Antidepressant dose matters for seniors with weak kidneys
NCT ID NCT07274241
First seen Jan 03, 2026 · Last updated Jun 21, 2026 · Updated 26 times
Summary
This study looked at over 12,000 older adults (age 66+) with low kidney function who started taking the antidepressant escitalopram. It compared the safety of a 10 mg daily dose versus a 5 mg daily dose. The goal was to see if the higher dose led to more hospital visits or deaths within 30 days. The findings could help guide safer prescribing for this vulnerable group.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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London Health Sciences Centre Research Institute
London, Ontario, Canada
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Escitalopram (antidepressant) at 5 or 10 mg/day
What this could lead to
If it finds a safer dose, it could help doctors prescribe escitalopram more safely for older adults with kidney problems.
What could go wrong
This is an observational study, not a controlled trial, so it can only show links, not cause and effect. Results may not apply to all patients.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.