CHEMOTHERAPY

This study tests whether adding a single, low dose of radiation to the small intestine can make a standard immunotherapy-plus-chemotherapy regimen work better for people with esophageal cancer that cannot be easily removed by surgery. About 43 adults with borderline resectable or…

This study tests whether a combination of chemotherapy and radiation (total neoadjuvant therapy, or TNT) can shrink rectal tumors enough so that some patients can avoid surgery and instead be monitored closely. About 400 adults with early-stage rectal cancer will be randomly assi…

This phase 3 trial tests whether adding an immunotherapy drug (cadonilimab) and low-dose radiation to standard chemotherapy can improve outcomes for people with advanced nasopharyngeal cancer. About 380 participants will be randomly assigned to receive either the new combination …

This study is for people with high-risk stage III colorectal cancer. It tests whether using a blood test (ctDNA) to guide treatment decisions can improve outcomes. Participants will receive either standard chemotherapy or chemotherapy plus bevacizumab, with regular blood monitori…

This study is for people with high-risk stage II colorectal cancer who have a positive blood test for tumor DNA one month after surgery. It tests whether using that blood test to choose stronger or different chemotherapy can help clear the tumor DNA and prevent the cancer from co…

This study tests whether using a blood test that detects tumor DNA can help doctors decide how long chemotherapy should last for people with certain types of colorectal cancer. About 340 adults with stage II or low-risk stage III colorectal cancer will be randomly assigned to sta…

This phase 2 trial is testing whether adding a dietary supplement called β-hydroxybutyrate to a standard treatment plan (short-course radiotherapy, immunotherapy, and chemotherapy) can improve outcomes for people with locally advanced rectal cancer. The study will enroll 25 adult…

This study is for people with advanced stomach cancer that has spread and who have already tried one type of treatment. It tests a combination of three drugs (ramucirumab, nal-IRI, and trifluridine/tipiracil) to see if they can shrink tumors and help patients live longer. The stu…

This study tests a new approach for people with advanced gastroesophageal junction cancer that cannot be removed with surgery right away. The treatment combines targeted radiation, immunotherapy, and chemotherapy to shrink the tumor enough for surgery. The goal is to see if this …

This study is for people with advanced non-small cell lung cancer (stage IIIB/C-IV) who cannot tolerate standard chemoradiation. It tests a treatment plan of platinum-based chemotherapy, followed by a special type of radiation and the immunotherapy drug Tislelizumab. The goal is …

This study compares two approaches for breast cancer patients who still have cancer in their sentinel lymph node after chemotherapy: removing the underarm lymph nodes (surgery) or treating them with radiation. The goal is to see if radiation can reduce the risk of arm swelling (l…

This study tests if a special type of acupuncture (on the tongue area) can reduce taste problems caused by chemotherapy in people with gynecologic cancers. 75 participants will be randomly assigned to real acupuncture, fake acupuncture, or standard dietary advice. The goal is to …

This study tests a program called MAEva, which combines mindfulness and acceptance therapy, to see if it helps improve quality of life for people treated for non-metastatic breast cancer. About 190 participants will be randomly assigned to either the MAEva program or a discussion…

This study tests whether combining electroacupuncture (needles with mild electric pulses) with self-acupressure (pressing specific points on the body) can improve quality of life for people with early-stage breast cancer undergoing chemotherapy. About 192 participants will be spl…

This study is testing whether a mobile app that combines daily symptom reports with Fitbit data can help cancer patients better manage side effects during chemotherapy. Fifty adults with solid tumors will use the app for 90 days, receiving tips for mild symptoms and alerts to con…

This study tests a nurse-led program to help cancer patients be more physically active while receiving chemotherapy. About 50 adults with cancer will take part. The program includes activity plans, safety checks, and support tools. The goal is to see if this approach is practical…

This study tests whether acupoint application (sticking herbal pastes on specific body points) can relieve constipation and qi deficiency in people with colorectal cancer who have had chemotherapy. About 106 adults will be randomly assigned to receive either the acupoint treatmen…

This study looks at how to better support adults aged 65 and older during chemotherapy. Researchers will use a frailty score to create personalized care plans and track how well participants handle treatment. The goal is to see if this approach improves resilience and reduces hos…

This study explores whether a device that sends a tiny, safe electrical current through the body can better track fluid retention (edema) in cancer patients. Researchers will measure 46 people—breast cancer patients with arm swelling after radiation and others with leg swelling a…

This study explores whether cancer patients can safely monitor their own blood counts at home during chemotherapy. About 265 participants from Denmark, Poland, and Germany will test a home monitoring device for several cycles. The goal is to reduce unnecessary hospital visits, lo…

This study looks back at medical records of 350 people with cervical cancer that has come back or spread to a few spots. The goal is to see how well treatments like radiation or surgery work, alone or with chemotherapy. Researchers want to find out which patients benefit most fro…

This study looks at whether certain brain chemicals can predict survival in people with glioblastoma (a fast-growing brain cancer) that has returned after standard treatment. Researchers will measure these chemicals with special scans 7 and 28 days after starting the drug bevaciz…