RADIOTHERAPY

This study compares two types of radiation therapy for women with early-stage breast cancer who have had a lumpectomy. One group receives radiation to the whole breast, the other only to the area where the cancer was removed. Both treatments are given once a day for about one wee…

This study tests whether adding a single, low dose of radiation to the small intestine can make a standard immunotherapy-plus-chemotherapy regimen work better for people with esophageal cancer that cannot be easily removed by surgery. About 43 adults with borderline resectable or…

This study tests whether a lower dose of short-course radiotherapy, combined with chemotherapy and two immune-boosting drugs, works as well as the standard radiation dose for locally advanced rectal cancer. About 122 adults will be randomly assigned to one of two radiation doses,…

This phase 3 trial tests whether adding an immunotherapy drug (HLX10) to standard chemotherapy and radiation before surgery improves outcomes for people with locally advanced rectal cancer. It compares short-course versus long-course radiation, both followed by immunotherapy and …

This study tests whether a combination of chemotherapy and radiation (total neoadjuvant therapy, or TNT) can shrink rectal tumors enough so that some patients can avoid surgery and instead be monitored closely. About 400 adults with early-stage rectal cancer will be randomly assi…

This phase 3 trial tests whether adding an immunotherapy drug (cadonilimab) and low-dose radiation to standard chemotherapy can improve outcomes for people with advanced nasopharyngeal cancer. About 380 participants will be randomly assigned to receive either the new combination …

This study tests a new treatment plan for people with advanced liver cancer that has spread to blood vessels or a few other spots. The plan combines chemotherapy directly into the liver, two immunotherapy drugs, a targeted therapy, and precise radiation. The goal is to see if thi…

This study tests whether adding radiotherapy to a drug combination (fruquintinib and sintilimab) can help control colorectal cancer that has spread to the liver and hasn't responded to two prior treatments. About 62 adults with a specific type of colorectal cancer (MSS/pMMR) will…

This phase 2 trial tests a new radiation technique called lattice radiation therapy (LRT) combined with immunotherapy in 30 people with advanced solid tumors that have not responded to standard treatments. LRT delivers high doses of radiation to small spots inside the tumor while…

This phase 2 trial is testing whether adding a dietary supplement called β-hydroxybutyrate to a standard treatment plan (short-course radiotherapy, immunotherapy, and chemotherapy) can improve outcomes for people with locally advanced rectal cancer. The study will enroll 25 adult…

This study tests whether adding immunotherapy (a drug that helps the immune system fight cancer) after standard chemotherapy and radiation can help people with advanced esophageal cancer live longer without the disease getting worse. About 452 adults with a specific type of esoph…

This study tests whether giving a special type of radiotherapy (ultra-fraction) before CAR-T cell therapy can safely improve outcomes for people with relapsed or refractory diffuse large B-cell lymphoma. About 20 adults who have failed at least two prior treatments will receive t…

This phase 3 trial is testing whether giving radiation only to the lower armpit lymph nodes works as well as giving radiation to a larger area of lymph nodes in breast cancer patients who have 1-2 positive sentinel nodes. The study plans to enroll 1608 women with early-stage brea…

This phase 2 trial tests whether adding two immunotherapy drugs (iparomlimab and tuvonralimab) to standard chemoradiotherapy can improve outcomes for people with locally advanced head and neck cancer. The study will enroll 27 participants and track how many remain cancer-free aft…

This study tests whether high-dose, precise radiation (stereotactic radiotherapy) can control a few growing kidney cancer spots while the rest of the disease is stable on current medication. About 77 people with metastatic kidney cancer whose tumors are progressing in only a few …

This study tests whether adding immunotherapy to a precise type of radiotherapy (sparing tumor-draining lymph nodes) and chemotherapy can help adults with advanced esophageal cancer live longer without the disease getting worse. About 432 participants will receive either the comb…

This phase II trial is testing whether a new approach—using targeted radiation that spares lymph nodes, followed by chemotherapy and an immunotherapy drug—can improve outcomes for patients with a specific type of high-risk colon cancer. The study will enroll 52 adults whose tumor…

This phase 2 trial compares two types of radiotherapy (short-course vs long-course) given alongside immunotherapy (Adebrelimab) and chemotherapy before surgery for locally advanced rectal cancer. The goal is to see which approach leads to a higher rate of complete tumor disappear…

