Two-Drug combo aims to wipe out rectal cancer before surgery
NCT ID NCT07686796
First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time
Summary
This trial investigates whether adding two targeted drugs—tafolecimab and sintilimab—to standard chemoradiation can improve outcomes for people with locally advanced rectal cancer that has not spread. Participants receive short-course radiation followed by chemotherapy plus immunotherapy, with or without the additional drug. The main goal is to see if the cancer completely disappears before surgery or during a watch-and-wait approach.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- tafolecimab and sintilimab
- What this could lead to
- If successful, this combination could significantly increase the chance of eliminating all cancer before surgery, potentially allowing some patients to avoid surgery altogether.
- What could go wrong
- This is an early-phase trial with a relatively small number of participants. Adding these drugs may increase side effects, and the benefit over standard treatment is not yet proven.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Guangdong Provincial People's Hospital
Guangzhou, Guangdong, 510080, China
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