Can less radiation be just as effective for some breast cancers?

NCT ID NCT07469267

Recruiting now Disease control Sponsor: Fudan University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial is testing whether giving radiation only to the lower armpit lymph nodes works as well as giving radiation to a larger area of lymph nodes in breast cancer patients who have 1-2 positive sentinel nodes. The study plans to enroll 1608 women with early-stage breast cancer. The goal is to see if the smaller radiation field can prevent cancer from coming back while potentially causing fewer side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: radiation therapy
What this could lead to: If successful, this could show that a smaller radiation field is just as effective as full regional radiation, reducing side effects for many breast cancer patients.
What could go wrong: This is an ongoing phase 3 trial, so results are not yet known. It is possible that the smaller radiation field may lead to higher recurrence rates, and the study only includes a specific group of patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm invasive breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER RADIOTHERAPY

Contacts and locations

Locations

Cancer Hospital of Shandong First Medical University (Shandong Cancer Institute,Shandong Cancer Hospital)
NOT_YET_RECRUITING

Jinan, Shandong, China
Changde Hospital, Xiangya school of Medicine, Central South University (The first people's hospital of Changde city)
NOT_YET_RECRUITING

Changde, Hunan, China
Department of Chemoradiation Oncology, The Affiliated Lihuili Hospital of Ningbo University
NOT_YET_RECRUITING

Ningbo, Zhejiang, China
Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
NOT_YET_RECRUITING

Wuhan, Hubei, China
Department of Radiation and Medical Oncology, Affiliated Zhongshan Hospital of Dalian University
NOT_YET_RECRUITING

Dalian, Liaoning, China
Department of Radiation and Medical Oncology，Zhongnan Hospital of Wuhan University
NOT_YET_RECRUITING

Wuhan, Hubei, China
Fudan University Shanghai Cancer Center
RECRUITING

Shanghai, Shanghai Municipality, China
Harbin Medical University Cancer Hospital
NOT_YET_RECRUITING

Harbin, Heilongjiang, China
Hunan cancer hospital/The affiliated cancer hospital of xiangya school of medicine,Central South university
NOT_YET_RECRUITING

Changsha, Hunan, China
Oncology Department, Guizhou Provincial People's Hospital
NOT_YET_RECRUITING

Guiyang, Guizhou, China
Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, China
The Fourth Hospital of Hebei Medical University
NOT_YET_RECRUITING

Shijiazhuang, Hebei, China
The Second Affiliated Hospital of Zhejiang University
NOT_YET_RECRUITING

Hangzhou, Zhejiang, China
Tianjin Medical University Cancer Institute and Hospital
NOT_YET_RECRUITING

Tianjin, Tianjin Municipality, China
Zhejiang Cancer Hospital
NOT_YET_RECRUITING

Hangzhou, Zhejiang, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.