Could Pre-Surgery radiation make inoperable breast tumors removable?

NCT ID NCT05479409

Recruiting now Disease control Sponsor: Fudan University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether giving radiation therapy before surgery can shrink advanced breast tumors that didn't respond well to chemotherapy, making them operable. Researchers are also testing if a dietary supplement called beta-alanine and a special type of radiation (lattice radiotherapy) can boost the treatment's effect. The trial involves 70 participants with locally advanced breast cancer and aims to find better ways to control the disease and predict who will respond best.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: radiation therapy, beta-alanine dietary supplement, and spatially fractionated radiotherapy
What this could lead to: If successful, this approach could help shrink inoperable breast tumors enough for surgery and improve long-term control of the disease.
What could go wrong: This is a small, early-phase trial with only 70 participants, so results may not apply broadly. Radiation side effects are possible, and the added benefit of beta-alanine or lattice radiotherapy is unproven.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST NEOPLASMS

Contacts and locations

Locations

Fudan University Shanghai Cancer Center
RECRUITING

Shanghai, Shanghai Municipality, 200032, China

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