New imaging technique may spare throat cancer patients from unnecessary radiation

NCT ID NCT05451004

Recruiting now Disease control Sponsor: Canadian Cancer Trials Group Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 15, 2026 · Updated 2 times

Summary

This phase 3 trial tests whether using a special scan (SPECT-CT) to guide radiation to only one side of the neck works as well as standard radiation to both sides for people with oropharyngeal cancer. The study includes 510 participants with early-stage cancer on one side of the throat. The goal is to see if this targeted approach can reduce side effects like swallowing difficulties and dry mouth without increasing the risk of cancer returning.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Radiotherapy
What this could lead to: If successful, this approach could reduce side effects like swallowing problems and dry mouth while maintaining cancer control.
What could go wrong: This is a large phase 3 trial, but it's still possible that the guided treatment leads to higher cancer recurrence. Results are not yet available.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

oropharyngeal carcinoma oropharynx cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OROPHARYNGEAL CANCER

Contacts and locations

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Locations

BCCA-Vancouver Cancer Centre
RECRUITING

Vancouver, British Columbia, V5Z 4E6, Canada
Baptist MD Anderson Cancer Center
ACTIVE_NOT_RECRUITING

Jacksonville, Florida, 32207, United States
CHUM - Centre Hospitalier de l'Universite de Montreal
RECRUITING

Montreal, Quebec, H2X 3E4, Canada
CancerCare Manitoba
RECRUITING

Winnipeg, Manitoba, R3E 0V9, Canada
Central Vermont Medical Center/National Life Cancer Treatment
RECRUITING

Berlin Corners, Vermont, 05602, United States
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
RECRUITING

Sherbrooke, Quebec, J1H 5N4, Canada
City of Hope Comprehensive Cancer Center
RECRUITING

Duarte, California, 91010, United States

Contact Email: •••••@•••••
City of Hope Corona
RECRUITING

Corona, California, 92882, United States

Contact Email: •••••@•••••
City of Hope at Irvine Lennar
SUSPENDED

Irvine, California, 92618, United States
Emory University Hospital Midtown
RECRUITING

Atlanta, Georgia, 30308, United States
Health Sciences North
RECRUITING

Greater Sudbury, Ontario, P3E 5J1, Canada
Henry Ford Hospital
RECRUITING

Detroit, Michigan, 48202, United States

Contact Email: •••••@•••••
Jewish General Hospital
ACTIVE_NOT_RECRUITING

Montreal, Quebec, H3T 1E2, Canada
Juravinski Cancer Centre at Hamilton Health Sciences
RECRUITING

Hamilton, Ontario, L8V 5C2, Canada
MU Health - University Hospital/Ellis Fischel Cancer Center
RECRUITING

Columbia, Missouri, 65212, United States
MetroHealth Medical Center
RECRUITING

Cleveland, Ohio, 44109, United States
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States

Contact Email: •••••@•••••
Moffitt Cancer Center - McKinley Campus
RECRUITING

Tampa, Florida, 33612, United States

Contact Email: •••••@•••••
Moffitt Cancer Center-International Plaza
RECRUITING

Tampa, Florida, 33607, United States

Contact Email: •••••@•••••
Northwestern Medicine Cancer Center Warrenville
ACTIVE_NOT_RECRUITING

Warrenville, Illinois, 60555, United States
Northwestern University
ACTIVE_NOT_RECRUITING

Chicago, Illinois, 60611, United States
Odette Cancer Centre- Sunnybrook Health Sciences Centre
SUSPENDED

Toronto, Ontario, M4N 3M5, Canada
Providence Portland Medical Center
RECRUITING

Portland, Oregon, 97213, United States

Contact Email: •••••@•••••
Saint Joseph's Healthcare Charlton Campus
SUSPENDED

Hamilton, Ontario, L8N 4A6, Canada
The James Graham Brown Cancer Center at University of Louisville
SUSPENDED

Louisville, Kentucky, 40202, United States
UM Sylvester Comprehensive Cancer Center at Coral Gables
RECRUITING

Coral Gables, Florida, 33146, United States
UNC Lineberger Comprehensive Cancer Center
RECRUITING

Chapel Hill, North Carolina, 27599, United States

Contact Email: •••••@•••••
UT MD Anderson - League City
RECRUITING

League City, Texas, 77573, United States
UT MD Anderson - Sugar Land
RECRUITING

Sugar Land, Texas, 77478, United States
UT MD Anderson - The Woodlands
RECRUITING

Conroe, Texas, 77384, United States
UT MD Anderson - West Houston
RECRUITING

Houston, Texas, 77079, United States
UT MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
University Health Network-Princess Margaret Hospital
RECRUITING

Toronto, Ontario, M5G 2M9, Canada

Contact Email: •••••@•••••
University of Miami Miller School of Medicine-Sylvester Cancer Center
RECRUITING

Miami, Florida, 33136, United States
University of Michigan - Brighton Center for Specialty Care
RECRUITING

Brighton, Michigan, 48116, United States
University of Michigan Rogel Cancer Center
RECRUITING

Ann Arbor, Michigan, 48109, United States

Contact Email: •••••@•••••
University of Vermont Medical Center
RECRUITING

Burlington, Vermont, 05401, United States
University of Vermont and State Agricultural College
RECRUITING

Burlington, Vermont, 05405, United States

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