COLON CANCER

This study compares two types of surgery for right colon cancer: laparoscopic (keyhole) and open surgery, both using a special technique called complete mesocolic excision (CME). About 114 adults aged 18-90 with early-stage right colon cancer will be randomly assigned to one of t…

This study tests a new drug called QL1706 given before surgery for people with a specific type of colon cancer (MSI-H/dMMR) that has not spread far. About 363 participants will receive either QL1706 or standard care. The goal is to see if QL1706 can eliminate more tumor tissue be…

This early-stage trial tests a new drug called MDX2001 in about 285 people with advanced solid tumors that have spread. The main goals are to check the drug's safety and see if it can shrink tumors. This is a first-in-human study, so researchers are also finding the best dose to …

This study is testing an experimental drug called CBI-1214 for people with advanced colorectal cancer that has stopped responding to standard treatments. The drug is designed to help the body's immune cells attack the cancer. The main goals are to check the drug's safety, find th…

This study tests a procedure called chemoembolization for people with non-small cell lung cancer or lung tumors that have spread from other cancers. Doctors inject chemotherapy directly into the artery feeding the tumor and then block that artery with tiny beads. This traps the c…

This early-stage trial tests a new drug called PHN-012 in people with advanced colon, pancreatic, or lung cancer that has stopped responding to standard treatments. The drug is an antibody-drug conjugate, designed to deliver a powerful cancer-killing agent directly to tumor cells…

This early-phase study tests an experimental drug called RSC-1255, given alone or with hydroxychloroquine, in people with advanced solid tumors (like lung, colon, pancreatic, or brain cancer) that have stopped responding to standard treatments. The main goals are to find a safe d…

This study looks at the best way to treat colon cancer that is blocking the bowel. It compares doing emergency surgery right away versus first placing a stent or creating a stoma (a bag on the belly) to relieve the blockage, followed by planned surgery later. The goal is to see w…

This study tests a less invasive surgery for people with early-stage colon cancer. Instead of removing a large piece of the colon, doctors will remove only the tumor and a few key lymph nodes using a special dye. The goal is to see if this smaller surgery works as well as the sta…

This study tests a new treatment for people with certain advanced cancers (like pancreatic, stomach, or colon cancer) that have a specific genetic change called KRAS G12V. The treatment involves taking a patient's own white blood cells, modifying them in a lab to better recognize…

This study tests a new approach for people with a high-risk type of colon cancer that doesn't usually respond well to immunotherapy alone. The treatment combines low-dose radiation (sparing the lymph nodes) with chemotherapy and an immunotherapy drug (PD-1 inhibitor) before surge…

This study compares a new, less invasive treatment called endoscopic full-thickness resection (eFTR) to standard surgery for early colon cancer. About 434 adults with small, early-stage colon tumors will be randomly assigned to one of the two treatments. The goal is to see if eFT…

This study tests whether giving chemotherapy before surgery (instead of only after) helps people with blocked colon cancer complete their full treatment plan. About 232 adults with stable tumors will be randomly assigned to standard care or the new approach. The goal is to shrink…

This study tests a mix of immunotherapy drugs (sintilimab, IBI310, lenvatinib) to see if they can make certain stomach or colon cancers disappear without needing surgery. It includes 34 adults whose cancers have a specific genetic feature (dMMR/MSI-H) and have not spread. The goa…

This study tests a new treatment called A2B395 for adults with advanced solid tumors like colorectal, lung, and breast cancer. The therapy uses specially designed immune cells to target and kill cancer cells while protecting healthy ones. The study has two parts: first finding a …

This study tests a new drug that delivers radiation directly to cancer cells with a specific marker (GRPR). It is for adults with advanced cancers of the prostate, breast, lung, colon, cervix, or brain that have come back or spread. The main goal is to find a safe dose and see if…

This early-stage study tests a new treatment using a patient's own immune cells, modified to target a protein called CEA found on certain cancer cells. It is for adults with advanced lung, stomach, colon, rectal, esophageal, or pancreatic cancer who have not responded to standard…

This study tests a new treatment using a patient's own immune cells, called CAR T cells, that are specially designed to target and kill solid tumor cells while leaving healthy cells unharmed. It is for adults with certain advanced cancers, including lung, colon, pancreatic, ovari…

This study tests whether giving immunotherapy before surgery can help doctors completely remove T4 colon cancer in people with a specific genetic feature (dMMR). About 18 adults with this type of cancer will receive the treatment and then have surgery. The goal is to see if the c…

