Could a few radiation sessions be enough for breast cancer?

NCT ID NCT07076485

Recruiting now Disease control Sponsor: M.D. Anderson Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether shorter courses of radiation therapy can work as well as standard treatment for people with breast cancer that has spread to lymph nodes. About 768 participants who have had surgery will receive either a very short (ultrahypofractionated) or moderately short radiation schedule. The goal is to see if these shorter treatments are safe and effective at preventing cancer from returning.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Radiation therapy (ultrahypofractionated or moderately hypofractionated)
What this could lead to: If successful, this could offer a shorter, more convenient radiation schedule for breast cancer patients, reducing treatment burden while maintaining effectiveness.
What could go wrong: This is a Phase 2 trial, so results are preliminary. Shorter radiation may not be as effective as standard schedules, and there is a risk of increased side effects or cancer recurrence.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm invasive breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER

Contacts and locations

Locations

Banner MD Anderson Northern Colorado
RECRUITING

Loveland, Colorado, 80538, United States
Cooper Hospital University Medical Center
RECRUITING

Voorhees Township, New Jersey, 08103, United States
The University of Texas M. D. Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
University of Texas Health Science Center at San Antonio
RECRUITING

San Antonio, Texas, 78229, United States

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