HPV

This study looks at whether giving two doses of the HPV vaccine instead of three can protect women living with HIV just as well. Researchers will compare immune responses in 275 Canadian women aged 18-45 who have not been vaccinated before. If two doses work, it could make HPV va…

This early-phase trial tests a new vaccine called PANHPVAX in 45 healthy adults aged 18-45. The vaccine targets a part of the HPV virus (L2 antigen) to potentially protect against multiple HPV types. The main goal is to check safety and how well the body's immune system responds …

This study is testing whether a much lower dose of radiation (30 Gy) combined with standard chemotherapy can control HPV-positive throat cancer as well as the usual high dose (70 Gy). The goal is to reduce side effects from radiation while still keeping the cancer from coming bac…

This study is testing whether people with early-stage HPV-positive throat cancer can be treated with radiation alone at a lower dose, instead of the usual full-dose radiation plus chemotherapy. The goal is to see if this gentler approach can keep the cancer from coming back while…

This study is testing whether a blood test that detects HPV DNA can help doctors decide who needs radiation after surgery for HPV-related oropharynx cancer. In one group, patients with no detectable HPV DNA after surgery will be watched closely and only get radiation if the test …

This study tests a new drug called volrustomig combined with standard chemotherapy (paclitaxel and carboplatin) in people with advanced head and neck cancer that is not caused by HPV. The goal is to see if this combination shrinks tumors before further treatment is tailored based…

This study tests a supplement called Papillex® to see if it can help reverse abnormal cervical cells caused by HPV. Researchers will compare Papillex® to a placebo in 60 women with mild to moderate cervical changes (CIN 1 or 2). Participants take the supplement daily for 180 days…

This study tests whether offering a self-sampling kit for HPV in the emergency department can increase the number of people who get screened for cervical cancer. About 200 eligible individuals (ages 30-65 with a cervix) will be offered the kit while in the ED. The goal is to see …

This study aims to make cervical cancer screening more convenient by offering HPV self-collection kits that women can use at home or in the clinic. Researchers will enroll 1,000 women aged 25-65 who are overdue for screening. The goal is to see how many women complete the test an…

This study is testing whether a special menstrual pad, called the Q-Pad, can accurately detect high-risk HPV from menstrual blood collected at home. About 450 people who need a colposcopy after an abnormal Pap or HPV test will use the pad during their period and mail it to a lab.…

This study explores whether women can accurately collect their own samples for HPV testing, which could make cervical cancer screening easier and more accessible. The research focuses on minority women who are often under-screened, using community health workers to help with the …

This study tests whether giving nurses and doctors special training and allowing nurses to give the HPV vaccine without a doctor's order can increase vaccination rates. About 16,000 teens aged 9-17 from 40 medical practices will take part. The goal is to prevent HPV-related cance…

This pilot study tests whether a health-themed video game can encourage HPV vaccination among underserved youth aged 11-14 who have not yet received the vaccine. About 180 parent-child pairs will play the game and report their vaccination intentions and actual shots. The goal is …

This study tests a community-based approach to make cervical cancer screening easier for women who haven't had a Pap test in over 3.5 years. It involves 920 women in low-resource areas of Texas. The goal is to see if this strategy is safe and works well.

This study tests whether people living with HIV can accurately collect their own swab samples to screen for HPV, a virus that can lead to anal cancer. Researchers will compare self-swabs to those taken by a doctor and ask participants which method they prefer. If self-screening w…

This study looks at people who have had unusually severe or long-lasting viral infections, like serious cases of herpes, HPV, or the flu. Researchers want to find out if these people have hidden immune system or genetic problems that make them more vulnerable. Up to 600 participa…

This study looks at anal cancer risk in men who have sex with men (MSM) who take PrEP to prevent HIV. Researchers want to find out how common high-grade anal lesions are, how well anal swabs detect them, and how these lesions affect quality of life. About 296 participants will an…

This study looks at how different menstrual products—tampons, cups, and pads—affect the bacteria and immune cells in the vagina. Researchers will collect samples from 300 women aged 18-49 to compare these groups. The goal is to understand if internal products like tampons and cup…

This study looks at whether testing for HPV DNA from a cervical swab or a blood sample can help find cervical cancer that has come back after radiotherapy. Researchers will follow 120 patients for two years after treatment, collecting samples at regular visits. The goal is to see…

This study looks at whether it's practical to surgically remove a type of eye surface tumor (OSSN) in people living with HIV in Sub-Saharan Africa. About 84 participants will have the tumor cut out and be followed for a year to see if the procedure is safe and if patients return …

This study follows 300 women aged 18–40 with severe cervical precancer (CIN 2 or 3) to see how often these lesions regress on their own or after surgery. Researchers will track HPV and Pap test results to identify factors that predict healing. The goal is to create a model that h…

This study looks at 400 women living with HIV to understand how the bacteria in their gut and vagina might influence HPV infection and cervical changes. Researchers will collect samples to see if an imbalance in vaginal bacteria makes these women more likely to get HPV and develo…

This study is testing a mobile app called mSaada that helps community health workers educate women, track screening, and send reminders for cervical cancer screening. The trial involves 6,000 women and health workers across 12 health facilities in western Kenya. The goal is to se…