Could early rectal cancer patients skip radiation? new trial aims to find out

NCT ID NCT06205485

Recruiting now Disease control Sponsor: Canadian Cancer Trials Group Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 15, 2026 · Updated 2 times

Summary

This study tests whether giving chemotherapy alone before limited surgery works as well as chemotherapy plus radiation for early rectal cancer. The goal is to see if avoiding radiation improves quality of life without harming cancer control. About 250 adults with early-stage rectal cancer will take part.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

rectal cancer rectal neoplasm rectum adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RECTAL CANCER

Contacts and locations

Show contact details

Locations

Addison Gilbert Hospital
RECRUITING

Gloucester, Massachusetts, 01930, United States
Allan Blair Cancer Centre
RECRUITING

Regina, Saskatchewan, S4T 7T1, Canada
Allegiance Health
RECRUITING

Jackson, Michigan, 49201, United States

Contact Email: •••••@•••••
Atrium Medical Center-Middletown Regional Hospital
RECRUITING

Franklin, Ohio, 45005-1066, United States

Contact Email: •••••@•••••
BCCA-Vancouver Cancer Centre
RECRUITING

Vancouver, British Columbia, V5Z 4E6, Canada
Beebe Health Campus
RECRUITING

Rehoboth Beach, Delaware, 19971, United States

Contact Email: •••••@•••••
Beebe South Coastal Health Campus
RECRUITING

Millville, Delaware, 19967, United States

Contact Email: •••••@•••••
Beverly Hospital
RECRUITING

Beverly, Massachusetts, 01915, United States
CIUSSSEMTL-Hopital Maisonneuve-Rosemont
RECRUITING

Montreal, Quebec, H1T 2M4, Canada
Cancer Center at Saint Joseph's
RECRUITING

Phoenix, Arizona, 85004, United States

Contact Email: •••••@•••••
CancerCare Manitoba
RECRUITING

Winnipeg, Manitoba, R3E 0V9, Canada
Carle Cancer Center
RECRUITING

Urbana, Illinois, 61801, United States

Contact Email: •••••@•••••
Carle Physician Group-Effingham
RECRUITING

Effingham, Illinois, 62401, United States

Contact Email: •••••@•••••
Carle Physician Group-Mattoon/Charleston
RECRUITING

Mattoon, Illinois, 61938, United States

Contact Email: •••••@•••••
Carle at The Riverfront
RECRUITING

Danville, Illinois, 61832, United States

Contact Email: •••••@•••••
Christiana Care Health System-Concord Health Center
RECRUITING

Chadds Ford, Pennsylvania, 19317, United States
Clackamas Radiation Oncology Center
RECRUITING

Clackamas, Oregon, 97015, United States

Contact Email: •••••@•••••
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
RECRUITING

Grand Rapids, Michigan, 49503, United States
Dartmouth Cancer Center - North
RECRUITING

Saint Johnsbury, Vermont, 05819, United States
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
RECRUITING

Lebanon, New Hampshire, 03756, United States
Doctor H. Bliss Murphy Cancer Centre
RECRUITING

St. John's, Newfoundland and Labrador, A1B 3V6, Canada
East Carolina University
RECRUITING

Greenville, North Carolina, 27834, United States
Emory Saint Joseph's Hospital
RECRUITING

Atlanta, Georgia, 30342, United States
Emory University Hospital Midtown
RECRUITING

Atlanta, Georgia, 30308, United States
Emory University Hospital/Winship Cancer Institute
RECRUITING

Atlanta, Georgia, 30322, United States
FHCC Overlake
RECRUITING

Bellevue, Washington, 98004, United States
FHCC at EvergreenHealth
RECRUITING

Kirkland, Washington, 98034, United States
FHCC at Northwest Hospital
RECRUITING

Seattle, Washington, 98133, United States
Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109, United States
Helen F Graham Cancer Center
RECRUITING

Newark, Delaware, 19713, United States
Henry Ford Cancer Institute-Downriver
RECRUITING

Brownstown, Michigan, 48183, United States

Contact Email: •••••@•••••
Henry Ford Hospital
RECRUITING

Detroit, Michigan, 48202, United States

Contact Email: •••••@•••••
Henry Ford Macomb Hospital-Clinton Township
RECRUITING

