COLON CANCER

This study looked at whether starting chemotherapy 10 to 14 days after colon cancer surgery is safer and more effective than waiting the usual 2 weeks. About 300 adults with stage III colon cancer took part. The goal was to see if earlier treatment improves 3-year survival and lo…

This early-stage study tests a new drug, HBI-2438, in people with advanced cancers (like lung, colon, or pancreatic cancer) that have a specific genetic mutation called KRAS G12C. The main goals are to find the safest dose and understand how the drug moves through the body. About…

This study tests whether giving chemotherapy before surgery (instead of after) helps people with locally advanced colon cancer live longer without the cancer returning. About 708 adults aged 18 to 70 with non-spreading colon cancer are taking part. The goal is to see if early che…

This study tested an oral drug called selpercatinib in 857 people with advanced solid tumors that have a specific genetic change (RET). The goal was to find the best dose and see if the drug can shrink tumors. Participants had cancers like lung, thyroid, or colon that had stopped…

This study tests whether taking postbiotic supplements after colon cancer surgery can help restore healthy gut bacteria. About 30 adults scheduled for surgery will be randomly assigned to receive either the supplement or a placebo. The main goal is to see if the supplement improv…

This study compares two cold snare techniques for removing medium-to-large colon polyps during a colonoscopy. About 570 adults will be randomly assigned to either piecemeal resection or endoscopic mucosal resection. The goal is to see which method removes polyps more completely a…

This study tests whether the drug cemiplimab can control a specific type of colon cancer (dMMR) without needing surgery. About 50 adults with early-stage colon cancer that has not spread will receive the drug. The main goal is to see if the treatment is safe and effective at cont…

This early-phase study tests an experimental oral drug (GSK4418959) in adults with advanced solid tumors that have specific genetic changes (dMMR or MSI-H). The drug works by blocking a protein (WRN) that these tumors need to survive. The study aims to see if the drug, alone or w…

This early-stage trial tests a new drug called adagrasib combined with two existing cancer drugs (cetuximab and irinotecan) in people with advanced colorectal cancer that has a specific genetic change called KRAS G12C. The main goal is to find a safe dose and check for side effec…

This study looks at four different tools to help people who have had cancer improve their diet, physical activity, and weight. About 353 cancer survivors will use these tools to see if they can adopt healthier habits that may lower the chance of their cancer coming back. The stud…

This study compares giving 3 rounds of chemotherapy before surgery versus the standard approach of surgery followed by 8 rounds of chemo for people with locally advanced colon cancer. The goal is to see if the pre-surgery chemo works just as well and may allow some patients to sk…

This study looks at whether giving chemotherapy both before and after surgery (perioperative) is better than only after surgery for people with advanced colon cancer. About 738 participants will be randomly assigned to one of two groups. The goal is to see if the perioperative ap…

This study tests a combination of three drugs (entinostat, PDS01ADC, and bintrafusp alfa) in adults with advanced cancers linked to HPV or certain colon cancers that haven't responded to standard treatments. The goal is to find a safe dose and see if the combo can shrink tumors. …

This study tests a combination of two drugs, cabozantinib and nivolumab, in people with advanced colorectal cancer that has not responded to standard treatments. The goal is to see if this combination can stop or shrink the cancer for at least 16 weeks. About 48 adults with a spe…

This study tests a special PET scan that uses a radioactive antibody (64Cu-M5A) to find cancers that produce a protein called CEA. The goal is to see if this scan can detect tumors that standard methods might miss. About 20 adults with CEA-positive cancers (such as breast, colon,…

This study follows 150,000 adults in the U.S. who were prescribed the Cologuard stool test for colorectal cancer screening. Researchers want to see how many people get a follow-up colonoscopy after a positive result and how often cancer is found. The goal is to understand the rea…

This early-phase study tests whether a green tea extract called EGCG can help prevent colon cancer from returning after surgery. About 50 people who had their colon cancer removed will take EGCG or a placebo. Researchers will look for changes in DNA markers linked to cancer risk.

