London Health Sciences Centre Research Institute Or Lawson Research Institute Of St. Joseph's

This pilot study tests whether adding a special type of dialysis (peritoneal dialysis) between regular hemodialysis sessions can remove extra sodium and fluid from the body. Ten adults on hemodialysis will receive this extra treatment twice a week for three weeks. Researchers wil…

This study looks at whether adding more magnesium to the fluid used during dialysis can help people with kidney failure live longer and have fewer heart-related hospital stays. Many dialysis patients have low magnesium, which can lead to muscle cramps and heart issues. The trial …

This trial is testing whether giving a small dose of targeted radiation to a part of the breast tumor before standard chemotherapy can help the immune system fight the cancer more effectively. The study includes 40 people with high-risk or locally advanced breast cancer. After ra…

This study compares two standard treatments—radiation therapy and surgery—for people with HPV-related throat cancer. The goal is to see which approach provides better survival and quality of life. About 61 adults with early-stage cancer are taking part to help guide future treatm…

This study looks at whether giving precise, high-dose radiation to a small number of growing cancer spots can help people with metastatic non-small cell lung cancer stay stable longer. About 90 adults whose cancer has started to grow in just a few places while on standard treatme…

This trial tests whether giving a higher radiation dose to the most active parts of a lung tumor can better control the cancer. About 78 people with locally advanced non-small cell lung cancer will receive either standard chemoradiation or chemoradiation with an extra radiation b…

This phase 1 trial tests a precise, high-dose radiation technique called SBRT for patients with non-small cell lung cancer whose tumors are located in the ultra-central part of the chest, near the windpipe and major blood vessels. The study enrolls 30 participants to find the hig…

This phase II trial tests a precise type of radiation called SABR in 39 people with early-stage non-small cell lung cancer who also have interstitial lung disease (lung scarring). The goal is to see if this treatment can control the cancer while keeping side effects manageable. P…

This early-stage trial tests whether taking capsules containing processed stool from healthy donors can prevent severe immune-related side effects in people with advanced kidney cancer receiving a combination of two immunotherapy drugs (ipilimumab and nivolumab). The study involv…

This study aimed to see if hydroxychloroquine could prevent COVID-19 in older adults living in long-term care homes. It planned to give either the drug or a placebo to high-risk residents after they were exposed to the virus. However, the trial was withdrawn before enrolling anyo…

This study tests a therapy called Deep Brain Reorienting (DBR) for people with PTSD. DBR helps patients focus on physical tension linked to traumatic memories. 234 adults will be randomly assigned to either DBR or a waitlist, and researchers will measure changes in PTSD symptoms.

This study tests a group therapy called Awareness, Courage, and Love (ACL) for older adults with psychiatric disorders who feel lonely. The therapy focuses on mindfulness, sharing feelings, and building connections. Researchers want to see if the program is practical and helpful …

This pilot study tests whether a group therapy called Awareness, Courage, and Love Groups can help reduce loneliness in older adults admitted to a psychiatric hospital. Fifty participants will attend either this therapy or a standard mutual-help group. Researchers will measure so…

This study looks at whether measuring salt levels in the kidneys using a special MRI can help doctors predict which heart failure patients will not respond well to water pills (diuretics). About 50 adults with heart failure and kidney disease will be scanned to compare salt conte…

This study looks at how kidney dialysis affects brain blood flow in 37 adults with chronic kidney failure. Researchers use a special breathing device called RespirAct to measure the brain's response to carbon dioxide before and after dialysis sessions. The goal is to find ways to…

This study looks at whether high-intensity cycling during hemodialysis can protect the heart from damage that dialysis sometimes causes. Fifteen adults on dialysis will exercise at different intensities during their sessions. Researchers will use echocardiograms to measure heart …

This study was designed to compare a newer pacing method (left bundle branch area pacing) with the standard method (right ventricular pacing) in patients who developed heart block after TAVR valve replacement. The goal was to see which method better preserves heart function and r…

This study aimed to compare a less invasive procedure called vacuum-assisted excision (VAPE) to standard surgery for removing non-cancerous but high-risk breast lesions. The goal was to see if VAPE worked as well, was safer, and left better cosmetic results. However, the study wa…

This study looks at 100 breast cancer patients taking CDK4/6 inhibitor drugs. Researchers want to find genetic and blood markers that can predict who will have bad side effects or not get enough benefit from the medication. The goal is to help doctors choose safer and more effect…