New PET scan technique could map hidden prostate cancer recurrences

NCT ID NCT03718260

Completed Diagnosis Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's Source: ClinicalTrials.gov ↗

First seen Jul 17, 2026 · Last updated Jul 17, 2026

Summary

This large registry study is testing whether a special type of PET scan, called PSMA-PET, can better detect where prostate cancer has returned after initial treatment. Thousands of men with suspected recurrent prostate cancer across Ontario will receive this scan. The goal is to see how often the scan finds cancer that standard imaging misses, and whether this information helps doctors choose more personalized treatments like targeted radiation or surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PSMA-PET scan using [18F]-DCFPyL or [18F]PSMA-1007
What this could lead to: If successful, this registry could show that PSMA-PET scans find recurrent prostate cancer more accurately than standard imaging, helping doctors tailor treatments like targeted radiation or surgery to each person's specific pattern of spread.
What could go wrong: This is an observational registry, not a controlled trial, so it cannot prove that using PSMA-PET improves outcomes like survival. The scans may also detect lesions that are not clinically significant, leading to unnecessary procedures.

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Conditions

The condition(s) this trial relates to.

prostate cancer prostate carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RECURRENT PROSTATE CANCER

Contacts and locations

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Locations

London Health Sciences Centre

London, Ontario, N6A 5W9, Canada
Princess Margaret Cancer Centre, University Health Network

Toronto, Ontario, M5G 2M9, Canada
St. Joseph's Healthcare Hamilton

Hamilton, Ontario, L8N 4A6, Canada
The Ottawa Hospital, General Campus

Ottawa, Ontario, K1H 8L6, Canada
Thunder Bay Regional Health Sciences Centre

Thunder Bay, Ontario, P7B 6V4, Canada
Toronto Sunnybrook Cancer Centre

Toronto, Ontario, M4N 3M5, Canada
Windsor Regional Hospital

Windsor, Ontario, Canada

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