This study tests whether a low dose of radiation to the small intestine can help the immune system fight cancers that have stopped responding to immunotherapy. About 48 adults with advanced lung, esophageal, or other solid tumors will receive one radiation session followed by con…

This phase 2 trial tests whether adding radiotherapy and two immunotherapy drugs (iparomlimab and tuvonralimab) to standard chemotherapy can improve outcomes for people with resectable stomach or gastroesophageal junction cancer. About 40 participants will be randomly assigned to…

This study tests whether a very short course of radiation (5 days) is as safe and effective as a longer course (2-3 weeks) for men with localized prostate cancer. All participants also receive a brachytherapy boost. The main goal is to compare side effects and quality of life ove…

This phase 2 trial is testing a combination of high-dose and low-dose radiotherapy, plus an immunotherapy drug, in 35 people with kidney cancer that got worse after prior immunotherapy. The goal is to see if this approach can control the disease and how safe it is. Participants w…

This study tests whether offering a palliative care consultation early—when patients with advanced cancer and bone metastases start radiotherapy—improves their satisfaction with care and quality of life. About 246 participants will be randomly assigned to receive either a tailore…

This trial compares two ways to educate breast cancer patients before radiotherapy: a standard phone call versus a videoconference with a radiation therapist. The goal is to see if seeing a face on screen reduces patients' fears and anxiety more than a voice on the phone. About 1…

This study tests whether spending time with horses can improve quality of life and reduce anxiety in children and teenagers (ages 8-17) who are receiving radiotherapy for cancer. Participants will take part in 10 horse-assisted therapy sessions. The goal is to see if this approac…

This study tests whether giving radiation to the chest early can prevent or delay symptoms like pain or trouble breathing in people with stage IV non-small cell lung cancer. About 48 participants will receive the radiation along with their usual cancer treatment. The goal is to s…

This study tests a new device that tracks a patient's breathing and position during radiation therapy for cancers in the chest or upper abdomen. The goal is to see if the system can help deliver treatment more accurately without needing backup methods. About 20 adults who require…

This study is gathering detailed information from 500 people with small cell lung cancer to learn how to tailor treatments like radiation and immunotherapy to each patient. The goal is to find the best timing and doses of radiotherapy to work with immunotherapy, improving outcome…

This study follows 57 head and neck cancer patients during radiotherapy to monitor their nutritional health. Researchers regularly check body composition, muscle strength, food intake, and quality of life using simple tests and questionnaires. The goal is to spot early signs of m…

This study explores whether a device that sends a tiny, safe electrical current through the body can better track fluid retention (edema) in cancer patients. Researchers will measure 46 people—breast cancer patients with arm swelling after radiation and others with leg swelling a…

This study tests whether an AI-generated avatar video helps radiotherapy patients understand their treatment and feel less anxious, compared to a standard slide-based video. About 136 patients will watch one of the two videos and answer questionnaires. The goal is to see if the A…

This study looks at whether testing for HPV DNA from a cervical swab or a blood sample can help find cervical cancer that has come back after radiotherapy. Researchers will follow 120 patients for two years after treatment, collecting samples at regular visits. The goal is to see…

This study looks back at medical records of 350 people with cervical cancer that has come back or spread to a few spots. The goal is to see how well treatments like radiation or surgery work, alone or with chemotherapy. Researchers want to find out which patients benefit most fro…

This study will follow 150 people with radiation rectal injury to see if different subtypes of the condition lead to different outcomes. Researchers will collect medical records, endoscopy images, and test results but will not change any treatments. The goal is to fill gaps in kn…

This study looks at whether certain brain chemicals can predict survival in people with glioblastoma (a fast-growing brain cancer) that has returned after standard treatment. Researchers will measure these chemicals with special scans 7 and 28 days after starting the drug bevaciz…

This study looks at whether holding a deep breath during breast cancer radiation therapy can lower the amount of radiation reaching the heart. Researchers will compare heart radiation doses in 400 women who use a special breathing device versus those who breathe normally. The goa…

This study is looking at people with a rare type of digestive system cancer called GEP-NET who are receiving a targeted radiation therapy (PRRT). Researchers will use special PET-MRI scans and artificial intelligence to find patterns that predict how well the treatment works. The…