have a higher chance of developing gout later in life compared to similar healthy people who did not donate. Researchers reviewed health records from 50,000 donors and matched non-donors in Canada over many years. The goal i…

This study compared 50,000 living kidney donors to similar healthy non-donors to see if donating a kidney raises the long-term risk of heart attack, stroke, or death. Researchers looked at health records from 1992 to 2024 in three Canadian provinces. The goal is to help doctors a…

This study examined over 31,000 older adults (65+) with chronic kidney disease to see if starting a higher dose of the sleep medication trazodone (75-150 mg/day) leads to more serious events like hospital visits or death within 30 days compared to a lower dose (25-75 mg/day). The…

This completed study compared nearly 10,000 male living kidney donors to similar non-donors to see if laparoscopic nephrectomy increases the long-term chance of needing scrotal surgery, such as for fluid collections. Researchers used health databases in Ontario, Canada, tracking …

This study examines whether people who donate a kidney have a higher long-term risk of breaking bones like the hip, wrist, or pelvis. Researchers will compare 50,000 living kidney donors from Canada to a matched group of healthy non-donors using health records from 1992 to 2024. …

This study looked at over 7,000 older adults (65+) with reduced kidney function who started taking the antidepressant citalopram. Researchers compared a 20 mg/day dose to a 10 mg/day dose to see if the higher dose increased the risk of serious events like hospitalization, emergen…

This completed study looked at 1,100 older adults (65+) with advanced chronic kidney disease who started taking pramipexole, a drug for restless legs or Parkinson's. Researchers compared a very low starting dose (0.125 mg/day) to slightly higher doses (0.25 or 0.375 mg/day) to se…

This completed study looked at nearly 7,000 older adults (65+) with low kidney function who started taking the antidepressant sertraline. Researchers compared the safety of a 50 mg daily dose versus a 25 mg daily dose, tracking hospital visits, emergency department visits, or dea…

This study looked at over 12,000 older adults (age 66+) with low kidney function who started taking the antidepressant escitalopram. Researchers compared the safety of a 10 mg daily dose versus a 5 mg daily dose. The goal was to see if the higher dose led to more hospital visits,…

This study tested whether taking the drug BYL719 (Alpelisib) for 14 days before surgery could change certain biological markers in head and neck cancer tissue. Fifteen patients with resectable head and neck squamous cell cancer took the drug, and researchers compared tissue sampl…

This study looked at 14,000 older adults (66+) with advanced chronic kidney disease who started taking tamsulosin. Researchers compared those on a higher dose (0.8 mg/day) to those on a lower dose (0.4 mg/day) to see if the higher dose led to more hospital visits or deaths within…

This completed study looked at over 12,000 older adults (66+) with low kidney function who started taking lorazepam. Researchers compared higher doses (1-4 mg/day) to lower doses (0.5-1 mg/day) to see if there was a greater risk of hospitalization, emergency visits, or death with…