Radiation boost may stall lung cancer spread

NCT ID NCT06686771

Recruiting now Disease control Sponsor: Canadian Cancer Trials Group Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 15, 2026 · Updated 3 times

Summary

This study tests whether adding targeted radiotherapy (SBRT) to standard drug therapy can slow or stop lung cancer from growing in people with metastatic non-small cell lung cancer. About 320 participants whose cancer has started to progress on first-line treatment will receive either standard drugs alone or drugs plus radiotherapy. The goal is to see if the combination improves progression-free and overall survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: SBRT (targeted radiotherapy)
What this could lead to: If successful, adding radiotherapy to standard drug therapy could help control lung cancer growth and extend the time before the disease worsens.
What could go wrong: This is a Phase 3 trial, but results are not guaranteed. Radiotherapy may cause side effects, and the benefit over standard care alone may be small or absent.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER

Contacts and locations

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Locations

Alton Memorial Hospital
RECRUITING

Alton, Illinois, 62002, United States
CTCA at Southeastern Regional Medical Center
RECRUITING

Newnan, Georgia, 30265, United States
CancerCare Manitoba
RECRUITING

Winnipeg, Manitoba, R3E 0V9, Canada
City of Hope Comprehensive Cancer Center
RECRUITING

Duarte, California, 91010, United States

Contact Email: •••••@•••••
City of Hope at Irvine Lennar
RECRUITING

Irvine, California, 92618, United States
Coborn Cancer Center at Saint Cloud Hospital
RECRUITING

Saint Cloud, Minnesota, 56303, United States

Contact Email: •••••@•••••
Cross Cancer Institute
RECRUITING

Edmonton, Alberta, T6G 1Z2, Canada
Crossroads Cancer Center
RECRUITING

Effingham, Illinois, 62401, United States
Decatur Memorial Hospital
RECRUITING

Decatur, Illinois, 62526, United States
Geisinger Medical Center
RECRUITING

Danville, Pennsylvania, 17822, United States

Contact Email: •••••@•••••
Geisinger Medical Oncology-Lewisburg
RECRUITING

Lewisburg, Pennsylvania, 17837, United States

Contact Email: •••••@•••••
Geisinger Wyoming Valley/Henry Cancer Center
RECRUITING

Wilkes-Barre, Pennsylvania, 18711, United States

Contact Email: •••••@•••••
HSHS Saint Elizabeth's Hospital
RECRUITING

O'Fallon, Illinois, 62269, United States
Iowa Methodist Medical Center
RECRUITING

Des Moines, Iowa, 50309, United States
Lenox Hill Hospital
RECRUITING

New York, New York, 10075, United States
Manhattan Eye Ear and Throat Hospital
RECRUITING

New York, New York, 10065, United States
Mayo Clinic Hospital in Arizona
RECRUITING

Phoenix, Arizona, 85054, United States
Mayo Clinic in Rochester
RECRUITING

Rochester, Minnesota, 55905, United States
Memorial Hospital East
RECRUITING

Shiloh, Illinois, 62269, United States
Mercy Hospital
RECRUITING

Cedar Rapids, Iowa, 52403, United States
Mercy Medical Center - Des Moines
RECRUITING

Des Moines, Iowa, 50314, United States
Miller-Dwan Hospital
RECRUITING

Duluth, Minnesota, 55805, United States

Contact Email: •••••@•••••
Montefiore Medical Center - Moses Campus
RECRUITING

The Bronx, New York, 10467, United States
Montefiore Medical Center-Einstein Campus
RECRUITING

The Bronx, New York, 10461, United States
Mount Sinai Chelsea
RECRUITING

New York, New York, 10011, United States
Mount Sinai Hospital
RECRUITING

New York, New York, 10029, United States
Mount Sinai West
RECRUITING

New York, New York, 10019, United States
Nebraska Medicine-Bellevue
RECRUITING

Bellevue, Nebraska, 68123, United States
Nebraska Medicine-Village Pointe
RECRUITING

Omaha, Nebraska, 68118, United States
Northwell Health/Center for Advanced Medicine
RECRUITING

Lake Success, New York, 11042, United States
Northwest Wisconsin Cancer Center
RECRUITING

Ashland, Wisconsin, 54806, United States

Contact Email: •••••@•••••
Northwestern Medicine Cancer Center Delnor
RECRUITING

Geneva, Illinois, 60134, United States
Northwestern Medicine Cancer Center Kishwaukee
RECRUITING

