Radiation boost may help immunotherapy work in tough colon cancers
NCT ID NCT07279077
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase II trial tests whether adding a special low-dose radiation therapy to standard chemotherapy and an immunotherapy drug can improve treatment for a type of colon cancer that usually doesn't respond well to immunotherapy alone. The study enrolls 38 adults with high-risk, locally advanced colon cancer. Participants receive four cycles of the combination therapy before surgery to remove the tumor. The main goal is to see if this approach leads to a complete disappearance of cancer cells in the removed tissue.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- low-dose radiotherapy, chemotherapy (CAPOX), and PD-1 inhibitor (immunotherapy)
- What this could lead to
- If successful, this combination could offer a more effective neoadjuvant treatment for a hard-to-treat colon cancer subtype, potentially increasing the chance of complete tumor disappearance before surgery.
- What could go wrong
- This is a small, early-phase trial (38 participants) with no control group. The approach is experimental, and the added radiotherapy may increase side effects without improving outcomes. Results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
The Sixth Affiliated Hospital of Sun Yat-sen University
RECRUITINGGuangzhou, Guangdong, 510655, China
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- Can radiation plus immunotherapy make colon tumors disappear before surgery?