Can taking drug breaks work as well as continuous treatment for melanoma?

NCT ID NCT02821013

Recruiting now Disease control Sponsor: Canadian Cancer Trials Group Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether taking a standard immunotherapy drug (PD-1 inhibitor) on an intermittent schedule works as well as taking it continuously for people with advanced melanoma that cannot be removed by surgery. About 614 participants will be randomly assigned to one of the two schedules. The main goal is to see if overall survival is similar between the groups, while also checking side effects and quality of life.

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Conditions

The condition(s) this trial relates to.

melanoma metastatic melanoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

UNRESECTABLE/METASTATIC MELANOMA

Contacts and locations

Locations

Alfred Hospital
RECRUITING

Melbourne, Victoria, 3004, Australia
Allan Blair Cancer Centre
RECRUITING

Regina, Saskatchewan, S4T 7T1, Canada
BCCA - Surrey
RECRUITING

Surrey, British Columbia, V3V 1Z2, Canada
BCCA - Vancouver
RECRUITING

Vancouver, British Columbia, V5Z 4E6, Canada
BCCA - Victoria
RECRUITING

Victoria, British Columbia, V8R 6V5, Canada
Cairns Hospital
RECRUITING

Cairns, Queensland, 4870, Australia
Calvary Mater Newcastle Hospital
RECRUITING

Waratah, New South Wales, 2298, Australia
Coffs Habour Health Campus - NCCI
RECRUITING

Coffs Harbour, New South Wales, 2450, Australia
Cross Cancer Institute
RECRUITING

Edmonton, Alberta, T6G 1Z2, Canada
Gold Coast University Hospital
RECRUITING

Southport, Queensland, 4215, Australia
Health Sciences North
RECRUITING

Greater Sudbury, Ontario, P3E 5J1, Canada
Horizon Health Network
RECRUITING

Fredericton, New Brunswick, E3B 5N5, Canada
Juravinski Cancer Centre at Hamilton Health Sciences
RECRUITING

Hamilton, Ontario, L8V 5C2, Canada
Kingston Health Sciences Centre
RECRUITING

Kingston, Ontario, K7L 2V7, Canada
Lakeridge Health Oshawa
RECRUITING

Oshawa, Ontario, L1G 2B9, Canada
London Health Sciences Centre Research Inc.
RECRUITING

London, Ontario, N6A 5W9, Canada
Mildura Base Public Hospital
RECRUITING

Victoria, Mildura, 3500, Australia
Monash Medical Centre
RECRUITING

Clayton, Victoria, 3168, Australia
Odette Cancer Centre
RECRUITING

Toronto, Ontario, M4N 3M5, Canada
Ottawa Hospital Research Institute
RECRUITING

Ottawa, Ontario, K1H 8L6, Canada
Royal Brisbane and Womens Hospital
RECRUITING

Herston, 4029, Australia
Royal Victoria Regional Health Centre
RECRUITING

Barrie, Ontario, L4M 6M2, Canada
Saskatoon Cancer Centre
RECRUITING

Saskatoon, Saskatchewan, S7N 4H4, Canada
Sunshine Coast University Hospital
RECRUITING

Birtinya, Queensland, 4575, Australia
The Queen Elizabeth Hospital
RECRUITING

Woodville, South A., 5011, Australia
The Research Institute of the McGill University
RECRUITING

Montreal, Quebec, H4A 3J1, Canada
Trillium Health Partners - Credit Valley Hospital
RECRUITING

Mississauga, Ontario, L5M 2N1, Canada
University Health Network
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
Waterloo Regional Health Network (WRHN)
RECRUITING

Kitchener, Ontario, N2G 1G3, Canada
Westmead Hospital
RECRUITING

Westmead, New South Wales, 2145, Australia