Could Pre-Surgery radiation make inoperable breast tumors removable?
NCT ID NCT05479409
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is testing whether giving radiation therapy before surgery can shrink advanced breast tumors that didn't respond well to chemotherapy, making them operable. Researchers are also testing if a dietary supplement called beta-alanine and a special type of radiation (lattice radiotherapy) can boost the treatment's effect. The trial involves 70 participants with locally advanced breast cancer and aims to find better ways to control the disease and predict who will respond best.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
radiation therapy, beta-alanine dietary supplement, and spatially fractionated radiotherapy
What this could lead to
If successful, this approach could help shrink inoperable breast tumors enough for surgery and improve long-term control of the disease.
What could go wrong
This is a small, early-phase trial with only 70 participants, so results may not apply broadly. Radiation side effects are possible, and the added benefit of beta-alanine or lattice radiotherapy is unproven.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Fudan University Shanghai Cancer Center
RECRUITINGShanghai, Shanghai Municipality, 200032, China
Contact Email: •••••@•••••