A new pill aims to slow kidney failure and save lives

NCT ID NCT07753993

Not yet recruiting Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time

Summary

This phase III trial is testing whether an experimental drug called elecoglipron can reduce the risk of serious kidney decline, kidney failure, or death in people with chronic kidney disease. About 7,000 adults with the condition, with or without type 2 diabetes, will receive either elecoglipron or a placebo alongside their standard treatments. The study will track how long it takes for participants to experience a major kidney event or death, to see if the drug offers meaningful protection.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: elecoglipron (an investigational drug taken as a tablet)
What this could lead to: If successful, elecoglipron could offer a new way to slow kidney failure and reduce deaths in people with chronic kidney disease.
What could go wrong: This is an early-stage test in a large group; the drug may not prove effective or may cause side effects. Results are not yet known.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic kidney disease chronic renal failure syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC KIDNEY DISEASE

Contacts and locations

Locations

Research Site

Sheffield, Alabama, 35660, United States
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Surprise, Arizona, 85374, United States
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Chula Vista, California, 91910, United States
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Waterbury, Connecticut, 06708, United States
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Chicago, Illinois, 60611, United States
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Topeka, Kansas, 66606, United States
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Beltsville, Maryland, 20705, United States
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Boston, Massachusetts, 02115, United States
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Troy, Michigan, 48098, United States
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Edina, Minnesota, 55435, United States
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Saint Paul, Minnesota, 55117, United States
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Eatontown, New Jersey, 07724, United States
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Albany, New York, 12205, United States
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Buffalo, New York, 14215, United States
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Mineola, New York, 11501, United States
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Morehead City, North Carolina, 28557, United States
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Shelby, North Carolina, 28150, United States
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Statesville, North Carolina, 28625, United States
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Wilmington, North Carolina, 28401, United States
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Wilmington, North Carolina, 28403, United States
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Maumee, Ohio, 43537, United States
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Rapid City, South Dakota, 57701, United States
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Knoxville, Tennessee, 37912, United States
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Morristown, Tennessee, 37813, United States
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Arlington, Texas, 76015, United States
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Dallas, Texas, 75246, United States
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Houston, Texas, 77054, United States
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Lubbock, Texas, 79430, United States
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Mesquite, Texas, 75149, United States
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San Antonio, Texas, 78230, United States
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Shenandoah, Texas, 77384, United States
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South Salt Lake, Utah, 84115, United States
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Norfolk, Virginia, 23502, United States
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Buenos Aires, C1056, Argentina
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Buenos Aires, C1060AAB, Argentina
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Caba, C1128AAF, Argentina
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CABA, C1425HFA, Argentina
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Ciudad de Buenos Aires, 1128, Argentina
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Ciudad de Buenos Aires, C1094AAD, Argentina
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Córdoba, X5006CBI, Argentina
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La Plata, B1900, Argentina
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Mar del Plata, 7600, Argentina
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Mar del Plata, B7600, Argentina
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Rosario, 2000, Argentina
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Rosario, S2000CVD, Argentina
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San Nicolás, B2900DMH, Argentina
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Santa Rosa, 6300, Argentina
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Castle Hill, 2154, Australia
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Fitzroy, 3065, Australia
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Gosford, 2250, Australia
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Perth, 6000, Australia
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Southport, 4215, Australia
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Wollongong, 2500, Australia
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Barretos, 14784-400, Brazil
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Belém, 66073-005, Brazil
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Belo Horizonte, 30150-320, Brazil
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Bragança Paulista, 12916-542, Brazil
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Brasília, 71625-009, Brazil
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Campina Grande do Sul, 83.430-000, Brazil
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Campinas, 13060-080, Brazil
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Campinas, 13092133, Brazil
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Curitiba, 80810-040, Brazil
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Joinville, 89227-680, Brazil
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Natal, 59020-035, Brazil
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Porto Alegre, 90020-090, Brazil
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Porto Alegre, 9061-000, Brazil
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Porto Alegre, 90630-165, Brazil
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Presidente Prudente, 19050-680, Brazil
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São José dos Campos, 12230-001, Brazil
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São Paulo, 01228-000, Brazil
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São Paulo, 01327-001, Brazil
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São Paulo, 04038-031, Brazil
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São Paulo, 05403-9000, Brazil
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Plovdiv, 4000, Bulgaria
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Calgary, Alberta, T3R 1W9, Canada
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Edmonton, Alberta, T6G 2G3, Canada
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Vancouver, British Columbia, V5Y 3W2, Canada
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Winnipeg, Manitoba, R2V 3M3, Canada
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Toronto, Ontario, M4G 3E8, Canada
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Waterloo, Ontario, N2T 0C1, Canada
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Montreal, Quebec, H4J 1C5, Canada
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Araucania, 4781151, Chile
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Osorno, 5311092, Chile
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Region Metropolitana, 7550000, Chile
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Santiago, 7510187, Chile
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Santiago, 8330034, Chile
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Temuco, 4810345, Chile