Clinton Township, Michigan, 48038, United States

Contact Email: •••••@•••••
Henry Ford Medical Center-Columbus
RECRUITING

Novi, Michigan, 48377, United States

Contact Email: •••••@•••••
Henry Ford Medical Center-Fairlane
RECRUITING

Dearborn, Michigan, 48126, United States

Contact Email: •••••@•••••
Henry Ford West Bloomfield Hospital
RECRUITING

West Bloomfield, Michigan, 48322, United States

Contact Email: •••••@•••••
Henry Ford Wyandotte Hospital
RECRUITING

Wyandotte, Michigan, 48192, United States
Lahey Clinic
RECRUITING

Burlington, Massachusetts, 01805, United States
Legacy Cancer Institute Medical Oncology and Day Treatment
RECRUITING

Vancouver, Washington, 98684, United States

Contact Email: •••••@•••••
Legacy Good Samaritan Hospital and Medical Center
RECRUITING

Portland, Oregon, 97210, United States

Contact Email: •••••@•••••
Legacy Meridian Park Hospital
RECRUITING

Tualatin, Oregon, 97062, United States
Legacy Mount Hood Medical Center
RECRUITING

Gresham, Oregon, 97030, United States
Legacy Salmon Creek Hospital
RECRUITING

Vancouver, Washington, 98686, United States
London Regional Cancer Program
RECRUITING

London, Ontario, N6A 4L6, Canada
Los Angeles General Medical Center
RECRUITING

Los Angeles, California, 90033, United States

Contact Email: •••••@•••••
Marshfield Medical Center - Minocqua
RECRUITING

Minocqua, Wisconsin, 54548, United States

Contact Email: •••••@•••••
Marshfield Medical Center - Weston
RECRUITING

Weston, Wisconsin, 54476, United States

Contact Email: •••••@•••••
Marshfield Medical Center-EC Cancer Center
RECRUITING

Eau Claire, Wisconsin, 54701, United States

Contact Email: •••••@•••••
Marshfield Medical Center-Marshfield
RECRUITING

Marshfield, Wisconsin, 54449, United States

Contact Email: •••••@•••••
Marshfield Medical Center-Rice Lake
RECRUITING

Rice Lake, Wisconsin, 54868, United States

Contact Email: •••••@•••••
Marshfield Medical Center-River Region at Stevens Point
RECRUITING

Stevens Point, Wisconsin, 54482, United States

Contact Email: •••••@•••••
Medical Oncology Hematology Consultants PA
RECRUITING

Newark, Delaware, 19713, United States
Memorial Sloan Kettering Basking Ridge
RECRUITING

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Commack
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau
RECRUITING

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester
RECRUITING

Harrison, New York, 10604, United States
Mercy Hospital Saint Louis
RECRUITING

St Louis, Missouri, 63141, United States
Miami Valley Cancer Care and Infusion
RECRUITING

Greenville, Ohio, 45331, United States
Miami Valley Hospital
SUSPENDED

Dayton, Ohio, 45409, United States
Miami Valley Hospital North
RECRUITING

Dayton, Ohio, 45415, United States

Contact Email: •••••@•••••
Miami Valley Hospital South
RECRUITING

Centerville, Ohio, 45459, United States

Contact Email: •••••@•••••
Mission Hope Medical Oncology - Santa Maria
RECRUITING

Santa Maria, California, 93444, United States

Contact Email: •••••@•••••
Northwest Cancer Center - Crown Point
RECRUITING

Crown Point, Indiana, 46307, United States

Contact Email: •••••@•••••
Northwest Cancer Center - Hobart
RECRUITING

Hobart, Indiana, 46342, United States
Northwest Cancer Center - Valparaiso
RECRUITING

Valparaiso, Indiana, 46383, United States

Contact Email: •••••@•••••
Northwest Oncology LLC
RECRUITING

Dyer, Indiana, 46311, United States
Northwestern Medicine Cancer Center Delnor
RECRUITING

Geneva, Illinois, 60134, United States
Northwestern Medicine Cancer Center Kishwaukee
RECRUITING

DeKalb, Illinois, 60115, United States
Northwestern Medicine Cancer Center Warrenville
RECRUITING

Warrenville, Illinois, 60555, United States
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States

Contact Email: •••••@•••••
Ochsner Hematology Oncology North Shore - Covington (West Region)
RECRUITING

Covington, Louisiana, 70433, United States
Ochsner Medical Center Jefferson
RECRUITING

