Canadian trial matches cancer drugs to gene mutations

NCT ID NCT03297606

Recruiting now Disease control Sponsor: Canadian Cancer Trials Group Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether giving cancer patients a targeted therapy that matches a specific gene change in their tumor can help shrink or control the cancer. It includes 720 adults with advanced solid tumors, multiple myeloma, or non-Hodgkin lymphoma who have no standard treatment options. Participants receive one of several targeted drugs based on their cancer's genetic profile.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Olaparib, Dasatinib, Nivolumab plus Ipilimumab, Axitinib, Bosutinib, Crizotinib (targeted therapies)
What this could lead to: If successful, this trial could show that matching targeted drugs to a patient's specific gene changes helps shrink or control advanced cancers that have not responded to standard treatments.
What could go wrong: This is a phase II trial, so it is still early. The drugs may not work for many patients, and side effects could be serious. Results may not apply to all cancer types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

B-cell non-Hodgkin lymphoma lymphoma, non-Hodgkin, familial metastatic malignant neoplasm non-Hodgkin lymphoma plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMORS LYMPHOMA, NON-HODGKIN MULTIPLE MYELOMA

Contacts and locations

Locations

Allan Blair Cancer Centre
RECRUITING

Regina, Saskatchewan, S4T 7T1, Canada
BCCA - Kelowna
RECRUITING

Kelowna, British Columbia, V1Y 5L3, Canada
BCCA - Vancouver
RECRUITING

Vancouver, British Columbia, V5Z 4E6, Canada
Cross Cancer Institute
RECRUITING

Edmonton, Alberta, T6G 1Z2, Canada
Kingston Health Sciences Centre
RECRUITING

Kingston, Ontario, K7L 2V7, Canada
London Health Sciences Centre Research Inc.
RECRUITING

London, Ontario, N6A 5W9, Canada
Ottawa Hospital Research Institute
RECRUITING

Ottawa, Ontario, K1H 8L6, Canada
Saskatoon Cancer Centre
RECRUITING

Saskatoon, Saskatchewan, S7N 4H4, Canada
The Jewish General Hospital
RECRUITING

Montreal, Quebec, H3T 1E2, Canada
University Health Network
RECRUITING

Toronto, Ontario, M5G 2M9, Canada

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