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Victoria, 4720000, Chile
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Viña del Mar, 2540488, Chile
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Hradec Králové, 50005, Czechia
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Humpolec, 396 01, Czechia
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Jilemnice, 514 01, Czechia
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Liberec, 46014, Czechia
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Mariánské Lázně, 35301, Czechia
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Náchod, 547 01, Czechia
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Nové Město na Moravě, 692 31, Czechia
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Nový Jičín, 741 01, Czechia
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Ostrava, 70030, Czechia
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Prague, 100 34, Czechia
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Prague, 130 00, Czechia
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Prague, 160 00, Czechia
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Tábor, 390 03, Czechia
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Třebíč, 674 01, Czechia
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Aalborg, 9000, Denmark
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Aarhus, 8200, Denmark
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Copenhagen E, 2100, Denmark
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Herlev, 2730, Denmark
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Herning, 7400, Denmark
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Holbæk, 4300, Denmark
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Roskilde, 4000, Denmark
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Helsinki, 00290, Finland
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Jyväskylä, 40620, Finland
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Oulu, 90220, Finland
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Tampere, 33100, Finland
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Tampere, 33101, Finland
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Turku, 20100, Finland
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Ahrensburg, 22926, Germany
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Bad Mergentheim, 97980, Germany
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Bad Nenndorf, 31542, Germany
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Berlin, 10117, Germany
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Berlin, 10249, Germany
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Berlin, 10787, Germany
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Berlin, 12203, Germany
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Bonn, 53127, Germany
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Brandenburg an der Havel, 14770, Germany
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Braunschweig, 38126, Germany
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Chemnitz, 09116, Germany
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Cloppenburg, 49661, Germany
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Cuxhaven, 27472, Germany
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Dortmund, 44137, Germany
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Dresden, 1307, Germany
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Duisburg, 47269, Germany
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Erlangen, 91054, Germany
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Essen, 45122, Germany
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Frankfurt, 60596, Germany
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Frankfurt am Main, 60431, Germany
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Freiburg im Breisgau, 79110, Germany
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Fulda, 36037, Germany
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Gladbeck, 45968, Germany
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Goslar, 38642, Germany
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Göttingen, 37075, Germany
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Hamburg, 21109, Germany
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Hamburg, 22041, Germany
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Hamburg, 22143, Germany
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Hanover, 30159, Germany
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Hanover, 30625, Germany
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Herne, 44625, Germany
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Jerichow, 39319, Germany
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Kiel, 24105, Germany
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Landshut, 84034, Germany
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Leipzig, 04177, Germany
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Leipzig, 04179, Germany
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Lübeck, 23552, Germany
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Magdeburg, 39120, Germany
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Mainz, 55131, Germany
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Mannheim, 68167, Germany
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Nuremberg, 90443, Germany
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Nuremberg, 90471, Germany
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Reinfeld (Holstein), 23858, Germany
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Riesa, 01589, Germany
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Rostock, 18057, Germany
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Stuttgart, 70376, Germany
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Ulm, 89081, Germany
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Wiesbaden, 65189, Germany
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Würzburg, 97080, Germany
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Alexandroupoli, 68100, Greece
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Athens, 11527, Greece
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Athens, 12462, Greece
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Athens, 15125, Greece
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Chios, 82100, Greece
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Heraklion, 71500, Greece
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Ioannina, 45500, Greece
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Larissa, 41500, Greece
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Pátrai, 26504, Greece
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Thessaloniki, 54642, Greece
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Thessaloniki, 54645, Greece
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Thessaloniki, 57001, Greece
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Szeged, 6725, Hungary
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Chennai, 600037, India
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Ashkelon, 78278, Israel
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Be’er Ya‘aqov, 70300, Israel
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Hadera, 38100, Israel
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Haifa, 34362, Israel
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Holon, 58100, Israel
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Kfar Saba, 4428164, Israel
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Nahariya, 22100, Israel
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Ramat Gan, 52621, Israel
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Rehovot, 76100, Israel
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Tiberias, 15208, Israel
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Alessandria, 15100, Italy
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Bari, 70124, Italy
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Bologna, 40138, Italy
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Catania, 95125, Italy
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Chieri, 10023, Italy
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Cinisello Balsamo, 20092, Italy
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Cosenza, 87100, Italy
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Feltre, 32032, Italy
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Foggia, 71100, Italy
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Naples, 80131, Italy
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Pavia, 27100, Italy
