BREAST CANCER STAGE II

This study tests a device called TheraBionic P1 that uses radio waves to target cancer cells. It is given to people with early-stage, hormone-positive, HER2-negative breast cancer before their surgery. The goal is to see if the device can reduce the number of cancer cells left in…

This study tests several new drug combinations containing FWD1802 in people with a common type of advanced breast cancer (ER-positive/HER2-negative) that cannot be removed by surgery or has spread. The study has two parts: first, finding the safest dose (Phase 1), and then checki…

This study is for people with stage 2 or 3 breast cancer. It tests whether giving a special type of radiation (SBRT) and an immunotherapy drug (pembrolizumab) directly into the tumor before standard chemotherapy can help shrink the cancer more effectively. The goal is to see if t…

This study tests whether drinking tart cherry juice can help prevent nerve damage (neuropathy) caused by the chemotherapy drug paclitaxel in people with breast or ovarian cancer. About 86 participants will be randomly assigned to take either a high or low dose of the juice daily …

This study tests whether combining the drug memantine with a structured exercise program can improve memory and thinking problems (often called 'chemo brain') in women undergoing chemotherapy for early-stage breast cancer. About 90 participants will be split into three groups: on…

This study tests whether eating all meals within an 8-hour window each day can improve how well cancer treatments work and reduce side effects. Researchers will enroll 100 Alaska Native and American Indian adults with rectal or breast cancer. Participants will follow this eating …

This study tests an 8-week virtual rehabilitation program (CaRE@Home) for adults who have finished treatment for breast, colorectal, head and neck cancer, or lymphoma. The goal is to see if the program reduces disability and improves physical function, anxiety, and quality of lif…

This study looks at how the immune system responds in people with early-stage triple negative breast cancer who are receiving standard chemotherapy combined with immunotherapy (pembrolizumab). Researchers will measure certain immune markers in blood and tissue samples to see if t…

This study looks at how young women (ages 18-44) newly diagnosed with early-stage breast cancer decide on surgery. Researchers are testing a web-based tool called CONSYDER that provides helpful information and improves talks with surgeons. About 800 participants will fill out sur…

This study compares three types of remote medical interpreting (simultaneous, consecutive, and video) to see which one leads to fewer mistakes when Spanish- and Mandarin-speaking breast cancer patients talk with their English-speaking doctors. About 700 patients with stage II or …

This study is developing and testing a decision aid tool for women diagnosed with early-stage breast cancer. The tool is designed to help them make informed choices about their treatment. Researchers will compare how well the tool works in a group of 180 women who use it versus t…

This study is for people with early-stage breast cancer (Stage I-III) who will receive hormone therapy before surgery. The goal is to see how the cancer responds to this therapy and to find ways to predict that response. Participants will take hormone therapy as part of their reg…