LOCALLY ADVANCED BREAST CANCER
Clinical trials for LOCALLY ADVANCED BREAST CANCER explained in plain language.
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New drug shrinks tumors in some breast cancer patients
Disease control CompletedThis phase 2 study tested a drug called patritumab deruxtecan in 121 people with advanced or metastatic breast cancer. The drug is an antibody-drug conjugate designed to deliver chemotherapy directly to cancer cells. The main goal was to see how many patients had their tumors shr…
Matched conditions: LOCALLY ADVANCED BREAST CANCER
Phase: PHASE2 • Sponsor: SCRI Development Innovations, LLC • Aim: Disease control
Last updated Jun 27, 2026 12:36 UTC
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New drug combo shows promise for tough breast cancer
Disease control CompletedThis study tested a new two-drug combination (samuraciclib and elacestrant) in 49 adults with a common type of advanced breast cancer (HR+/HER2-). The goal was to find a safe dose and see if it can slow the cancer's growth. Participants had already tried other treatments and thei…
Matched conditions: LOCALLY ADVANCED BREAST CANCER
Phase: PHASE1, PHASE2 • Sponsor: Carrick Therapeutics Limited • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
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Triple threat: new drug cocktail targets BRCA breast cancer
Disease control CompletedThis early-phase trial tested a combination of three drugs—olaparib, palbociclib, and fulvestrant—in 9 people with BRCA-mutated, hormone-positive, HER2-negative metastatic breast cancer. The main goal was to see if the combination is safe. Researchers also looked at how long the …
Matched conditions: LOCALLY ADVANCED BREAST CANCER
Phase: PHASE1 • Sponsor: Abramson Cancer Center at Penn Medicine • Aim: Disease control
Last updated Jun 27, 2026 08:09 UTC
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New combo shows promise against Hard-to-Treat breast cancer
Disease control CompletedThis study tested whether adding the experimental drug samuraciclib to standard hormone therapy (fulvestrant) works better than fulvestrant alone for people with advanced HR+/HER2- breast cancer. The trial enrolled 60 adults whose cancer had worsened despite prior treatment. Rese…
Matched conditions: LOCALLY ADVANCED BREAST CANCER
Phase: PHASE2 • Sponsor: Carrick Therapeutics Limited • Aim: Disease control
Last updated Jun 27, 2026 08:07 UTC
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New ultrasound technique may predict chemo response in breast cancer
Diagnosis CompletedThis study tested whether a special 3D ultrasound technique, called shear wave elastography, can predict how well breast cancer responds to chemotherapy before surgery. Researchers measured tumor stiffness in 140 women with locally advanced breast cancer at several points during …
Matched conditions: LOCALLY ADVANCED BREAST CANCER
Phase: NA • Sponsor: Institut Curie • Aim: Diagnosis
Last updated Jun 27, 2026 07:59 UTC
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Home sweet home? breast cancer patients may prefer At-Home drug infusions
Symptom relief CompletedThis study looked at whether people with early or locally advanced HER2-positive breast cancer prefer receiving their medication (a combination of pertuzumab and trastuzumab) at home versus in the hospital. About 346 participants were randomly assigned to receive the drug at home…
Matched conditions: LOCALLY ADVANCED BREAST CANCER
Phase: PHASE3 • Sponsor: Hoffmann-La Roche • Aim: Symptom relief
Last updated Jun 27, 2026 09:03 UTC