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Pordenone, 33170, Italy
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Ranica, 24020, Italy
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Rome, 00189, Italy
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San Fermo della Battaglia, 22020, Italy
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San Giovanni Rotondo, 71013, Italy
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Trieste, 34149, Italy
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Aira, 899-5421, Japan
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Akita, 010-8543, Japan
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Asahikawa-shi, 070-8530, Japan
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Chūōku, 103-0002, Japan
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Fujisawa-shi, 251-0041, Japan
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Fukuoka, 814-0180, Japan
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Hachioji-shi, 192-0083, Japan
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Hamamatsu, 431-3192, Japan
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Hiroshima, 734-8551, Japan
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Ichikawa-shi, 272-8516, Japan
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Ina-shi, 396-8555, Japan
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Iruma-Gun, 350-0495, Japan
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Izunokuni-shi, 410-2295, Japan
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Kamakura-shi, 247-0056, Japan
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Kanazawa, 920-8650, Japan
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Kasuga-shi, 816-0864, Japan
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Kasugai-shi, 486-8510, Japan
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Kawachinagano-shi, 586-8521, Japan
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Kitakyushu, 802-8555, Japan
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Kitakyushu-shi, 802-0077, Japan
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Kumamoto, 862-0950, Japan
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Kurume, 830-8543, Japan
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Kuwana-shi, 511-0061, Japan
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Matsumoto-shi, 390-1401, Japan
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Minatoku, 108-0073, Japan
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Minokamo Shi, 505-8510, Japan
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Moriyama-shi, 524-8524, Japan
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Nagoya, 451-8511, Japan
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Nagoya, 468-0009, Japan
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Naka, 311-0113, Japan
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Naka, 311-0133, Japan
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Okayama, 700-0804, Japan
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Okayama, 700-8557, Japan
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Osaka, 558-8558, Japan
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Osaka, 559-0012, Japan
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Oyama-shi, 323-0022, Japan
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Ōita, 870-0039, Japan
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Sakaishi, 593-8304, Japan
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Sakushu, 385-8558, Japan
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Sapporo, 060-0062, Japan
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Sapporo, 062-0931, Japan
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Sasebo-shi, 857-8511, Japan
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Shinjuku-ku, 160-0023, Japan
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Suita-shi, 565-0871, Japan
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Suwa-shi, 392-8510, Japan
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Takasago-shi, 676-0812, Japan
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Tsu, 514-8507, Japan
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Ushiku-shi, 300-1207, Japan
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Utsunomiya, 321-0151, Japan
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Yokohama, 230-8765, Japan
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Yokohama, 234-0054, Japan
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Yokohama, 236-0004, Japan
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Ipoh, 30990, Malaysia
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Bergen, 5021, Norway
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Bodø, 8005, Norway
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Drammen, 3004, Norway
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Grålum, 1714, Norway
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Haugesund, 5528, Norway
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Levanger, 7601, Norway
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Lørenskog, 1478, Norway
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Oslo, 0369, Norway
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Oslo, 0450, Norway
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Oslo, 0456, Norway
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Oslo, 0586, Norway
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Skedsmokorset, N-2020, Norway
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Skien, 3710, Norway
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Stavanger, N-4011, Norway
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Tromsø, N-9038, Norway
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Trondheim, 7006, Norway
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Tønsberg, 3116, Norway
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Chorrillos, Lima 9, Peru
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Lima, 14, Peru
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Lima, 15082, Peru
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Lima, 15088, Peru
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Lima, LIMA 01, Peru
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Lima, LIMA 27, Peru
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Davao City, 8000, Philippines
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Davao City, PH-8000, Philippines
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Iloilo City, 5000, Philippines
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Las Piñas, 1742, Philippines
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Manadaluyong City, 1552, Philippines
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Pasig, 1605, Philippines
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Quezon City, 0870, Philippines
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Quezon City, 1101, Philippines
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Quezon City, 1112, Philippines
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Będzin, 42-500, Poland
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Bialystok, 15-481, Poland
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Czeladź, 41-250, Poland
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Gmina Świecie, 86-100, Poland
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Katowice, 40-648, Poland
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Kwidzyn, 82-500, Poland
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Lodz, 92-213, Poland
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Lublin, 20-011, Poland
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Olsztyn, 10-117, Poland
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Olsztyn, 10-561, Poland
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Poznan, 60-355, Poland
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Poznan, 61-251, Poland
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Rzeszów, 35-205, Poland
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Tczew, 83-110, Poland
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Warsaw, 00-719, Poland
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Warsaw, 04-141, Poland
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Włocławek, 87-800, Poland
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Żywiec, 34-300, Poland
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Bucharest, 010507, Romania
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Bucharest, 011053, Romania
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Bucharest, 031141, Romania
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Bucharest, 060044, Romania
