RADIOTHERAPY

This study tests two different radiation schedules (short-course vs long-course) combined with an immunotherapy drug (Adebrelimab) and chemotherapy before surgery for people with locally advanced rectal cancer. The goal is to see which approach better shrinks or eliminates the tu…

This study tests a new approach for people with a common type of high-risk colon cancer that doesn't respond well to immunotherapy alone. The treatment combines a special type of radiation that spares lymph nodes, followed by chemotherapy and an immunotherapy drug. The goal is to…

This study tests whether a low dose of radiation to the gut can help the immune system fight cancer again in people with advanced solid tumors (like lung or esophageal cancer) that no longer respond to standard immunotherapy. About 48 participants will receive one radiation sessi…

This study tests a new treatment plan for people with advanced liver cancer that has either spread to a few other spots or formed a blood clot in the main liver vein. The treatment combines chemotherapy directly into the liver artery, two immunotherapy drugs, and targeted radiati…

This study tests whether adding a new immunotherapy drug (iparomlimab and tuvonralimab) to standard chemoradiation can help control advanced head and neck cancer. About 27 adults with stage III-IVB disease will receive the combination. The goal is to see if it improves the chance…

This study tests whether a combination of chemotherapy and radiation before surgery (total neoadjuvant therapy) can help about half of rectal cancer patients achieve a complete response, allowing them to avoid surgery and preserve their rectum through a watch-and-wait strategy. T…

This study tests whether giving radiation to the chest area can prevent or delay symptoms like pain or breathing trouble in people with Stage IV non-small cell lung cancer that has spread. About 48 participants will receive this preventive radiation along with their usual cancer …

This study tests whether adding radiation therapy to a combination of chemotherapy and immunotherapy before surgery can improve outcomes for people with resectable stomach or gastroesophageal junction cancer. About 40 participants will be randomly assigned to receive either the s…

This study tests whether giving radiation only to the lower armpit lymph nodes works as well as radiating a larger area in breast cancer patients whose cancer has spread to 1 or 2 lymph nodes. About 1,600 women with early-stage breast cancer will be randomly assigned to one of tw…

This phase 3 trial tests whether adding immunotherapy (a PD-1 inhibitor) after standard chemoradiotherapy helps adults with locally advanced esophageal squamous cell cancer live longer without the disease getting worse. About 452 participants will be randomly assigned to receive …

This study compares a 1-week course of partial breast radiation to standard whole breast radiation in women with early-stage breast cancer. The goal is to see if the shorter treatment is just as effective at preventing cancer from coming back and causes fewer cosmetic side effect…

This study tests a special radiation method called lattice radiation therapy (LRT) combined with immunotherapy for people with advanced solid tumors that have not responded to standard treatments. The radiation creates high-dose spots inside the tumor to kill cancer cells while s…

This study tests whether adding low-dose radiation and an immunotherapy drug (cadonilimab) to standard chemotherapy can help people with advanced nasopharyngeal cancer live longer without the cancer coming back. About 380 adults aged 18-70 with newly diagnosed, advanced-stage dis…

This study tests whether adding a natural supplement (β-hydroxybutyrate) to a standard treatment plan can help shrink or eliminate rectal cancer before surgery. The plan includes short-course radiation, immunotherapy, and chemotherapy. The goal is to see if more patients achieve …

This study tests a combination of two drugs (fruquintinib and sintilimab) with or without radiation therapy for people with colorectal cancer that has spread to the liver and hasn't responded to two prior treatments. The goal is to see if this approach can control the cancer long…

This study tests whether giving a special type of radiation (ultra-fraction radiotherapy) before CAR-T cell therapy can safely improve outcomes for people with relapsed or refractory diffuse large B-cell lymphoma. About 20 adults whose cancer has not responded to at least two pri…

This study is for people with kidney cancer that got worse after immunotherapy. It tests a special type of radiotherapy (multimodal radiotherapy) to see if it can control the cancer better. About 35 participants will receive this treatment, and doctors will monitor tumor shrinkag…

This study tests whether adding immunotherapy to a precise type of radiation (sparing tumor-draining lymph nodes) plus chemotherapy can better control advanced esophageal cancer. About 432 adults with squamous cell carcinoma will receive either the triple combination or radiation…

This study looks at 90 people with cancer that has spread to the brain to find the best time to give radiation after surgery. Doctors will compare giving radiation before, during, or after the operation to see which approach best prevents the tumor from coming back. The goal is t…

This study looks at whether holding your breath deeply during breast cancer radiation can keep the heart safe from radiation damage. About 400 women with early-stage breast cancer will either use a special breathing device or breathe normally during treatment. The goal is to meas…

This study is for people with kidney cancer that has spread to a few places and is starting to grow again despite current treatment. Instead of switching to a new drug right away, doctors will use precise, high-dose radiation on the growing spots. The goal is to control those spo…

This study compares two types of radiation therapy for localized prostate cancer: a newer ultra-short course versus a standard shorter course, both combined with a precise internal radiation boost. Researchers want to see if the ultra-short approach causes fewer urinary and bowel…

This study looks at whether spending time with horses can improve quality of life and reduce anxiety in children and teens (ages 8 to 17) who are receiving radiation therapy for cancer. About 22 participants will take part in horse-assisted therapy sessions. Researchers will meas…

This study looks at whether a video call with a radiation therapist before starting radiotherapy helps breast cancer patients feel less scared and worried compared to a standard phone call. About 130 people will take part and fill out questionnaires at three points. The goal is t…

This study tests a method called bioelectrical impedance to monitor fluid retention (edema) in cancer patients. It includes 46 people: breast cancer patients with arm swelling after radiotherapy and hospitalized patients with leg swelling after chemotherapy. Participants will hav…

This study aims to find early signs in the brain that can predict if a glioblastoma patient will survive at least 6 months after starting bevacizumab. Researchers will use special MRI scans to measure certain chemicals in the tumor. The goal is to help doctors decide which patien…

This study is gathering information from 500 people with small cell lung cancer to learn how to personalize treatment using radiation and immunotherapy. Researchers will track how long patients live without their cancer growing and overall survival. The goal is to find the best t…

This study looks at whether testing for HPV after radiation treatment for cervical cancer can help find cancer that has come back. Researchers will collect samples from 120 patients before and up to two years after treatment. The goal is to see if HPV testing is better than curre…

This study looks at 150 people with radiation rectal injury to see if different types of the condition lead to different outcomes. Researchers will collect medical records, test results, and follow-up data without changing any treatments. The goal is to better understand the dise…

This study compares two types of educational videos for people about to start radiation therapy: one made with an AI avatar and another using standard slides with voiceover. About 136 patients will watch one of the videos and answer questions about their anxiety and understanding…

This study is for people with advanced gastroenteropancreatic neuroendocrine tumors (GEP-NETs) who are receiving a type of targeted radiation called PRRT. Researchers will use advanced PET-MRI scans and genetic tests to find early signs of whether the treatment is working. The go…

This study looks back at medical records of 350 people with cervical cancer that has come back or spread to only a few places. The goal is to see how well different treatments like radiation, surgery, or chemotherapy work. By understanding what helps these patients live longer, d…

This study monitors the nutritional health of 57 adults with head and neck cancer who are receiving radiation therapy. Researchers regularly check body composition, muscle strength, food intake, and quality of life to spot early signs of malnutrition. The goal is to better unders…