Study reveals trazodone dosing dangers for seniors with kidney trouble

This study examined over 31,000 older adults (65+) with chronic kidney disease to see if starting a higher dose of the sleep medication trazodone (75-150 mg/day) leads to more serious events like hospital visits or death within 30 days compared to a lower dose (25-75 mg/day). The goal was to understand the safety of different trazodone doses in this vulnerable group. The study was observational, meaning it looked back at existing health records, and did not test a new treatment.