New study tests if fewer radiation sessions can match standard prostate cancer treatment
NCT ID NCT06235697
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 3 trial is testing whether a shorter, more intense radiation treatment called SBRT works as well as the current standard of external radiation plus a brachytherapy boost for men with unfavorable-risk prostate cancer. About 710 participants will also receive hormone therapy. The main goal is to see if SBRT can keep cancer from progressing while being more convenient.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Radiation therapy (Stereotactic Body Radiation Therapy or SBRT) and androgen deprivation therapy (hormone therapy)
- What this could lead to
- If SBRT works as well as the standard approach, men with prostate cancer could get effective treatment in fewer sessions, making care more convenient and less invasive.
- What could go wrong
- This is a large phase 3 trial, but it's still testing whether SBRT is truly as good as the standard. There's a chance SBRT may not control the cancer as well, and side effects from radiation or hormone therapy remain possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Allegheny General Hospital
RECRUITINGPittsburgh, Pennsylvania, 15212, United States
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Billings Clinic Cancer Center
RECRUITINGBillings, Montana, 59101, United States
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Bon Secours Cancer Institute at Reynolds Crossing
RECRUITINGRichmond, Virginia, 23230, United States
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Bon Secours Saint Francis Medical Center
RECRUITINGMidlothian, Virginia, 23114, United States
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CHUM - Centre Hospitalier de l'Universite de Montreal
RECRUITINGMontreal, Quebec, H2X 3E4, Canada
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Doctor H. Bliss Murphy Cancer Centre
RECRUITINGSt. John's, Newfoundland and Labrador, A1B 3V6, Canada
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Forbes Hospital
RECRUITINGMonroeville, Pennsylvania, 15146, United States
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Jefferson Hospital
RECRUITINGJefferson Hills, Pennsylvania, 15025, United States
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Jewish General Hospital
RECRUITINGMontreal, Quebec, H3T 1E2, Canada
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Kaiser Permanente Cancer Treatment Center
RECRUITINGSouth San Francisco, California, 94080, United States
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Kaiser Permanente Downtown Commons
RECRUITINGSacramento, California, 95814, United States
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Kaiser Permanente Dublin
RECRUITINGDublin, California, 94568, United States
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Kaiser Permanente Fresno Orchard Plaza
RECRUITINGFresno, California, 93720, United States
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Kaiser Permanente Medical Center - Santa Clara
RECRUITINGSanta Clara, California, 95051, United States
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Kaiser Permanente Medical Center-Vacaville
RECRUITINGVacaville, California, 95688, United States
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Kaiser Permanente Oakland-Broadway
RECRUITINGOakland, California, 94611, United States
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Kaiser Permanente San Leandro
RECRUITINGSan Leandro, California, 94577, United States
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Kaiser Permanente- Marshall Medical Offices
RECRUITINGRedwood City, California, 94063, United States
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Kaiser Permanente-Deer Valley Medical Center
RECRUITINGAntioch, California, 94531, United States
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Kaiser Permanente-Fremont
RECRUITINGFremont, California, 94538, United States
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Kaiser Permanente-Fresno
RECRUITINGFresno, California, 93720, United States
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Kaiser Permanente-Modesto
RECRUITINGModesto, California, 95356, United States
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Kaiser Permanente-Oakland
RECRUITINGOakland, California, 94611, United States
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Kaiser Permanente-Richmond
RECRUITINGRichmond, California, 94801, United States
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Kaiser Permanente-Roseville
RECRUITINGRoseville, California, 95661, United States
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Kaiser Permanente-San Francisco
RECRUITINGSan Francisco, California, 94115, United States
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Kaiser Permanente-Santa Rosa
RECRUITINGSanta Rosa, California, 95403, United States
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Kaiser Permanente-Santa Teresa-San Jose
RECRUITINGSan Jose, California, 95119, United States
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Kaiser Permanente-South Sacramento
RECRUITINGSacramento, California, 95823, United States
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Kaiser Permanente-South San Francisco
RECRUITINGSouth San Francisco, California, 94080, United States
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Kaiser Permanente-Stockton
RECRUITINGStockton, California, 95210, United States
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Kaiser Permanente-Vallejo
RECRUITINGVallejo, California, 94589, United States
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Kaiser Permanente-Walnut Creek
RECRUITINGWalnut Creek, California, 94596, United States
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Kaiser San Rafael-Gallinas
RECRUITINGSan Rafael, California, 94903, United States
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Kingston Health Sciences Centre
RECRUITINGKingston, Ontario, K7L 2V7, Canada
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Lakeridge Health Oshawa
RECRUITINGOshawa, Ontario, L1G 2B9, Canada
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Lenox Hill Hospital
RECRUITINGNew York, New York, 10075, United States
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London Regional Cancer Program
RECRUITINGLondon, Ontario, N6A 4L6, Canada
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Manhattan Eye Ear and Throat Hospital
RECRUITINGNew York, New York, 10065, United States
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Memorial Hospital East
RECRUITINGShiloh, Illinois, 62269, United States
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Northwell Health/Center for Advanced Medicine
RECRUITINGLake Success, New York, 11042, United States
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Odette Cancer Centre- Sunnybrook Health Sciences Centre
RECRUITINGToronto, Ontario, M4N 3M5, Canada
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Rohnert Park Cancer Center
RECRUITINGRohnert Park, California, 94928, United States
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Royal Victoria Regional Health Centre
RECRUITINGBarrie, Ontario, L4M 6M2, Canada
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Saint Vincent Hospital
RECRUITINGErie, Pennsylvania, 16544, United States
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Siteman Cancer Center at Christian Hospital
RECRUITINGSt Louis, Missouri, 63136, United States
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Siteman Cancer Center at Saint Peters Hospital
RECRUITINGCity of Saint Peters, Missouri, 63376, United States
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Siteman Cancer Center at West County Hospital
RECRUITINGCreve Coeur, Missouri, 63141, United States
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Siteman Cancer Center-South County
RECRUITINGSt Louis, Missouri, 63129, United States
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The Permanente Medical Group-Roseville Radiation Oncology
RECRUITINGRoseville, California, 95678, United States
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Trillium Health Partners - Credit Valley Hospital
RECRUITINGMississauga, Ontario, L5M 2N1, Canada
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University Health Network-Princess Margaret Hospital
RECRUITINGToronto, Ontario, M5G 2M9, Canada
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VCU Massey Comprehensive Cancer Center
RECRUITINGRichmond, Virginia, 23298, United States
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Washington University School of Medicine
RECRUITINGSt Louis, Missouri, 63110, United States
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Waterloo Regional Health Network
RECRUITINGKitchener, Ontario, N2G 1G3, Canada
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West Penn Hospital
RECRUITINGPittsburgh, Pennsylvania, 15224, United States
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Wexford Health and Wellness Pavilion
RECRUITINGWexford, Pennsylvania, 15090, United States
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More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A surgical tweak may speed bladder control recovery after prostate removal
- Smarter prostate cancer screening: a blood test that may cut unnecessary biopsies
- Glow-in-the-dark dye may help surgeons spot hidden prostate cancer cells
- Blood DNA fragments and MRI join forces to spot hidden prostate cancer
- Can an AI agent match expert urologists? a major test begins
- Pumping iron to fight cancer's hidden immune toll