This study tests giving chemotherapy and an immunotherapy drug before surgery for people with locally advanced colon cancer. The goal is to see if this approach can make the tumor disappear completely and improve long-term survival. About 56 participants will receive the treatmen…

This study tests a new way of giving three chemotherapy drugs (TAS-102, oxaliplatin, and irinotecan) along with bevacizumab to people with advanced colorectal cancer that has stopped responding to standard treatments. The goal is to see if this approach can control the cancer and…

This study tests a combination of two drugs (fruquintinib and FOLFIRI) in people with advanced colorectal cancer that has spread. It is for those who have already had one prior treatment. The goal is to see if this new combination can help control the cancer longer and with manag…

This study is testing a new blood test that uses lasers and artificial intelligence to find early signs of breast, colon, pancreatic, ovarian, and lung cancer. Researchers will collect blood samples from 1,400 people aged 45 and older who are suspected of having one of these canc…

This study is testing a new type of PET scan that uses special probes to highlight digestive system cancers, such as stomach, liver, colon, and pancreatic cancers. Researchers will enroll 400 adults to see how well this imaging method finds tumors and tracks their response to tre…

This study is testing a new type of PET scan that uses a special tracer called 18F-FAPI-74 to see if it can find colon cancer spread more accurately than current scans. 100 people with colon cancer, either at first diagnosis or with suspected return, will get this scan. The goal …

This study looks at whether the things people buy at stores—like pain relievers or digestive aids—could be early warning signs of cancer. Researchers will compare the shopping habits of 2900 people, some diagnosed with cancer and some not, to see if certain purchases happen more …

This study tests if a smartphone app can help people at high risk of cancer eat less ultra-processed foods and improve their overall diet. About 170 participants will either get the app plus nutrition education or just education alone. The goal is to see if the app helps them mak…

This study tests if wearing surgical gloves during oxaliplatin chemotherapy can prevent nerve damage in the hands. About 84 adults with advanced colon cancer will be randomly assigned to wear gloves or not during treatment. The goal is to see if this simple, low-cost method reduc…

This study tests whether taking omega-3 fish oil capsules and doing simple resistance exercises with elastic bands can help cancer patients maintain muscle mass and strength. It involves 288 adults with various cancers who are at risk of muscle wasting. The goal is to improve phy…

This study tests a special home recovery program for frail patients aged 65 and older after colon cancer surgery. The program includes a health check, diet advice, and exercise guidance at home. Researchers want to see if this extra support helps patients recover faster and feel …

This study offers a free 8- to 12-week exercise program for people who have or had cancer. Participants join online or in-person exercise classes twice a week, led by trained specialists. The goal is to help improve physical activity levels and reduce cancer-related symptoms like…

This study tests whether giving lidocaine or a high dose of dexamethasone during colon cancer surgery can help the immune system recover better afterward. About 100 adults having surgery for colon cancer will be randomly assigned to receive one of these drugs or a placebo. Resear…

This study tests a program that helps cancer survivors on immune checkpoint inhibitors better manage their symptoms and reduce psychological distress. About 400 adults with breast, colon, lung, skin, or rectal cancer who recently started immunotherapy will receive weekly symptom …

This study tests whether giving lidocaine (a numbing medicine) through a vein during colon cancer surgery can reduce pain, lower the need for strong painkillers (opioids), and help the bowel start working again sooner. About 100 adults having elective laparoscopic colon resection…

This study tests whether using virtual reality (VR) can reduce severe belly pain and improve quality of life in people with digestive tract cancers. 360 participants will be split into three groups: one using a skills-based VR program, one using distracting VR videos, and a contr…

This study tests whether brodalumab, a drug used for autoimmune diseases, can safely reduce side effects caused by cancer immunotherapy. About 11 adults with various cancers who have developed immune-related side effects will receive brodalumab. The goal is to see if it can lower…

This study looks at whether yoga and mindfulness can improve the social, emotional, and physical well-being of people who have survived lung, colon, or non-Hodgkin's lymphoma cancer. Researchers will also check if these practices affect inflammation and gene activity. About 100 a…

This study follows up with people who previously received a gene therapy or immunotherapy vaccine (using poxviral vectors) for cancers like prostate, liver, breast, colon, or lung cancer. No new treatment is given. Participants get annual health checks for 5 years, then yearly ph…

This study collects blood and other samples from adults with cancer to learn how certain immune cells change before and after treatment. No treatment is given as part of this study. Up to 1,750 participants will provide samples, which researchers will analyze to better understand…

