CHEMOTHERAPY

This phase 2 trial tests whether combining the immunotherapy drug tislelizumab with standard chemotherapy and a targeted chemo-blocking procedure (BACE) can shrink advanced, inoperable stage III non-small cell lung cancer enough to allow surgery. About 39 participants will receiv…

This study tests a new combination of three drugs—becotatug vedotin, tislelizumab, and chemotherapy—for people with advanced esophageal squamous cell carcinoma (ESCC) who have not had prior treatment. The goal is to see if adding the targeted drug becotatug vedotin to standard im…

This study tests whether adding a special type of radiation (quad shot radiotherapy) to a new immunotherapy drug (QL1706) plus chemotherapy can better control advanced non-small cell lung cancer. About 104 people with stage IV lung cancer that has not been treated yet will take p…

This study tests a new combination of the drug entinostat plus standard chemotherapy for people with advanced bladder cancer that has spread or cannot be removed by surgery and has not responded to first-line treatment. About 29 participants will receive the combination to see if…

This study is testing whether adding a probiotic called Lactobacillus johnsonii to standard chemotherapy and immunotherapy can help control advanced lung, breast, or stomach cancers. About 156 adults aged 18-75 will be randomly assigned to receive either the probiotic or a placeb…

This study tests whether electroacupuncture (using mild electric pulses on needles) plus tiny thumbtack needles can prevent nerve damage caused by chemotherapy in people with early-stage cancer. About 278 patients with breast, stomach, bowel, lung, or ovarian cancer will receive …

This study tests whether electroacupuncture (acupuncture with mild electrical pulses) combined with tiny thumbtack needles can prevent peripheral neuropathy—numbness, tingling, or pain—caused by chemotherapy in people with advanced cancer. The trial enrolls adults with stage IV b…

This study tests whether a drug called sotagliflozin can prevent heart, muscle, and fat damage caused by a common type of chemotherapy (anthracycline) in people with newly diagnosed lymphoma. About 60 adults who are scheduled to receive high-dose anthracycline will take either th…

This study compares three topical treatments—sesame oil, aloe vera gel, and nitroglycerin ointment—against no treatment for preventing phlebitis (vein inflammation) caused by chemotherapy. Researchers will enroll 190 adults with breast or colon cancer receiving specific chemo dru…

This study tests whether using a virtual reality headset with guided imagery—like calming nature scenes and breathing exercises—can reduce pain, anxiety, and fatigue in women with breast cancer during chemotherapy. Participants are randomly assigned to either receive VR-guided im…

This study tests whether a prehabilitation (prehab) exercise program can reduce memory loss, forgetfulness, and brain fog caused by chemotherapy in older adults with colorectal cancer. Researchers will enroll 86 physically inactive people aged 60-85 who are about to start chemoth…

This study looks at how platinum-based chemotherapy can cause permanent hearing loss in cancer patients, and whether people from poorer backgrounds are more affected. Researchers will test hearing and thinking skills in 172 patients from North West England before and after treatm…

This study looks at how adults getting chemotherapy use digital media and how well they understand online health information. Researchers will survey 80 patients about their digital habits and health literacy. The goal is to learn more so doctors can better support patients in us…

This observational study will interview 10 to 20 adults receiving chemotherapy as outpatients at a Turkish hospital. Researchers want to understand how patients perceive nursing care that is tailored to their individual needs, values, and lifestyle. The goal is to identify what m…