Can a simple supplement soothe Radiation-Damaged rectums?

NCT ID NCT06776016

First seen Aug 07, 2026 ยท Last updated Aug 07, 2026

Summary

This phase 2 trial tests whether a dietary supplement called tributyrin can reduce rectal bleeding in people who developed chronic radiation proctitis after pelvic radiotherapy. Participants take the supplement orally for 12 weeks, and researchers will measure changes in bleeding severity and quality of life. The study aims to see if this simple, non-invasive approach can offer relief without the need for more aggressive treatments.

What this could mean

Our plain-language read of the trial. This is informational only โ€” not medical advice or a prediction.

Active substance
tributyrin, a dietary supplement that is a prodrug of butyrate
What this could lead to
If it works, this could offer a simple, non-invasive way to reduce rectal bleeding and improve quality of life for people who have had pelvic radiation for cancer.
What could go wrong
This is a small, early-phase study without a placebo group, so results may not be definitive. The supplement may not improve symptoms for everyone, and some people could experience side effects or allergic reactions.

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Conditions

The condition(s) this trial relates to.

Gastrointestinal Hemorrhage radiation proctitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Sixth Affiliated Hospital, Sun Yat-sen University

    RECRUITING

    Guangzhou, Guangdong, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.