Sixth Affiliated Hospital, Sun Yat-sen University

This study looks at whether a special liquid diet called exclusive enteral nutrition (EEN) can help adults with active Crohn's disease feel better and reduce inflammation. About 300 participants will use EEN as their main treatment for 12 weeks. Researchers will track remission r…

This study tests whether adding treatment for H. pylori infection to standard chemotherapy (oxaliplatin and S-1) before and after surgery can help shrink tumors more effectively in people with locally advanced stomach or gastroesophageal junction cancer. About 198 participants wi…

This study looks at whether people with a certain type of rectal cancer (dMMR/MSI-H) can safely avoid surgery if their tumor disappears after immunotherapy. Standard treatments like surgery or chemo can cause lasting side effects, including loss of bowel control or needing a perm…

This study tests whether adding an immunotherapy drug (PD-1 antibody) to standard chemoradiation can improve outcomes for people with newly diagnosed rectal squamous cell carcinoma that hasn't spread. About 20 participants will receive chemotherapy, radiation, and the immunothera…

This study is for adults with Crohn's disease who did not get enough help from the standard dose of a drug called ustekinumab. It compares two approaches: adding another drug (upadacitinib) to ustekinumab, versus increasing the dose of ustekinumab alone. The goal is to see which …

This study looks at whether adding a second drug (vedolizumab) to the standard drug upadacitinib works better than upadacitinib alone for people with moderate-to-severe ulcerative colitis. Researchers will review medical records from 150 adults across six hospitals in China to se…

This study tests a new approach for people with a common type of high-risk colon cancer that doesn't respond well to immunotherapy alone. The treatment combines a special type of radiation that spares lymph nodes, followed by chemotherapy and an immunotherapy drug. The goal is to…

This study is for people with a specific type of high-risk colon cancer that usually doesn't respond well to immunotherapy alone. The researchers are testing whether adding a very low dose of radiation to the standard chemotherapy and immunotherapy can help the immune system figh…

This study tests a high-precision radiation treatment called SBRT for people with rectal cancer that has returned after initial treatment and cannot be removed by surgery. The goal is to see if SBRT can stop the tumor from growing for at least a year and improve survival. About 4…

This study watches how well IL-23 inhibitors work for adults with active Crohn's disease in everyday medical practice. About 665 participants will get treatment chosen by their doctor and be checked at 12 and 52 weeks for symptom relief, healing, and side effects. The goal is to …

This study tests whether combining a precise type of radiation (SBRT) with an immunotherapy drug (PD-1 antibody) can help people whose rectal cancer has returned and cannot be surgically removed. About 31 adults aged 18-75 with a specific type of colorectal cancer will receive th…

This study tests whether adding a low-dose of upadacitinib to a standard TNF inhibitor works better than increasing the TNF inhibitor dose alone for people with moderate-to-severe Crohn's disease who aren't getting enough relief. About 312 adults will be randomly assigned to one …

This study tests a new way to treat moderate to severe ulcerative colitis by using two drugs in sequence. First, a fast-acting drug (upadacitinib) is given for 8 weeks to quickly bring the disease under control, then patients switch to a safer long-term drug (vedolizumab) to keep…

This study tests a PD-1 immunotherapy drug, given alone or with chemotherapy, before surgery for people who have two or more colorectal cancers at the same time. The goal is to shrink the tumors so surgery can be less extensive, possibly preserving more of the colon. About 17 par…

This study is testing an interleukin-23 (IL-23) antibody drug in 200 adults with moderate to severe Crohn's disease or ulcerative colitis. The goal is to see if the drug can put the disease into remission without needing steroids. Participants will receive the drug and be monitor…

This study tests whether giving anesthesia drugs in personalized, adjusted doses can lower the risk of dangerously low blood pressure in people aged 65 and older during laparoscopic abdominal surgery. The researchers will compare this tailored approach to standard fixed-dose meth…

This study tests whether a nerve block (superior hypogastric plexus block) can help people recover better after laparoscopic surgery for colorectal cancer. About 170 adults having this surgery will be randomly assigned to receive the nerve block or not. The main goal is to see if…

This study tests whether megestrol acetate, a drug that boosts appetite, can prevent weight loss in people with locally advanced colorectal cancer who are receiving chemotherapy before surgery. About 60 adults will be randomly assigned to get either megestrol acetate or a placebo…

This study compares two surgical techniques (Parks and Bacon) for ultra-low rectal cancer to see which one results in better anal function and quality of life one year after surgery. About 256 adults with rectal cancer will be randomly assigned to one of the two procedures. The g…

This study looks at whether additional chemotherapy is helpful for people with colorectal cancer who have already received chemotherapy or chemoradiotherapy before surgery and whose cancer was found to be at an early stage after surgery. The goal is to see if skipping extra chemo…

This study looks back at the medical records of 200 women with breast cancer to compare two types of breast-conserving surgery: one done with a robot and one done with an endoscope. The goal is to see which method leads to fewer complications, shorter operation times, and better-…

This study looks at 150 people with radiation rectal injury to see if different types of the condition lead to different outcomes. Researchers will collect medical records, test results, and follow-up data without changing any treatments. The goal is to better understand the dise…

This study looks at whether gut bacteria differ between people whose colorectal cancer has spread and those whose cancer hasn't. Researchers will collect tumor tissue, normal tissue, and stool samples from 300 participants aged 18-75. The goal is to find bacterial patterns that m…

This observational study aims to create a model that uses multiple biological data types to predict whether rectal cancer patients will have a complete response to pre-surgery treatment. About 106 adults with locally advanced rectal cancer will provide samples before, during, and…

This study aims to find out if taking metformin before surgery changes how likely patients are to feel sick or vomit after general anesthesia. Researchers will follow 909 adults who are already taking metformin for diabetes and compare them to those not on the drug. The goal is t…

This study tracks 5,000 cancer patients receiving chemotherapy or targeted drugs to detect heart-related side effects early. Researchers use regular heart tests and blood markers to build a system that predicts serious heart problems. The goal is to improve patient safety and qua…

This study is testing whether an artificial intelligence (AI) system can analyze MRI scans to predict how well rectal cancer responds to chemotherapy and radiation before surgery. About 1,700 adults with advanced rectal cancer will have their scans reviewed by the AI to see if it…

This study looks at whether a special type of MRI, called amide proton transfer-weighted imaging, can accurately predict if rectal cancer has completely disappeared after chemotherapy and radiation. Researchers will scan 320 people before surgery and compare the scan results to t…