Poop pills may prevent dangerous side effects of cancer immunotherapy
NCT ID NCT04163289
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This early-stage trial tests whether taking capsules containing processed stool from healthy donors can prevent severe immune-related side effects in people with advanced kidney cancer receiving a combination of two immunotherapy drugs (ipilimumab and nivolumab). The study involves 20 participants who will take the fecal transplant capsules before and during their first two cycles of immunotherapy. The main goal is to see if this approach is safe and reduces the occurrence of serious colitis and other immune-related adverse events, helping patients stay on treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Fecal microbiota transplantation (FMT) capsules from healthy donors
- What this could lead to
- If it works, this approach could help patients tolerate powerful immunotherapy combinations better, allowing them to continue treatment and potentially improve outcomes.
- What could go wrong
- This is a very early phase 1 trial with only 20 participants, so results may not apply broadly. The safety and effectiveness of FMT for this purpose are still unknown.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
London Regional Cancer Program of the Lawson Health Research Institute
London, Ontario, N6A 5W9, Canada
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a Two-Drug combo outsmart advanced cancers?
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- Can a new nucleotide analogue boost cancer treatment?
- Can a blast of radiation make immunotherapy work better against kidney cancer?
- Can reprogrammed immune cells take on hard-to-treat kidney cancer?