Blood test could match resistant breast cancer to best drug

NCT ID NCT05601440

Recruiting now Disease control Sponsor: Canadian Cancer Trials Group Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This phase 2 trial is testing whether a liquid biopsy (a simple blood test) can help choose the right treatment for people with ER+/HER2- metastatic breast cancer that has stopped responding to standard therapies. About 484 participants will be assigned to one of several drug arms or an observation group based on their tumor's DNA markers. The goal is to see if biomarker-guided treatment improves response rates and survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Lunresertib, Gemcitabine, Niraparib, Fulvestrant, Camonsertib, CFI-402257, CFI-400945, Sacituzumab govitecan
What this could lead to: If successful, this could show that using a simple blood test to pick treatments improves outcomes for people with hard-to-treat breast cancer.
What could go wrong: This is a mid-stage trial with many different drugs, so results may take years and some arms may not work. Side effects from the various drugs are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm estrogen-receptor positive breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER

Contacts and locations

Locations

Arthur J.E. Child Comprehensive Cancer Centre
RECRUITING

Calgary, Alberta, T2N 5G2, Canada
BCCA - Kelowna
RECRUITING

Kelowna, British Columbia, V1Y 5L3, Canada
BCCA - Vancouver
RECRUITING

Vancouver, British Columbia, V5Z 4E6, Canada
Juravinski Cancer Centre at Hamilton Health Sciences
RECRUITING

Hamilton, Ontario, L8V 5C2, Canada
Kingston Health Sciences Centre
RECRUITING

Kingston, Ontario, K7L 2V7, Canada
Odette Cancer Centre
SUSPENDED

Toronto, Ontario, M4N 3M5, Canada
Ottawa Hospital Research Institute
RECRUITING

Ottawa, Ontario, K1H 8L6, Canada
QEII Health Sciences Centre
RECRUITING

Halifax, Nova Scotia, B3H 1V7, Canada
The Jewish General Hospital
RECRUITING

Montreal, Quebec, H3T 1E2, Canada
University Health Network
RECRUITING

Toronto, Ontario, M5G 2M9, Canada

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