This study looks at how a radiation treatment called Y90 works against liver tumors that started in the colon or rectum. Researchers will take small samples of the tumors after treatment to see how much damage the radiation caused. The goal is to learn how to make this treatment …

This study focuses on improving the quality of care for Black patients newly diagnosed with gastrointestinal cancer. It helps ensure patients get the right biomarker tests, offers assistance in joining other clinical trials, and provides educational materials to improve understan…

This study will analyze the genes of 25,000 adults who have cancer or are at risk for it. Researchers will use advanced testing to find genetic changes linked to cancer and track health records over time. The goal is to learn more about cancer biology and discover new ways to per…

This study is creating a large, long-term database of medical information and biological samples from people with many types of cancer, those at high risk, and healthy volunteers. Researchers will use this resource to study what causes cancer, how it progresses, and how to better…

This study looks at whether a digital app can help cancer patients get genetic testing directly from their oncologist, instead of visiting a separate genetics clinic. The goal is to see if this approach reduces patient distress and improves care. About 180 adults with breast, pro…

This study aims to collect blood samples (liquid biopsies) from 2,500 people with cancer or at high risk for cancer. The samples will be stored and used for future research to better understand how cancer grows and responds to treatment. No direct treatment is given; the goal is …

This study aims to improve how doctors determine the stage of colon cancer before surgery and decide who needs chemotherapy. Researchers will analyze tiny particles in the blood called exosomal microRNAs from 400 participants using machine learning. The goal is to create a more a…

This study looks at whether adding a geriatrician (a doctor who specializes in care for older adults) to cancer treatment can improve outcomes for people aged 70 and older with gastrointestinal cancers like stomach, colon, or pancreatic cancer. Researchers will test if an online …

This study looks at whether keeping the left colic artery intact during colon or rectal cancer surgery helps maintain better blood flow to the remaining colon. About 50 adults with colorectal or ovarian cancer will have their blood flow measured with and without clamping this art…

This study is testing whether a blood test that looks for tumor DNA (ctDNA) can find cancer returning earlier than standard scans. About 100 people with different solid tumors will give blood samples after treatment. The goal is to see if early detection can lead to better treatm…

This study looks at stool and saliva samples from 2,500 people with colorectal cancer to find patterns in bacteria and genetic material (microRNA) that could help diagnose the disease earlier or predict how it will progress. Researchers will track these patterns over time, from d…

This study looks at whether a special nutritional supplement (HMB and vitamin D) combined with a structured exercise program can improve muscle strength and recovery in adults after colon cancer surgery. About 120 participants will be randomly assigned to different combinations o…

This study looks at how the bacteria in your gut and what you eat might affect chemotherapy-related diarrhea in people with colon cancer. Researchers will collect stool samples and diet surveys from 11 participants to build a tool that predicts who will get diarrhea. The goal is …

This study tests a program called CARES that provides advocacy, resources, education, and support to rural cancer patients. The goal is to see if it helps them start and finish their cancer treatment faster. About 320 adults with solid tumors like lung, breast, or colon cancer wi…

This study follows 368 colorectal cancer survivors aged 25 to 65 to see how their quality of life changes 6, 12, and 24 months after treatment. Researchers will use questionnaires to measure physical, mental, and social well-being and look for late side effects linked to specific…

This study looks at how cancer and its treatments change taste and smell, and how that leads to poor nutrition. Researchers will follow 306 people newly diagnosed with mouth, throat, colon, or liver cancer. The goal is to better understand these sensory changes so doctors can spo…

This study looks at people who have a gene variant (called a secondary finding) that was discovered during genetic testing for another reason. Researchers want to understand how these variants affect health, how people respond to the news, and whether they follow medical advice. …

This study looks at whether a special stitch material (MonoPlus®) can lower the chance of leaks where the intestine is reconnected after colon cancer surgery. About 249 people having this surgery will be checked for leaks within 30 days. The goal is to see if this material works …

This study looks at whether cleaning the bowel before surgery for colon cancer reduces the chance of infection after the operation. About 74 patients will be randomly assigned to either receive or skip the bowel prep. The main goal is to see if there is a difference in surgical s…

This study aims to find the genetic causes of certain blood cancers like lymphoma, leukemia, and multiple myeloma by studying families where more than one person has the disease. Researchers will collect DNA and blood samples from up to 500 participants, including patients and th…

This study is looking at whether a special DNA test (called ctDNA) done on blood or stool samples can help doctors better manage patients with cancers of the digestive tract, such as pancreas, colon, or bile duct cancer. About 100 adults with these cancers will provide samples, a…