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Bucharest, 22328, Romania
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Cluj-Napoca, 400349, Romania
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Iași, 700515, Romania
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Oradea, 410001, Romania
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Oradea, 410032, Romania
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Oradea, 410469, Romania
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Oradea, 410562, Romania
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Ploieşti, 100179, Romania
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Timișoara, 300723, Romania
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Timișoara, 300736, Romania
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Belgrade, 11000, Serbia
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Belgrade, 11070, Serbia
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Belgrade, 11080, Serbia
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Kragujevac, 34000, Serbia
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Kruševac, 37000, Serbia
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Niš, 18000, Serbia
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Pančevo, 26101, Serbia
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Anyang-si, 14068, South Korea
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Busan, 49241, South Korea
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Cheonan-si, 31151, South Korea
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Daejeon, 34943, South Korea
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Goyang-si, 10380, South Korea
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Guri-si, 11923, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 06591, South Korea
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Badajoz, 06080, Spain
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Barcelona, 08035, Spain
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Barcelona, 08036, Spain
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Burgos, 09006, Spain
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Córdoba, 14004, Spain
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Granada, 18014, Spain
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Madrid, 28041, Spain
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Majadahonda, 28222, Spain
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Málaga, 29010, Spain
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Pamplona, 31008, Spain
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Valencia, 46010, Spain
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Valencia, 46026, Spain
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Falun, 79182, Sweden
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Gothenburg, 41345, Sweden
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Karlstad, 651 85, Sweden
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Linköping, 581 85, Sweden
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Lund, 221 85, Sweden
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Örebro, 70185, Sweden
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Stockholm, 141 86, Sweden
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Stockholm, SE-18288, Sweden
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Uppsala, 75185, Sweden
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Vaxjo, 352 34, Sweden
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Changhua, 500, Taiwan
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Kaohsiung City, 833, Taiwan
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New Taipei City, 220, Taiwan
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Taichung, 402, Taiwan
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Taichung, 40447, Taiwan
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Taichung, 40705, Taiwan
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Taichung, 433004, Taiwan
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Tainan, 704, Taiwan
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Taipei, 10002, Taiwan
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Taipei, 110, Taiwan
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Taipei, 11696, Taiwan
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Taoyuan, 333, Taiwan
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Yung Kang City, 71044, Taiwan
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Bangkok, 10210, Thailand
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Bangkok, 10220, Thailand
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Bangkok, 10300, Thailand
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Bangkok, 10330, Thailand
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Bangkok, 10400, Thailand
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Bangkok, 10700, Thailand
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Banphaeo, 74120, Thailand
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Hat Yai, 90110, Thailand
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Khlong Luang, 12120, Thailand
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Muang, 50200, Thailand
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Phitsanulok, 65000, Thailand
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Phutthamonthon, 73170, Thailand
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Ratchaburi, 70000, Thailand
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Ubonratchathani, 34000, Thailand
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Ivano-Frankivsk, 76018, Ukraine
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Kyiv, 01601, Ukraine
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Kyiv, 02002, Ukraine
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Kyiv, 03037, Ukraine
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Kyiv, 03049, Ukraine
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Kyiv, 03057, Ukraine
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Kyiv, 04114, Ukraine
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Kyiv, 04210, Ukraine
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Lviv, 79016, Ukraine
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Vinnytsia, 21001, Ukraine
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Vinnytsia, 21029, Ukraine
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Aberdeen, AB25 2ZN, United Kingdom
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Cardiff, CF14 4XW, United Kingdom
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Corby, NN18 9EZ, United Kingdom
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Coventry, CV3 4FJ, United Kingdom
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Dundee, DD1 9SY, United Kingdom
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Glasgow, G51 4TF, United Kingdom
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Liverpool, L9 7AL, United Kingdom
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London, EC1M 6BQ, United Kingdom
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London, SE5 9RS, United Kingdom
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Metropolitan Borough of Wirral, CH48 5AA, United Kingdom
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Northwood, HA6 2RN, United Kingdom
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Nottingham, NG7 2QW, United Kingdom
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Portsmouth, PO6 3LY, United Kingdom
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Shipley, BD18 3SA, United Kingdom
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Swansea, SN6 6NL, United Kingdom
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Thetford, IP24 1JD, United Kingdom
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York, YO21 8HE, United Kingdom
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Da Nang, 55000, Vietnam
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Haiphong, 180000, Vietnam
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Hanoi, 100000, Vietnam
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Hanoi, 10000, Vietnam
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Hà Nội, 100000, Vietnam
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Ho Chi Minh City, 7000000, Vietnam
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Ho Chi Minh City, 700000, Vietnam
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Ho Chi Minh City, 70000, Vietnam
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Hochiminh City, 700000, Vietnam
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Hồ Chí Minh, 700000, Vietnam

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