Can adding radiation at the right time boost immunotherapy for aggressive lung cancer?
NCT ID NCT06768307
First seen Aug 17, 2026 · Last updated Aug 17, 2026
Summary
This study is exploring whether giving radiotherapy at the same time as immunotherapy and chemotherapy, versus giving it after, works better as a first treatment for extensive-stage small cell lung cancer. The trial will enroll about 60 adults with this advanced cancer. Participants will receive the immunotherapy drug adebrelimab alongside standard chemotherapy, with radiation either during the fourth cycle or later. The goal is to see which timing helps delay cancer progression and improve survival.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- adebrelimab (an immunotherapy drug) combined with chemotherapy and radiotherapy
- What this could lead to
- If successful, this could establish a more effective first-line treatment for extensive-stage small cell lung cancer, potentially improving how long patients live without the disease progressing.
- What could go wrong
- This is an early-phase exploratory study with a small number of participants, so results may not be definitive. Combining immunotherapy with radiation can increase side effects, and the benefit over current standard care is not yet proven.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Peking University Cancer Hospital and Institute
RECRUITINGBeijing, Beijing Municipality, 100142, China
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