DeKalb, Illinois, 60115, United States
Northwestern Medicine Cancer Center Warrenville
RECRUITING

Warrenville, Illinois, 60555, United States
Northwestern Medicine Glenview Outpatient Center
RECRUITING

Glenview, Illinois, 60026, United States
Northwestern Medicine Grayslake Outpatient Center
RECRUITING

Grayslake, Illinois, 60030, United States
Northwestern Medicine Lake Forest Hospital
RECRUITING

Lake Forest, Illinois, 60045, United States

Contact Email: •••••@•••••
Northwestern Medicine Oak Brook
RECRUITING

Oak Brook, Illinois, 60523, United States
Northwestern Medicine Orland Park
RECRUITING

Orland Park, Illinois, 60462, United States
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States

Contact Email: •••••@•••••
Odette Cancer Centre- Sunnybrook Health Sciences Centre
RECRUITING

Toronto, Ontario, M4N 3M5, Canada
Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States
Oncology Associates at Mercy Medical Center
RECRUITING

Cedar Rapids, Iowa, 52403, United States
Penn State Milton S Hershey Medical Center
RECRUITING

Hershey, Pennsylvania, 17033-0850, United States
Queens Cancer Center
RECRUITING

Rego Park, New York, 11374, United States
Saint Francis Medical Center
RECRUITING

Cape Girardeau, Missouri, 63703, United States
Saint Luke's Cancer Institute - Boise
RECRUITING

Boise, Idaho, 83712, United States
Saint Luke's Cancer Institute - Fruitland
RECRUITING

Fruitland, Idaho, 83619, United States
Saint Luke's Cancer Institute - Meridian
RECRUITING

Meridian, Idaho, 83642, United States
Saint Luke's Cancer Institute - Nampa
RECRUITING

Nampa, Idaho, 83687, United States
Saint Mary's Hospital and Regional Medical Center
RECRUITING

Grand Junction, Colorado, 81501, United States
Siteman Cancer Center at Christian Hospital
RECRUITING

St Louis, Missouri, 63136, United States

Contact Email: •••••@•••••
Siteman Cancer Center at Saint Peters Hospital
RECRUITING

City of Saint Peters, Missouri, 63376, United States

Contact Email: •••••@•••••
Siteman Cancer Center at West County Hospital
RECRUITING

Creve Coeur, Missouri, 63141, United States

Contact Email: •••••@•••••
Siteman Cancer Center-South County
RECRUITING

St Louis, Missouri, 63129, United States

Contact Email: •••••@•••••
State University of New York Upstate Medical University
RECRUITING

Syracuse, New York, 13210, United States
Stony Brook University Medical Center
RECRUITING

Stony Brook, New York, 11794, United States
The Don and Sybil Harrington Cancer Center
RECRUITING

Amarillo, Texas, 79106, United States
Thomas Jefferson University Hospital
RECRUITING

Philadelphia, Pennsylvania, 19107, United States

Contact Email: •••••@•••••
UI Health Care Mission Cancer and Blood - Ankeny Clinic
RECRUITING

Ankeny, Iowa, 50023, United States
UI Health Care Mission Cancer and Blood - Des Moines Clinic
RECRUITING

Des Moines, Iowa, 50309, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic
RECRUITING

Des Moines, Iowa, 50314, United States
UI Health Care Mission Cancer and Blood - Waukee Clinic
RECRUITING

Waukee, Iowa, 50263, United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
RECRUITING

Clive, Iowa, 50325, United States
UI Healthcare Mission Cancer and Blood - Pella
RECRUITING

Pella, Iowa, 50219, United States

Contact Email: •••••@•••••
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
RECRUITING

Mechanicsburg, Pennsylvania, 17050, United States
UPMC-Shadyside Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
University Health Network-Princess Margaret Hospital
RECRUITING

Toronto, Ontario, M5G 2M9, Canada

Contact Email: •••••@•••••
University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198, United States
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of Rochester
RECRUITING

Rochester, New York, 14642, United States
VCU Massey Cancer Center at Stony Point
RECRUITING

Richmond, Virginia, 23235, United States
VCU Massey Comprehensive Cancer Center
RECRUITING

Richmond, Virginia, 23298, United States
Vanderbilt University/Ingram Cancer Center
RECRUITING

Nashville, Tennessee, 37232, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

Contact Email: •••••@•••••

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