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One-Week radiation after breast cancer surgery could be just as good, with better looks

NCT ID NCT05417516

Recruiting now Disease control Sponsor: Ontario Clinical Oncology Group (OCOG) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 08, 2026 · Updated 2 times

Summary

This study compares two types of radiation therapy for women with early-stage breast cancer who have had a lumpectomy. One group receives radiation to the whole breast, the other only to the area where the cancer was removed. Both treatments are given once a day for about one week. The goal is to see if the shorter, partial treatment works as well at preventing cancer from coming back and causes fewer cosmetic changes to the breast. The study plans to enroll 910 women across multiple centers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
radiation therapy
What this could lead to
If successful, this could offer a shorter, more convenient radiation option after breast cancer surgery that preserves breast appearance.
What could go wrong
This is a large Phase 3 trial, but results are not yet available. Partial breast radiation may not control cancer as well as whole breast radiation in the long term.

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Conditions

The condition(s) this trial relates to.

breast neoplasm invasive breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST NEOPLASM FEMALE COSMETIC OUTCOME RADIOTHERAPY

Contacts and locations

Locations

  • Algoma District Cancer Program

    RECRUITING

    Sault Ste. Marie, Ontario, Canada

  • Arthur J. E. Child Comprehensive Cancer Centre-Clinical Research Unit

    RECRUITING

    Calgary, Alberta, Canada

  • BCCA-Vancouver Island Cancer Centre

    NOT_YET_RECRUITING

    Victoria, British Columbia, Canada

  • CHUM - Centre Hospitalier de L'Université de Montréal

    RECRUITING

    Montreal, Quebec, H2L 4M1, Canada

  • CHUQ-Pavillon Hotel-Dieu de Quebec

    RECRUITING

    Québec, Quebec, Canada

  • CHUS-Hopital Fleurimont

    RECRUITING

    Sherbrooke, Quebec, J1H5N4, Canada

  • CSSS Champlain - Charles LeMoyne

    RECRUITING

    Greenfield Park, Quebec, Canada

  • Centre Intégré Universitaire de Santé et de Services Sociaux de la Mauricie-Centre-du-Québec (CIUSSS MCQ)

    RECRUITING

    Trois-Rivières, Quebec, G8Z 3R9, Canada

  • GenesisCare Bedford Park

    RECRUITING

    Bedford Park, South Australia, 5042, Australia

  • GenesisCare Bundaberg

    RECRUITING

    Bundaberg, Queensland, 4670, Australia

  • GenesisCare Darlinghurst

    RECRUITING

    Darlinghurst, New South Wales, 2010, Australia

  • GenesisCare Fiona Stanley Hospital

    RECRUITING

    Murdoch, Western Austrailia, 6150, Australia

  • GenesisCare Hervey Bay

    RECRUITING

    Urraween, Queensland, 4655, Australia

  • GenesisCare Hollywood

    RECRUITING

    Nedlands, Western Australia, 6009, Australia

  • GenesisCare Hurstville

    RECRUITING

    Hurstville, New South Wales, 2220, Australia

  • GenesisCare Mater Hospital

    RECRUITING

    North Sydney, New South Wales, 2060, Australia

  • GenesisCare Southport

    RECRUITING

    Southport, Queensland, 4215, Australia

  • GenesisCare St Andrew's

    RECRUITING

    Adelaide, South Australia, 5000, Australia

  • GenesisCare Tugun

    RECRUITING

    Tugun, Queensland, 4224, Australia

  • GenesisCare Wembley

    RECRUITING

    Wembley, Washington, 6014, Australia

  • Juravinski Cancer Centre

    RECRUITING

    Hamilton, Ontario, Canada

  • London Regional Cancer Centre

    RECRUITING

    London, Ontario, Canada

  • McGill University Health Centre

    RECRUITING

    Montreal, Quebec, Canada

  • Princess Margaret Hospital

    RECRUITING

    Toronto, Ontario, Canada

  • QEII HSC - Nova Scotia Cancer Centre

    RECRUITING

    Halifax, Nova Scotia, Canada

  • Royal Victoria Regional Health Centre

    RECRUITING

    Barrie, Ontario, Canada

  • Saskatoon Cancer Centre

    RECRUITING

    Saskatoon, Saskatchewan, S7N 4H4, Canada

  • Stronach (Southlake) Regional Health Centre

    RECRUITING

    Newmarket, Ontario, Canada

  • Toronto-Sunnybrook Health Sciences Centre - Odette Cancer Centre

    RECRUITING

    Toronto, Ontario, Canada

  • Windsor Regional Cancer Centre

    RECRUITING

    Windsor, Ontario, N8W2X3, Canada

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