One-Time radiation during lumpectomy may simplify breast cancer treatment

NCT ID NCT04994067

Recruiting now Disease control Sponsor: Albert Einstein College of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This registry study is following 500 women with early-stage breast cancer who receive a single dose of radiation directly to the tumor site during surgery (IORT). The goal is to see how well this approach controls cancer locally and what side effects occur. Participants are women aged 45 and older with low-risk breast cancer who are candidates for breast-conserving surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Intra-operative radiation therapy (IORT) using the IntraBeam system
What this could lead to: If successful, this could confirm IORT as a safe and effective option for partial breast irradiation, reducing the need for multiple radiation sessions.
What could go wrong: This is an observational registry, not a controlled trial, so results may not prove cause and effect. Side effects like radiation toxicity are possible, and long-term outcomes are still being tracked.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm ductal breast carcinoma in situ invasive breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER

Contacts and locations

Locations

Montefiore Medical Center - Moses Campus
RECRUITING

The Bronx, New York, 10467-2490, United States

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