BREAST CANCER INVASIVE

This phase 2 trial is testing whether giving a short course of radiation (SBRT) and two injections of the immunotherapy drug pembrolizumab (Keytruda) before standard chemotherapy can improve outcomes for people with stage 2 or 3 breast cancer. The study aims to see if this combin…

This study tests a special scanner that helps surgeons see if any cancer cells are left behind during breast-conserving surgery. The goal is to remove all cancer in one go and avoid a second operation. About 100 women with invasive or in-situ breast cancer will take part. The sca…

This Phase 3 trial is testing whether extending treatment with the drug pyrotinib (either continuously or in cycles) can help prevent HER2-positive breast cancer from returning. About 488 adults who have already completed initial therapy will be randomly assigned to one of two ex…

This study is testing a new 3D automated ultrasound system called ATUSA to see how well it can image suspicious breast lesions. Up to 800 women with suspicious findings on standard imaging will get an ATUSA scan before their biopsy. The goal is to collect images and compare them …

This phase 2 trial tests whether drinking tart cherry juice can prevent nerve damage (neuropathy) caused by the chemotherapy drug paclitaxel in breast and ovarian cancer patients. About 86 participants will be randomly assigned to receive either a high or low dose of the juice du…

This study is testing whether a low dose of the drug azacitidine, given before surgery, can increase immune cells (called tumor-infiltrating lymphocytes) in the tumors of people with high-risk early-stage breast cancer. About 40 participants will receive the drug for a short time…

This pilot study is looking at how the immune system responds in people with early-stage triple negative breast cancer who receive standard chemotherapy plus the immunotherapy drug pembrolizumab before surgery. The goal is to see if certain immune markers in the blood or tumor ti…

This study is testing a device called ScreenCell that counts circulating tumor cells (CTCs) in a blood sample from breast cancer patients. Researchers want to see if changes in CTC numbers over time can help track how the cancer is progressing. The study will include 93 women wit…

This study is testing whether educational videos and brochures can help Spanish-speaking Latinx patients with breast or prostate cancer better understand their radiation therapy and clinical trials. About 194 participants will watch videos or read brochures, then answer questions…