New Orleans, Louisiana, 70121, United States
Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States
Oregon Health and Science University
RECRUITING

Portland, Oregon, 97239, United States

Contact Email: •••••@•••••
Orlando Health Cancer Institute
SUSPENDED

Orlando, Florida, 32806, United States
Ottawa Hospital and Cancer Center-General Campus
RECRUITING

Ottawa, Ontario, K1H 8L6, Canada
Penn State Milton S Hershey Medical Center
RECRUITING

Hershey, Pennsylvania, 17033-0850, United States
Premier Blood and Cancer Center
RECRUITING

Dayton, Ohio, 45409, United States
Providence Newberg Medical Center
RECRUITING

Newberg, Oregon, 97132, United States

Contact Email: •••••@•••••
Providence Portland Medical Center
RECRUITING

Portland, Oregon, 97213, United States

Contact Email: •••••@•••••
Providence Saint Vincent Medical Center
RECRUITING

Portland, Oregon, 97225, United States

Contact Email: •••••@•••••
Providence Willamette Falls Medical Center
RECRUITING

Oregon City, Oregon, 97045, United States

Contact Email: •••••@•••••
Renown Regional Medical Center
RECRUITING

Reno, Nevada, 89502, United States

Contact Email: •••••@•••••
Roswell Park Cancer Institute
RECRUITING

Buffalo, New York, 14263, United States
Rush-Copley Medical Center
RECRUITING

Aurora, Illinois, 60504, United States
Saint Mary Medical Center
RECRUITING

Hobart, Indiana, 46342, United States

Contact Email: •••••@•••••
Sanford Bismarck Medical Center
RECRUITING

Bismarck, North Dakota, 58501, United States

Contact Email: •••••@•••••
Sanford Broadway Medical Center
RECRUITING

Fargo, North Dakota, 58122, United States

Contact Email: •••••@•••••
Sanford Cancer Center Oncology Clinic
RECRUITING

Sioux Falls, South Dakota, 57104, United States

Contact Email: •••••@•••••
Sanford Joe Lueken Cancer Center
RECRUITING

Bemidji, Minnesota, 56601, United States

Contact Email: •••••@•••••
Sanford Roger Maris Cancer Center
RECRUITING

Fargo, North Dakota, 58122, United States

Contact Email: •••••@•••••
Sanford USD Medical Center - Sioux Falls
RECRUITING

Sioux Falls, South Dakota, 57117-5134, United States

Contact Email: •••••@•••••
Saskatoon Cancer Centre
RECRUITING

Saskatoon, Saskatchewan, S7N 4H4, Canada
Scott and White Memorial Hospital
RECRUITING

Temple, Texas, 76508, United States
The Community Hospital
RECRUITING

Munster, Indiana, 46321, United States
The West Clinic - Wolf River
RECRUITING

Germantown, Tennessee, 38138, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center
RECRUITING

Orange, California, 92868, United States

Contact Email: •••••@•••••
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
RECRUITING

Irvine, California, 92612, United States

Contact Email: •••••@•••••
USC / Norris Comprehensive Cancer Center
RECRUITING

Los Angeles, California, 90033, United States
UT MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
University Medical Center New Orleans
RECRUITING

New Orleans, Louisiana, 70112, United States
University of Cincinnati Cancer Center-UC Medical Center
RECRUITING

Cincinnati, Ohio, 45219, United States

Contact Email: •••••@•••••
University of Cincinnati Cancer Center-West Chester
RECRUITING

West Chester, Ohio, 45069, United States

Contact Email: •••••@•••••
University of New Mexico Cancer Center
RECRUITING

Albuquerque, New Mexico, 87106, United States
University of Rochester
RECRUITING

Rochester, New York, 14642, United States
Upper Valley Medical Center
RECRUITING

Troy, Ohio, 45373, United States

Contact Email: •••••@•••••
Vanderbilt University/Ingram Cancer Center
RECRUITING

Nashville, Tennessee, 37232, United States
Virginia Mason Medical Center
RECRUITING

Seattle, Washington, 98101, United States

Contact Email: •••••@•••••
West Michigan Cancer Center
RECRUITING

Kalamazoo, Michigan, 49007, United States
Wilmot Cancer Institute at Webster
RECRUITING

Webster, New York, 14580, United States

Contact Email: •••••@•••••

More trials for these conditions

Other studies related to the condition(s) this trial covers.