INVASIVE BREAST CANCER

This study is testing whether a new type of radiation therapy guided by MRI is safe and works well for people with gastric, breast, or other cancers. About 70 adults will receive this treatment along with chemotherapy. The goal is to see if the MRI guidance helps doctors target t…

This study tests a drug called trastuzumab deruxtecan, which delivers chemotherapy directly to cancer cells with low levels of HER2, either alone or with anastrozole (a hormone blocker). The goal is to see if these treatments can eliminate all signs of cancer before surgery in pe…

This study is for people with advanced breast cancer (T3 or T4) who responded well to chemotherapy. Instead of the usual approach—mastectomy, then radiation, then delayed reconstruction—researchers are testing if giving radiation before surgery allows for immediate reconstruction…

This study looks at whether taking vitamin D supplements during standard chemotherapy can help shrink tumors more effectively in people with triple negative breast cancer who are low in vitamin D. About 50 participants will either receive vitamin D plus chemotherapy or just chemo…

This study tests a daily pill called (Z)-endoxifen, sometimes combined with a monthly shot (goserelin) that temporarily stops the ovaries from making estrogen. The goal is to see if this treatment can slow or stop the growth of estrogen-receptor-positive, HER2-negative breast can…

This study tests whether two drugs, trastuzumab deruxtecan and durvalumab, can safely shrink or eliminate tumors in people with stage III inflammatory breast cancer that has a protein called HER2. About 63 participants will receive the drugs before surgery. The main goal is to se…

This study tests a drug called sacituzumab govitecan, given before surgery, in people with localized triple-negative breast cancer. The goal is to see if it can eliminate all cancer in the breast and lymph nodes. Some participants may also receive pembrolizumab. The study involve…

This study tests whether drinking tart cherry juice can help prevent nerve damage (neuropathy) caused by the chemotherapy drug paclitaxel in people with breast or ovarian cancer. About 86 participants will be randomly assigned to take either a high or low dose of the juice daily …

This study is testing whether a type of whole-body MRI (called DWB-MRI) can spot breast cancer that has come back or spread to other parts of the body earlier than standard scans. The goal is to see if finding it early leads to better treatment and longer survival. The study invo…

This study takes small tumor samples from 240 women with invasive breast cancer who are about to receive chemotherapy before surgery. Researchers will grow these samples into mini-tumors (organoids) in the lab to study each cancer's unique features. The goal is to see if these or…

This study collects leftover tissue from standard breast cancer surgeries and a one-time blood sample from 200 adults with breast cancer or precancer. Researchers will analyze these samples to identify tumor markers and gene patterns. The goal is to learn more about breast cancer…