New triple therapy targets Hard-to-Treat cancers
NCT ID NCT04708470
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a combination of three drugs—bintrafusp alfa, PDS01ADC, and entinostat—in adults with advanced HPV-related cancers (like cervical, anal, or throat cancer) or certain colon cancers that haven't responded to standard treatment. The goal is to find a safe dose and see if the combo can shrink tumors. Participants receive treatment for up to 2 years and are followed for safety and response.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- bintrafusp alfa, PDS01ADC, and entinostat
- What this could lead to
- If it works, this could offer a new treatment option for advanced HPV-related and certain colon cancers that are hard to treat.
- What could go wrong
- This is an early phase I/II trial with only 55 participants, so results may not apply to everyone. The drugs can cause side effects, and the combination may not shrink tumors as hoped.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States
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