Higher antidepressant dose may raise risks for seniors with weak kidneys
NCT ID NCT07387120
First seen Feb 04, 2026 · Last updated Jun 23, 2026 · Updated 19 times
Summary
This completed study looked at nearly 7,000 older adults (65+) with low kidney function who started taking the antidepressant sertraline. Researchers compared the safety of a 50 mg daily dose versus a 25 mg daily dose, tracking hospital visits, emergency department visits, or death within 30 days. The goal was to see if the higher dose poses greater risks in this vulnerable group.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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London Health Sciences Centre Research Institute
London, Ontario, Canada
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Sertraline
What this could lead to
If successful, this could help doctors choose safer antidepressant doses for older adults with kidney problems.
What could go wrong
This is an observational study, not a controlled trial, so it can show links but not prove cause and effect. Results may not apply to all patients.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.