RADIOTHERAPY

This study is testing if adding a type of immunotherapy drug (a PD-1 inhibitor) as a long-term maintenance treatment after standard chemoradiation helps people with locally advanced esophageal cancer live longer without their cancer getting worse. It will involve 452 adults and i…

This study is testing whether adding radiation therapy to the chest can prevent painful or difficult symptoms from developing in patients with advanced lung cancer that has spread. The radiation targets large tumors or tumors near sensitive areas in the chest. All participants wi…

This study is testing a combination of radiation, chemotherapy, and two immunotherapy drugs given before surgery for stomach cancer. The goal is to see if this approach can shrink or eliminate the tumor to make surgery more successful. Researchers will compare two different order…

This study is testing a new three-part treatment for people with high-risk colon cancer that doesn't typically respond well to immunotherapy alone. It combines a special type of radiation designed to spare lymph nodes, followed by chemotherapy and an immunotherapy drug (PD-1 inhi…

This study is testing whether adding a new two-drug immunotherapy (iparomlimab and tuvonralimab) to standard radiation and chemotherapy can better control advanced head and neck cancer. It will involve 27 adults with newly diagnosed, locally advanced cancer who haven't had prior …

This study is testing a two-part treatment for a type of blood cancer called diffuse large B-cell lymphoma that has come back or hasn't responded to standard chemotherapy. First, patients receive a short, intense course of radiation therapy. Then, they receive a personalized cell…

This study is testing whether a very low dose of radiation to the intestines can help restart the effectiveness of immunotherapy drugs in people with advanced, spreading cancers that have stopped responding to those drugs. It will enroll 48 adults with cancers like lung or esopha…

This study is testing a special breathing technique to protect the heart during radiation treatment for breast cancer. It involves holding a deep breath while radiation is delivered, which moves the heart slightly away from the treatment area. Researchers are observing 400 patien…

This study is testing whether adding a specialized form of radiation therapy can help control advanced kidney cancer that has started growing again after initial immunotherapy treatments. It will involve about 35 patients whose cancer has spread to multiple sites. The main goal i…

This study is testing a strategy to help patients whose kidney cancer has started to spread to just a few new spots while their current medications are still controlling the rest. The goal is to use very precise, high-dose radiation to destroy these few new spots. Researchers hop…

This study compares two radiation approaches for women with early-stage breast cancer. It tests whether targeting just the tumor area for one week works as well as treating the whole breast at preventing cancer from returning, while also aiming for better cosmetic results. The tr…

This study is testing whether a more targeted radiation treatment is just as good as the standard, broader radiation at keeping breast cancer from coming back. It involves over 1,600 women with early-stage breast cancer who have had surgery and have a small amount of cancer in 1-…

This large Phase 3 trial is testing whether adding a new immunotherapy drug (cadonilimab) and low-dose radiation to standard chemotherapy and radiation works better for people with newly diagnosed, advanced nasopharyngeal cancer. The study will compare the new combination to the …

This study is testing if an ultra-short course of radiation is as safe and effective as a moderately short course for treating localized prostate cancer. It will involve about 205 men and combines internal radiation (brachytherapy) with external beam radiation. The main goal is t…

This study is testing if adding an immunotherapy drug to a new, more targeted form of radiation and standard chemotherapy works better for treating advanced esophageal cancer. Researchers will compare the new three-part combination to just the targeted radiation and chemotherapy …

This study is testing whether a shorter, more intense course of radiation is as good as a longer, standard course when both are combined with a new immunotherapy drug and chemotherapy. The goal is to shrink tumors before surgery in people with locally advanced rectal cancer that …

This study is testing whether HPV tests from cervical swabs and blood samples can help detect if cervical cancer returns after a patient finishes radiotherapy treatment. Researchers will follow 120 patients for two years after their treatment to see if these HPV tests can find ca…

This study explores whether horse-assisted therapy can help children and teenagers feel less anxious and improve their quality of life while they receive radiotherapy for cancer. Researchers will measure changes in anxiety and well-being in about 22 young patients aged 8 to 18. T…

This study aims to find early signs from brain scans that can predict whether patients with recurrent glioblastoma (an aggressive brain cancer) will survive at least 6 months while taking the drug bevacizumab (Avastin). Researchers will scan patients' brains shortly after startin…

This study aims to find better ways to predict which patients with advanced neuroendocrine tumors will benefit from a targeted radiation therapy. Researchers will use a special combined PET-MRI scan and artificial intelligence (AI) to analyze images from 80 patients before, durin…

This study aims to understand how different patterns of rectal injury from radiation therapy affect a patient's long-term recovery. Researchers will observe 150 patients over time, collecting medical information and test results without changing their treatment. The goal is to fi…

This study looks back at the medical records of about 350 people whose cervical cancer returned or spread to a few new sites. Researchers want to understand which combinations of treatments—like chemotherapy, radiation, or surgery—led to the best survival and quality of life. The…