Gut bacteria boost? new trial tests probiotic alongside cancer drugs

NCT ID NCT07191405

Not yet recruiting Disease control Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether adding a probiotic called Lactobacillus johnsonii to standard chemotherapy and immunotherapy can help control advanced lung, breast, or stomach cancers. About 156 adults aged 18-75 will be randomly assigned to receive either the probiotic or a placebo alongside their regular treatment. The main goal is to see if the probiotic extends the time before the cancer worsens.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Lactobacillus johnsonii (a probiotic bacteria)
What this could lead to: If it works, this could show that adding a specific probiotic to standard cancer treatment helps control tumor growth and improves how well the immune therapy works.
What could go wrong: This is an early-stage trial with only 156 participants, so results may not apply to everyone. The probiotic might not provide any additional benefit over standard treatment, and there is a risk of side effects from the combination therapy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

gastric adenocarcinoma gastroesophageal junction adenocarcinoma lung adenocarcinoma triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHEMOTHERAPY IMMUNOTHERAPY

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