New radiation approach aims to safely treat Hard-to-Reach lung tumors

NCT ID NCT03306680

Ongoing Disease control Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This phase 1 trial tests a precise, high-dose radiation technique called SBRT for patients with non-small cell lung cancer whose tumors are located in the ultra-central part of the chest, near the windpipe and major blood vessels. The study enrolls 30 participants to find the highest safe dose that keeps the risk of serious side effects under 30% within two years. Researchers will also track cancer progression, survival, and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: radiation therapy (SBRT)
What this could lead to: If successful, this could establish a safer radiation dose for hard-to-treat lung tumors located near the center of the chest.
What could go wrong: This is an early-phase trial with only 30 participants, so results may not apply broadly. The main risk is serious side effects from radiation hitting nearby vital structures.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

BC Cancer -Vancouver Island

Vancouver, British Columbia, V8R 6V5, Canada
Centre Hospitalier de l'Universite de Montreal (CHUM)

Montreal, Quebec, H2X 0A9, Canada
London Regional Cancer Program

London, Ontario, N6A 4L6, Canada
McGill University Health Centre-Cedars Cancer Centre

Montreal, Quebec, H4A 3J1, Canada
Princess Margaret Cancer Centre

Toronto, Ontario, M5G 1X6, Canada
Saskatoon Cancer Centre

Saskatoon, Saskatchewan, S7S 0B1, Canada
Sunnybrook Odette Cancer Centre

Toronto, Ontario, M4N 3M5, Canada

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