Antidepressant dose linked to hospital risk in seniors with kidney trouble
NCT ID NCT07527481
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed study looked at 5000 older adults (66+) with low kidney function who started taking the antidepressant nortriptyline. Researchers compared those taking more than 10 mg per day to those taking exactly 10 mg per day to see if higher doses increased the chance of an emergency room visit, hospitalization, or death within 30 days. The goal is to find safer prescribing practices for this vulnerable group.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Nortriptyline (a tricyclic antidepressant)
- What this could lead to
- If successful, this could help doctors prescribe nortriptyline more safely for older adults with kidney problems.
- What could go wrong
- This is an observational study, not a controlled trial, so it can show links but not prove cause and effect. Results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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