LOCALLY ADVANCED BREAST CANCER
Clinical trials for LOCALLY ADVANCED BREAST CANCER explained in plain language.
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New drug cocktail shows promise for BRCA breast cancer patients
Disease control CompletedThis early-phase trial tested a combination of three drugs (olaparib, palbociclib, and fulvestrant) in 9 adults with BRCA-mutated, hormone receptor-positive, HER2-negative breast cancer that had spread or could not be removed. The main goal was to see if the combination was safe …
Matched conditions: LOCALLY ADVANCED BREAST CANCER
Phase: PHASE1 • Sponsor: Abramson Cancer Center at Penn Medicine • Aim: Disease control
Last updated May 17, 2026 03:09 UTC
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New drug combo shows promise for Hard-to-Treat breast cancer
Disease control CompletedThis study tested a new combination of two drugs, samuraciclib and elacestrant, in 49 adults with a type of advanced breast cancer (HR+/HER2-). The goal was to find the right dose and see if the combination is safe and can slow cancer growth. Participants had already tried other …
Matched conditions: LOCALLY ADVANCED BREAST CANCER
Phase: PHASE1, PHASE2 • Sponsor: Carrick Therapeutics Limited • Aim: Disease control
Last updated May 15, 2026 11:54 UTC
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New combo shows promise against tough breast cancer
Disease control CompletedThis study tested whether adding the experimental drug samuraciclib to the standard hormone therapy fulvestrant works better than fulvestrant alone. It involved 60 adults with a common type of advanced breast cancer (HR+/HER2-) that had worsened after prior treatment. The goal wa…
Matched conditions: LOCALLY ADVANCED BREAST CANCER
Phase: PHASE2 • Sponsor: Carrick Therapeutics Limited • Aim: Disease control
Last updated May 14, 2026 12:03 UTC
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New antibody drug shows promise against metastatic breast cancer
Disease control CompletedThis study tested an experimental drug called U3-1402 (patritumab deruxtecan) in 121 people with advanced or metastatic breast cancer. The goal was to see if the drug could shrink tumors and how safe it was. Participants received the drug intravenously, and researchers measured r…
Matched conditions: LOCALLY ADVANCED BREAST CANCER
Phase: PHASE2 • Sponsor: SCRI Development Innovations, LLC • Aim: Disease control
Last updated May 13, 2026 16:02 UTC
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Home infusion preferred by breast cancer patients in new study
Symptom relief CompletedThis study looked at whether people with HER2-positive breast cancer prefer getting their medication at home versus in the hospital. About 346 participants received a combination of two drugs (pertuzumab and trastuzumab) as a shot under the skin. The main goal was to see which se…
Matched conditions: LOCALLY ADVANCED BREAST CANCER
Phase: PHASE3 • Sponsor: Hoffmann-La Roche • Aim: Symptom relief
Last updated May 17, 2026 03:16 UTC