HPV

This early-phase trial tests a new vaccine called PANHPVAX in 45 healthy adults aged 18-45. The vaccine targets a part of the HPV virus (L2 antigen) to potentially prevent HPV infections. The main goal is to check safety and how well the body's immune system responds to different…

This study tests if a fun, game-based program can encourage HPV vaccination in underserved youth aged 11-14. Researchers will measure how many families agree to join, complete the program, and ultimately get the vaccine. The goal is to prevent HPV-related cancers by making vaccin…

This study looks at whether two doses of the HPV vaccine can protect women living with HIV as well as the standard three doses. Researchers will enroll 275 women across Canada and compare immune responses over two years. If successful, fewer doses could make HPV vaccination cheap…

This study is for people with early-stage HPV-positive throat cancer. Standard treatment uses full-dose radiation plus chemotherapy, which can cause long-term side effects. The study tests whether giving only lower-dose radiation (no chemo) can keep the cancer from coming back wh…

This study tests whether a supplement called Papillex® can help reverse abnormal cervical cells caused by HPV in women with mild to moderate cervical changes (CIN 1 or 2). Sixty women will take either Papillex® or a placebo daily for 180 days. Researchers will compare Pap smear a…

This study is for people with HPV-positive throat cancer. It tests whether a much lower dose of radiation (30 Gy) combined with standard chemotherapy works as well as the usual high dose (70 Gy) to control the cancer, while causing fewer side effects. About 121 participants will …

This study tests a combination of three drugs (volrustomig, paclitaxel, and carboplatin) in people with untreated HPV-negative head and neck cancer that has spread locally but not to other parts of the body. The goal is to see how many patients experience significant tumor shrink…

This study is for people with HPV-related throat cancer who have had or will have surgery. Researchers will use a blood test that looks for cancer DNA (HPV ctDNA) to decide if radiation therapy is needed. In one group, patients with no detectable cancer DNA after surgery will ski…

This study is testing whether a special menstrual pad (Q-Pad) can accurately detect high-risk HPV from period blood collected at home. About 450 people who need a colposcopy after an abnormal Pap or HPV test will use the pad during their period and mail it to a lab. Researchers w…

This study explores whether offering a simple self-sampling test for HPV in the emergency department can help more people get screened for cervical cancer. About 200 eligible individuals (ages 30–65 with a cervix) will be invited to provide a self-sample during their ED visit. Th…

This study explores whether women from underserved communities can accurately collect their own samples to test for HPV, the virus that can cause cervical cancer. Researchers will compare results from two different self-collection kits to standard Pap smears. The goal is to make …

This study tests whether giving nurses and staff the authority to give the HPV vaccine without a doctor's order (called standing orders) can increase vaccination rates in teens. About 16,000 patients aged 9-17 from 40 medical practices will take part. The goal is to prevent HPV-r…

This study aims to make cervical cancer screening easier for women in low-resource areas of Texas. It involves 920 women aged 25 and older who haven't had a Pap test in over 3.5 years. The approach uses community-based strategies to increase access and participation.

This study looks at the best ways to offer HPV self-collection kits to women who are overdue for cervical cancer screening. Participants can collect their own sample at home or in a clinic, instead of having a Pap test. The goal is to see how many women use the kits and follow up…

This study looks at how different menstrual products—tampons, cups, and pads—affect the bacteria and immune cells in the vagina. Researchers will collect samples from 300 women aged 18-49 to compare these groups. The goal is to understand if internal products like tampons and cup…

This study is testing a mobile health tool called mSaada to help community health workers screen women for cervical cancer in western Kenya. Researchers will work with 6,000 women and health volunteers to see if the app makes screening easier and more effective. The goal is to fi…

This study looks at 400 women living with HIV to understand how the bacteria in their gut and vagina may influence HPV infection and cervical cell changes. Researchers will collect samples to see if an imbalance in vaginal bacteria makes these women more likely to get HPV and dev…

This study looks for immune system problems that might make some people get very sick from viruses like herpes, chickenpox, or HPV. Researchers will test blood and skin samples from up to 600 people who have had severe viral infections, along with their relatives. The goal is to …

This study looks at whether testing for HPV after radiation treatment for cervical cancer can help find cancer that has come back. Researchers will collect samples from 120 patients before and up to two years after treatment. The goal is to see if HPV testing is better than curre…

This study looks at how common anal cancer risk signs are in HIV-negative men who have sex with men (MSM) using PrEP. About 300 participants will answer health questions, provide an anal swab, and undergo a special exam called High-Resolution Anoscopy. The goal is to see how well…

This study looks at whether it's practical to do surgery for a type of eye cancer (OSSN) in people with HIV in Sub-Saharan Africa. About 84 participants will have the tumor removed and be checked for up to a year. The goal is to see if a larger study can be done safely and effect…

This study follows 300 women aged 18–40 with severe cervical precancer (CIN 2 or 3) to see how often these lesions shrink or disappear without surgery. Researchers will compare those who are monitored closely with those who receive standard cone biopsy, tracking HPV clearance and…

This study tests whether people living with HIV can collect their own swab samples to screen for HPV, a virus that can lead to anal cancer. Researchers will compare the accuracy and comfort of self-screening versus a traditional swab done by a healthcare professional. The goal is…