Triple threat: radiation and immunotherapy before chemotherapy may boost breast cancer response
NCT ID NCT07188246
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial is testing whether giving a short course of radiation (SBRT) and two injections of the immunotherapy drug pembrolizumab (Keytruda) before standard chemotherapy can improve outcomes for people with stage 2 or 3 breast cancer. The study aims to see if this combination can prime the immune system to better attack the tumor, leading to a higher rate of complete cancer disappearance at the time of surgery. About 40 participants with high-risk breast cancer will be enrolled.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Pembrolizumab (Keytruda) and stereotactic body radiation therapy (SBRT)
What this could lead to
If successful, this approach could improve the chance of eliminating all cancer before surgery, potentially reducing recurrence risk.
What could go wrong
This is a small, early-phase trial (40 people) with no control group. The added radiation and immunotherapy may cause side effects like skin toxicity, and the benefit over standard chemotherapy alone is not yet proven.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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St. Joseph's Health Care London
NOT_YET_RECRUITINGLondon, Ontario, N6A 4V2, Canada
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St. Joseph's Health Care London
RECRUITINGLondon, Ontario, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••