London Health Sciences Centre Research Institute Or Lawson Research Institute Of St. Joseph's

This study tests whether giving a small dose of targeted radiation to the tumor before standard chemotherapy can prime the immune system to better attack high-risk breast cancer. About 40 adults with locally advanced breast cancer will receive three radiation treatments, then pro…

This study tests a highly targeted form of radiation therapy (SABR) in people with early-stage non-small cell lung cancer who also have interstitial lung disease, a condition that makes the lungs stiff and scarred. The goal is to see if this precise radiation can control the canc…

This early-stage study tests a high-dose radiation technique called SBRT for people with non-small cell lung cancer located in the very center of the chest (ultra-central). The main goal is to find the highest safe dose that keeps the risk of serious side effects under 30% within…

This study looks at whether giving focused, high-dose radiation (SABR) to a small number of growing cancer spots can help people with advanced lung cancer stay stable longer. About 90 adults with non-small cell lung cancer that has spread and is growing in just a few places will …

This study tests whether giving a higher dose of radiation to the most active parts of a lung tumor can lower the chance of cancer coming back in the chest. About 78 adults with advanced non-small cell lung cancer will get either standard chemoradiotherapy or chemoradiotherapy pl…

This study looks at whether raising the magnesium level in the fluid used during dialysis can help people with end-stage kidney disease live longer and avoid heart-related hospital stays. Many dialysis patients have low magnesium, which is linked to higher risks of death, heart i…

This study compares a newer, more natural heart pacing method (left bundle branch area pacing) to the standard method (right ventricular pacing) in patients who develop heart block after a TAVR procedure. The goal is to see if the newer method improves heart function and reduces …

This study tests whether adding peritoneal dialysis (a type of dialysis using the belly lining) between regular hemodialysis sessions can safely remove extra sodium and fluid in 10 people with end-stage kidney disease. The goal is to improve fluid balance and reduce strain on the…

This early-phase study tests whether giving kidney cancer patients a fecal microbiota transplant (FMT) before and during immunotherapy can prevent severe side effects like colitis. About 20 adults with advanced kidney cancer will receive FMT alongside the drugs ipilimumab and niv…

This study compares two standard treatments for HPV-related throat cancer: radiation therapy or surgery. The goal is to see which approach leads to better survival and quality of life, especially swallowing function. About 61 adults with early-stage cancer are taking part. Result…

This study aimed to see if hydroxychloroquine (HCQ) could safely prevent COVID-19 in older adults living in long-term care homes who were at high risk. It planned to give the drug to people after they were exposed to the virus. However, the study was withdrawn before any particip…

This pilot study tests whether a group therapy program called Awareness, Courage, and Love Groups can help reduce loneliness in older adults admitted to a psychiatric hospital. The program is based on a type of therapy called functional analytic psychotherapy. The study will enro…

This study tests a group therapy program called Awareness, Courage, and Love (ACL) for older adults with mental health conditions who feel lonely. About 50 participants will attend 8 group sessions to see if the program is practical and helps reduce loneliness. The goal is to imp…

This study tests a therapy called Deep Brain Reorienting (DBR) for people with post-traumatic stress disorder (PTSD). 234 adults will be randomly assigned to receive DBR or join a waitlist. The goal is to see if DBR reduces PTSD symptoms like distress and flashbacks.

This study looks at why people on dialysis for kidney failure often have dangerous heart rhythms. Researchers are using a small implantable device to track heart activity and combining that with heart scans. The goal is to understand how dialysis may injure the heart and trigger …

This study looks at whether a special MRI that measures salt (sodium) in the kidneys can help doctors predict if heart failure patients will become resistant to water pills (diuretics). About 50 adults with heart failure and kidney disease will have their kidney salt levels scann…

This study aimed to compare a less invasive procedure called vacuum-assisted percutaneous excision (VAPE) with standard surgery for removing non-cancerous but high-risk breast lesions. It was designed for women over 18 with certain breast conditions that usually require surgical …

This study aims to find genetic and blood markers that can predict which breast cancer patients will have severe side effects or poor response to a class of drugs called kinase inhibitors. Researchers will analyze DNA and blood samples from 100 women with breast cancer who are ta…

This study looks at how dialysis treatments affect blood flow in the brains of people with chronic kidney failure. Researchers will measure brain blood vessel response to carbon dioxide before and after dialysis sessions. The goal is to find ways to adjust dialysis to better prot…