Canadian Cancer Trials Group

This study is testing if adding a new drug called zanidatamab to the standard two-drug treatment works better to control advanced stomach and esophageal cancer that has a specific marker (HER2-positive). It will involve 168 adults whose cancer has worsened despite previous treatm…

This study is testing whether women with low-risk breast cancer can safely skip radiation to the lymph node areas. Researchers want to know if avoiding this radiation works just as well at preventing cancer from returning while reducing treatment side effects. The trial will comp…

This study compares two radiation treatments for patients whose cancer has spread to the brain (5-15 tumors). One treatment uses highly focused radiation on just the tumors (SRS), while the other treats the whole brain but tries to spare the memory center, combined with a drug (m…

This study is testing whether doctors can safely use less intensive follow-up treatments for early-stage endometrial cancer based on the genetic makeup of each patient's tumor. The research involves 393 women who have already had surgery to remove their cancer. The goal is to see…

This study compares two radiation treatment approaches for men with high-risk prostate cancer. It tests whether a shorter, more intense radiation schedule (SBRT) works as well as the standard approach of external radiation plus a brachytherapy boost (where radioactive seeds are p…

This study is testing if adding a second chemotherapy drug, carboplatin, to the standard drug docetaxel can help men with advanced prostate cancer that has stopped responding to hormone therapy. The goal is to see if this combination can slow the cancer's growth and help patients…

This study is testing if adding precise, high-dose radiation to standard drug treatment can better control advanced lung cancer that has started to spread to a few new spots. It will compare this combined approach against switching to new drugs alone in 320 patients. The goal is …

This study is testing if a blood test can help doctors make better treatment decisions for people with advanced lung cancer. The test looks for tiny bits of cancer DNA in the blood. If the DNA is still found after 6 weeks of standard immunotherapy, the study will see if adding ch…

This trial is for people with advanced breast cancer that has stopped responding to a common first-line treatment. Researchers will use a simple blood test to look for genetic clues in the cancer. Based on those clues, patients will be matched with one of several new experimental…

This study is testing whether using special imaging to guide radiation treatment to only the affected side of the neck works as well as treating both sides for patients with throat cancer that hasn't spread across the midline. Researchers want to see if this more targeted approac…

This study is testing if changing the bacteria in a patient's gut, using a treatment called a fecal microbiota transplant (FMT), can make standard immunotherapy work better against advanced melanoma. About 128 patients will be randomly assigned to receive either the standard immu…

This study is testing if a new combination of two drugs (pembrolizumab and brentuximab vedotin) works better than the current standard treatment for classical Hodgkin lymphoma that has come back or not responded to initial chemotherapy. The goal is to shrink or eliminate the canc…

This study is testing if stopping a key injection drug (daratumumab or isatuximab) after about 18 months works as well as continuing it indefinitely for older adults with multiple myeloma who are not eligible for a stem cell transplant. About 570 participants who have already res…

This early study aims to find the safest, highest dose of a new drug when combined with standard lymphoma chemotherapy. It's for adults whose aggressive B-cell lymphoma has returned or hasn't responded to prior treatment. Researchers will carefully increase the dose for small gro…

This large international study is testing if adding a chemotherapy drug (docetaxel) to the standard hormone therapy helps men with advanced prostate cancer that has spread. The goal is to see if this combination can better control the cancer and help patients live longer compared…

This large, late-stage trial is testing whether a combination of two immunotherapy drugs (botensilimab and balstilimab) helps people with advanced colorectal cancer live longer than standard supportive care. The study involves over 800 adults whose cancer cannot be surgically rem…

This study aims to find out if taking planned breaks from standard immunotherapy works as well as taking it continuously for people with advanced melanoma. Researchers will compare two groups: one receiving treatment non-stop for up to two years, and another taking breaks when th…

This study is testing whether adding a third drug (lenvatinib) to a two-drug immunotherapy combination (durvalumab + tremelimumab) works better for controlling advanced liver cancer that cannot be removed by surgery. It will involve about 140 adults who have not yet received drug…

This study is testing new immunotherapy drug combinations for women with advanced ovarian cancer that has stopped responding to standard platinum-based chemotherapy. Researchers will enroll 60 participants to see if these experimental treatments can shrink tumors and extend life …

This study aims to see if matching existing cancer drugs to the specific genetic changes found in a person's tumor can help control advanced cancers. It is for adults with certain advanced solid tumors, lymphoma, or multiple myeloma who have run out of standard treatment options.…

This study is testing whether adding the drug ibrutinib to standard chemotherapy can better control a rare and aggressive cancer called primary central nervous system lymphoma (PCNSL). It is for adults who are not eligible for a stem cell transplant. The goal is to see if this co…

This study aims to see if lab tests on a woman's vulvar cancer tissue can help doctors recommend the right amount of surgery. For early-stage cancer, researchers will test if the tumor is linked to HPV (a common virus) and check other markers. Based on these results, some partici…

This study compares two treatment approaches for early rectal cancer. One group receives chemotherapy alone before limited surgery, while the other receives both chemotherapy and radiation therapy before surgery. Researchers want to see if both approaches work equally well at shr…

This study is testing whether a newer, more precise form of radiation therapy works better than standard radiation for people with advanced head and neck cancer who are not candidates for curative treatment. It will compare a shorter course of stronger, targeted radiation (SBRT) …

This study is testing whether a new support program called EASE can help reduce the severe emotional distress and physical symptoms people often experience after being diagnosed with acute leukemia. About 266 newly diagnosed patients will be randomly assigned to receive either th…

This study compares two radiation treatments for people with painful bone metastases from cancer. It tests whether a more precise, targeted radiation (SBRT) provides better and longer-lasting pain relief than the standard radiation treatment (CRT). The trial will enroll 230 parti…

This study is testing whether a 4-week mindfulness app can help cancer survivors manage stress, anxiety, and fatigue after finishing their main cancer treatments. About 345 participants will either use the app right away or wait 3 months to use it, allowing researchers to compare…

This study tracks healthcare costs and patient quality of life for Canadians with high-risk chronic lymphocytic leukemia. It compares starting newer treatments immediately versus waiting until symptoms appear. Researchers will follow 247 patients for up to 10 years to understand …