CHEMOTHERAPY

This study tests a new immunotherapy drug (QL1706) combined with chemotherapy and a special type of radiation (quad shot) in people with advanced non-small cell lung cancer that has not been treated before. The goal is to see if adding radiation improves tumor shrinkage and delay…

This study tests a new combination of drugs for people with advanced esophageal squamous cell carcinoma (a type of throat cancer). The three drugs include a targeted therapy (becotatug vedotin), an immunotherapy (tislelizumab), and standard chemotherapy. The goal is to see if thi…

This study tests whether adding a probiotic called Lactobacillus johnsonii to standard chemotherapy and immunotherapy can help control advanced lung, breast, or stomach cancers. About 156 adults aged 18-75 will be randomly assigned to receive either the probiotic or a placebo alo…

This study tests a drug called entinostat combined with standard chemotherapy for people with advanced bladder cancer that has gotten worse after initial treatment. The goal is to see if this combination can shrink tumors or slow the disease. About 29 adults with measurable tumor…

This study tests whether combining an immunotherapy drug (tislelizumab) with standard chemotherapy and a targeted artery treatment can shrink stage III lung cancer that cannot be removed by surgery. About 39 adults with newly diagnosed, unresectable non-small cell lung cancer wil…

This study tests whether a drug called sotagliflozin can prevent heart, muscle, and fat damage caused by a common type of chemotherapy (anthracycline) in people with newly diagnosed lymphoma. About 60 adults will receive either the drug or a placebo during their first round of ch…

This study tests if applying sesame oil, aloe vera gel, or nitroglycerin ointment to the skin can prevent phlebitis (vein inflammation) caused by chemotherapy. About 190 adults with breast or colon cancer receiving specific chemo drugs through a peripheral IV will be enrolled. Re…

This study tests whether a prehabilitation (prehab) exercise program can reduce 'chemo brain'—memory loss, forgetfulness, and brain fog—in older adults (60-85) with colorectal cancer before they start chemotherapy. Participants will be assigned to either the exercise program or u…

This study aims to understand how people getting chemotherapy at a clinic (without staying overnight) feel about the nursing care they receive. Researchers will interview 10 to 20 adults to learn what 'individualized care' means to them and how it affects their treatment experien…

This study looks at how platinum-based chemotherapy can cause permanent hearing loss in cancer patients, especially those from poorer backgrounds. Researchers will test hearing and thinking skills in 172 patients from North West England before and after treatment. The goal is to …

This study will observe how adults receiving chemotherapy use digital media and how skilled they are at finding and understanding health information online. Researchers will survey 80 patients to learn about their digital habits and eHealth literacy. The goal is to better underst…