This study tests ways to help more people complete a colonoscopy after an abnormal stool-based colorectal cancer screening test. The researchers will use team-based best practices in clinics and a patient app with enhanced instructions and navigation. About 2,000 adults who speak…

This study looks at whether cryotherapy (cooling therapy) can help prevent nerve damage caused by the chemotherapy drug oxaliplatin in people with stage III colon cancer. About 40 participants will use cold packs on their hands and feet during treatment. The goal is to see if thi…

This study looks at whether health education from nurses can improve quality of life and reduce anxiety and depression in people who have had digestive surgery and now have an ostomy. About 70 adults with permanent or long-term ostomies will take part in workshops and follow-up s…

This study tests a new fluorescent clip that glows under special lights to help surgeons locate colon tumors during minimally invasive surgery. About 110 adults with colon cancer will be randomly assigned to get either the clip or a standard dye injection before surgery. The goal…

This study tests whether a 6-week online program based on Acceptance and Commitment Therapy (ACT) can help cancer survivors who have finished treatment feel less anxious and depressed. 32 survivors of breast, colon, or rectal cancer will be randomly assigned to either the online …

This study tests whether using a FitBit and a mobile app after surgery for stomach, liver, colon, or other GI cancers can help prevent patients from being readmitted to the hospital. About 107 adults who own a smartphone and are scheduled for surgery will be randomly assigned to …

This study compares two surgical methods for a rare type of colon cancer located at the splenic flexure. About 140 patients will be observed to see which surgery leads to faster recovery and fewer complications. The goal is to help surgeons choose the best approach for better out…

This study brings together cancer experts to agree on standard definitions for key measurements used in cancer clinical trials, such as how long patients live without their cancer getting worse. Currently, different trials define these measurements in different ways, making it ha…

This study looks at survival rates for people with cancers like melanoma, breast, colon, and lung cancer using data from Russian cancer registries. It includes 100,000 people of any age. The goal is to understand survival trends to help improve cancer care, not to test a new trea…

This study looks for new types of gene changes that might raise cancer risk. Researchers compare cancer patients with their healthy parents and family members to find gene changes that appear only in the patient. About 1,275 people with breast, colon, germ cell, neuroblastoma, re…

This pilot study aims to find better ways to detect if colon cancer is likely to spread to the liver. Researchers will test new imaging and lab tests on 51 people having surgery for colon cancer or benign colon growths. The goal is to improve early detection and guide treatment d…

This study looked at 193 people with stomach, appendix, or colon cancer who had surgery to remove tumors. Some also received heated chemotherapy directly in the abdomen during the operation. Researchers compared how quickly bowel movements returned and how long people stayed in t…

This study explores whether a special type of radiation planning can protect the ovaries of young women (ages 18-50) receiving pelvic radiation for cancers like uterine, rectal, or cervical cancer. Researchers will use scans to see if they can adjust the radiation beam to avoid t…

This study is testing a new genetic test (Gersom panel) in 4,000 people with breast, ovarian, or colorectal cancer. The goal is to see if the test can accurately find inherited genetic risks and tumor mutations that may guide treatment choices. Participants provide tissue samples…

This study looks at whether a website and a genetic family navigator can help more relatives of people with hereditary cancer get genetic testing. About 205 participants will use the online hub and work with a navigator to learn about their cancer risk. The goal is to see if this…

This study looks at how exercise might stop colorectal cancer from returning. Researchers will measure changes in blood markers and insulin resistance in 60 patients who have finished their cancer treatment. The goal is to understand the biological processes behind exercise's pot…

This study collects and analyzes DNA from over 21,000 cancer patients in New York City to look for genetic differences that might be linked to cancers like breast, colon, lung, and prostate. The goal is not to treat anyone directly, but to find patterns that could lead to new res…

This study looks at whether a special payment model helps doctors coordinate care better for people with breast, colon, or lung cancer getting chemotherapy. Researchers will compare costs, quality of care, and use of hospital services between two groups. The goal is to see if thi…

This study aimed to find out if certain genes that affect bleeding can cause a false positive result on a stool test used to screen for colon cancer. Researchers planned to compare genetic markers in people who had a high test result but a normal colonoscopy with those who had no…