HPV

This is a first-in-human safety study of PANHPVAX, a new experimental vaccine designed to prevent infections from many types of cancer-causing human papillomavirus (HPV). The trial will enroll 45 healthy volunteers to test increasing doses of the vaccine, with and without an immu…

This study is testing whether a much lower dose of radiation, combined with standard chemotherapy, can effectively control HPV-positive throat cancer while causing fewer side effects. It will involve 121 adults with this specific cancer type who have not had prior radiation to th…

This study is testing if a blood test that measures HPV DNA can help doctors decide which patients need radiation after throat cancer surgery. The goal is to safely reduce or delay radiation treatment for some patients, potentially lowering side effects. It is for adults with HPV…

This study is testing a new treatment approach for people with a specific type of head and neck cancer that is not linked to HPV. The goal is to see if a combination of a new immunotherapy drug (volrustomig) with two standard chemotherapy drugs can shrink tumors before patients r…

This study is testing whether adding two new, experimental drugs (HB-201 and HB-202) to standard chemotherapy can better shrink tumors in people with HPV16-positive throat cancer. The goal is to see if this stronger initial treatment allows doctors to safely use less radiation or…

This study is watching women with severe cervical precancer to see if the abnormal cells go away on their own. Researchers will closely monitor 300 women aged 18-40, checking them every four months instead of immediately doing surgery. The goal is to identify which patients are m…

This study is testing whether a dietary supplement called Papillex® can help improve abnormal cervical cells caused by HPV. Women aged 25-55 with early-stage cervical cell changes (CIN1 or CIN2) will take either the supplement or a placebo for 180 days. Researchers will check if …

This study is testing if an immunotherapy drug called balstilimab can clear the HPV virus from the blood of throat cancer patients who have finished their main treatment but still show signs of the virus. The goal is to see if clearing this leftover virus can help prevent the can…

This study is testing whether HPV tests from cervical swabs and blood samples can help detect if cervical cancer returns after a patient finishes radiotherapy treatment. Researchers will follow 120 patients for two years after their treatment to see if these HPV tests can find ca…

This study aims to see if people living with HIV can accurately test themselves for HPV, a virus linked to anal cancer, using a simple swab at home. It will compare the results of self-swabs to those taken by a healthcare professional to check if they match. The research also wan…

This study is testing whether a new at-home kit can accurately detect the HPV virus from menstrual blood. People who need a follow-up cervical exam after an abnormal Pap or HPV test will use a special pad during their period and mail it to a lab. Researchers will compare these ho…

This study is testing whether two different at-home HPV self-collection kits are a good alternative to a doctor's Pap smear for cervical cancer screening. It focuses on helping minority women aged 25-65 who have fallen behind on their screenings, often due to barriers like langua…

This study aims to prevent HPV-related cancers by increasing vaccination rates in children aged 9-17. It will test if allowing nurses to give the HPV vaccine without needing a separate doctor's order for each patient works better than just training doctors to recommend it. The tr…

This study is testing a mobile phone app called mSaada, designed to help community health volunteers in Kenya find and screen more women for cervical cancer. The goal is to see if the app helps more women get screened, understand their risk, and receive treatment if they test pos…

This study is testing if starting the HPV vaccine at age 9-10, instead of the recommended 11-12, leads more parents to get their children fully vaccinated. Researchers believe earlier timing might reduce parental hesitation and ensure protection before potential exposure to the v…

This study is testing whether two doses of the HPV vaccine work as well as the standard three doses for women living with HIV. The goal is to prevent HPV infection and the cervical cancer it can cause. Researchers will compare the immune response in women who get two shots versus…

This study is testing a new community-based approach to help more women get screened for cervical cancer. Community health workers will visit women in low-resource areas of Texas to offer at-home HPV test kits and support. The goal is to see if this method is practical and accept…

This study is testing whether a video game can help convince more teens and their parents to get the HPV vaccine, which prevents several types of cancer. Researchers will enroll 180 unvaccinated 11-14 year olds and their parents, with some playing the game and others receiving st…

This study aims to understand how different menstrual products—like tampons, menstrual cups, and pads—affect the natural balance of bacteria and the immune system in the vagina. Researchers will compare 300 women who primarily use one of these three products, collecting samples t…

This study aims to understand anal cancer risk in men who have sex with men (MSM) who take medication to prevent HIV. Researchers want to know how common precancerous changes are in this group and test different screening methods to detect them early. The study will also measure …

This study aims to understand how the community of bacteria in the gut and vagina might influence a woman's risk of getting an HPV infection and developing cervical problems. It will follow 400 women living with HIV in China, collecting samples to analyze their bacteria and track…

This study aims to find the best way for clinics to offer at-home HPV self-test kits to women who are behind on their cervical cancer screening. Researchers will work with health centers to create and test a program that mails kits to eligible women and offers them in clinics. Th…

This study aims to understand why some otherwise healthy people get extremely sick from common viruses like herpes, flu, or chickenpox. Researchers will examine 600 participants who have had severe, long-lasting, or hard-to-treat viral infections, along with some of their family …