OROPHARYNGEAL CANCER

This study tests whether using a SPECT-CT scan to map lymph nodes can allow doctors to safely give radiation only to the side of the neck where the cancer is, instead of both sides. About 510 people with oropharyngeal cancer that has not spread to the middle of the throat will be…

This study is for people with HPV-positive throat cancer. It tests whether a much lower dose of radiation (30 Gy) combined with standard chemotherapy works as well as the usual high dose (70 Gy) to control the cancer, while causing fewer side effects. About 121 participants will …

This study tests whether giving the immunotherapy drug toripalimab with chemotherapy before standard treatment can shrink HPV-related throat cancer tumors by at least half. About 30 people with advanced HPV16-positive oropharyngeal cancer will receive the drug combo, then either …

This study tests whether a blood test that detects tumor DNA can help doctors choose the right amount of chemotherapy and radiation after surgery for HPV-related throat cancer. The goal is to give each patient just enough treatment to prevent the cancer from coming back, while re…

This study tests giving chemotherapy and an immunotherapy drug before standard surgery for head and neck cancer. The goal is to shrink tumors enough so that surgeons can perform a less extensive operation, preserving speech, swallowing, and vision. The trial enrolls 75 adults wit…

This study tests whether giving a personalized, less intense treatment plan to people with early-stage HPV-related throat cancer can keep the cancer from coming back while reducing side effects. About 150 participants will either have surgery followed by observation or limited ra…

This study is testing a new mouth swab test that looks for HPV DNA and certain gene changes to find throat cancer early. Researchers will compare results from 200 people with throat cancer and 200 healthy volunteers matched by age, sex, and background. If the test works well, it …

This study tests whether injecting a long-lasting anesthetic (EXPAREL) into the surgical wound during robotic throat surgery can reduce pain, lower the need for opioids, and help patients swallow better after the operation. About 80 adults with oropharyngeal cancer will take part…

This study is testing whether liquid biopsies (blood tests that look for bits of HPV DNA) can help doctors monitor how well treatment is working for HPV-related cancers, like cervical and oropharyngeal cancer. Researchers will follow 480 people for up to 4 years, collecting sampl…

This study is creating a large database of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand what causes cancer, how it progresses, and how to improve p…