Can a simple supplement soothe Radiation-Damaged rectums?
NCT ID NCT06776016
First seen Aug 07, 2026 ยท Last updated Aug 07, 2026
Summary
This phase 2 trial tests whether a dietary supplement called tributyrin can reduce rectal bleeding in people who developed chronic radiation proctitis after pelvic radiotherapy. Participants take the supplement orally for 12 weeks, and researchers will measure changes in bleeding severity and quality of life. The study aims to see if this simple, non-invasive approach can offer relief without the need for more aggressive treatments.
What this could mean
Our plain-language read of the trial. This is informational only โ not medical advice or a prediction.
- Active substance
- tributyrin, a dietary supplement that is a prodrug of butyrate
- What this could lead to
- If it works, this could offer a simple, non-invasive way to reduce rectal bleeding and improve quality of life for people who have had pelvic radiation for cancer.
- What could go wrong
- This is a small, early-phase study without a placebo group, so results may not be definitive. The supplement may not improve symptoms for everyone, and some people could experience side effects or allergic reactions.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Sixth Affiliated Hospital, Sun Yat-sen University
RECRUITINGGuangzhou, Guangdong, China
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Other studies related to the condition(s) this trial covers.
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