Can a newer heart failure drug protect kidneys better than an older one?

NCT ID NCT07023016

Completed Disease control Sponsor: National Heart Institute, Egypt Source: ClinicalTrials.gov ↗

First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time

Summary

This trial tests whether sacubitril/valsartan, a newer heart failure medication, is safer and more effective for the kidneys than ramipril, an older ACE inhibitor, in people hospitalized with acute decompensated heart failure who also have chronic kidney disease. About 515 participants with reduced heart pumping function and moderate kidney impairment will receive one of the two drugs. The main goal is to compare changes in kidney function (eGFR) after 12 weeks, with additional monitoring for worsening kidney function and high potassium levels.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Sacubitril/valsartan (a combination drug) compared to ramipril (an ACE inhibitor)
What this could lead to: If sacubitril/valsartan proves safer and more effective for the kidneys, it could become a preferred treatment for heart failure patients with chronic kidney disease.
What could go wrong: This is a mid-stage trial, and results may not confirm an advantage. Risks include worsening kidney function, high potassium levels, and low blood pressure.

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Conditions

The condition(s) this trial relates to.

chronic kidney disease chronic renal failure syndrome congestive heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE DECOMPENSATED HEART FAILURE (ADHF) CHRONIC KIDNEY DISEASE (CKD)

Contacts and locations

Locations

Cairo University Hospitals

Cairo, Egypt
National Heart Institute

Cairo, Egypt

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